The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory

Brain oedema is thought to form and to clear through the use of water-protein channels, aquaporin-4 (AQP4), which are found in the astrocyte endfeet. The model developed here is used to study the function of AQP4 in the formation and elimination of oedema fluid in ischaemia-reperfusion injury. The c...

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Main Authors:	Mohd Jamil Mohamed, Mokhtarudin, Payne, Stephen J.
Format:	Article
Language:	English
Published:	Wiley 2017
Subjects:	TJ Mechanical engineering and machinery
Online Access:	http://umpir.ump.edu.my/id/eprint/17822/ http://umpir.ump.edu.my/id/eprint/17822/ http://umpir.ump.edu.my/id/eprint/17822/ http://umpir.ump.edu.my/id/eprint/17822/1/fkm-2017-Mokhtarudin-The%20study%20of%20the%20function%20of%20AQP41.pdf

id	ump-17822
recordtype	eprints
spelling	ump-178222018-08-29T03:15:11Z http://umpir.ump.edu.my/id/eprint/17822/ The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory Mohd Jamil Mohamed, Mokhtarudin Payne, Stephen J. TJ Mechanical engineering and machinery Brain oedema is thought to form and to clear through the use of water-protein channels, aquaporin-4 (AQP4), which are found in the astrocyte endfeet. The model developed here is used to study the function of AQP4 in the formation and elimination of oedema fluid in ischaemia-reperfusion injury. The cerebral space is assumed to be made of four fluid compartments: astrocyte, neuron, ECS and blood microvessels, and a solid matrix for the tissue, and this is modelled using multiple-network poroelastic theory. AQP4 allows the movement of water between astrocyte and the ECS and the microvessels. It is found that the presence of AQP4 may help in reducing vasogenic oedema shown by a decrease in brain tissue extracellular pressure. However, the astrocyte pressure will increase to compensate for this decrease, which may lead to cytotoxic oedema. In addition, the swelling will also depend on the ionic concentrations in the astrocyte and extracellular space, which may change after ischaemic stroke. Understanding the role of AQP4 in oedema may thus help the development of a treatment plan in reducing brain swelling after ischaemia-reperfusion. Wiley 2017 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/17822/1/fkm-2017-Mokhtarudin-The%20study%20of%20the%20function%20of%20AQP41.pdf Mohd Jamil Mohamed, Mokhtarudin and Payne, Stephen J. (2017) The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory. International Journal for Numerical Methods In Biomedical Engineering, 33 (1). pp. 1-14. ISSN 2040-7939 (print); 2040-7947 (online) https://doi.org/10.1002/cnm.2784 DOI: 10.1002/cnm.2784
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TJ Mechanical engineering and machinery
spellingShingle	TJ Mechanical engineering and machinery Mohd Jamil Mohamed, Mokhtarudin Payne, Stephen J. The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory
description	Brain oedema is thought to form and to clear through the use of water-protein channels, aquaporin-4 (AQP4), which are found in the astrocyte endfeet. The model developed here is used to study the function of AQP4 in the formation and elimination of oedema fluid in ischaemia-reperfusion injury. The cerebral space is assumed to be made of four fluid compartments: astrocyte, neuron, ECS and blood microvessels, and a solid matrix for the tissue, and this is modelled using multiple-network poroelastic theory. AQP4 allows the movement of water between astrocyte and the ECS and the microvessels. It is found that the presence of AQP4 may help in reducing vasogenic oedema shown by a decrease in brain tissue extracellular pressure. However, the astrocyte pressure will increase to compensate for this decrease, which may lead to cytotoxic oedema. In addition, the swelling will also depend on the ionic concentrations in the astrocyte and extracellular space, which may change after ischaemic stroke. Understanding the role of AQP4 in oedema may thus help the development of a treatment plan in reducing brain swelling after ischaemia-reperfusion.
format	Article
author	Mohd Jamil Mohamed, Mokhtarudin Payne, Stephen J.
author_facet	Mohd Jamil Mohamed, Mokhtarudin Payne, Stephen J.
author_sort	Mohd Jamil Mohamed, Mokhtarudin
title	The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory
title_short	The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory
title_full	The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory
title_fullStr	The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory
title_full_unstemmed	The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory
title_sort	study of the function of aqp4 in cerebral ischaemia-reperfusion injury using poroelastic theory
publisher	Wiley
publishDate	2017
url	http://umpir.ump.edu.my/id/eprint/17822/ http://umpir.ump.edu.my/id/eprint/17822/ http://umpir.ump.edu.my/id/eprint/17822/ http://umpir.ump.edu.my/id/eprint/17822/1/fkm-2017-Mokhtarudin-The%20study%20of%20the%20function%20of%20AQP41.pdf
first_indexed	2023-09-18T22:24:51Z
last_indexed	2023-09-18T22:24:51Z
_version_	1777415897678348288

The Study of the Function of AQP4 in Cerebral Ischaemia-Reperfusion Injury using Poroelastic Theory

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