Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules

Peroxisome proliferator-activated receptor gamma (PPARγ), a type II nuclear receptor present in adipose tissue, colon and macrophages. It reduces the hyperglycemia associated metabolic syndromes. Particularly, type II diabetes-related cardiovascular system risk in human beings. The fatty acid storag...

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Main Authors:	Prabhu, S., Vijayakumar, S., Manogar, P., Gaanty Pragas, Maniam, Natanamurugaraj, Govindan
Format:	Article
Language:	English
Published:	Elsevier Ltd 2017
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/17914/ http://umpir.ump.edu.my/id/eprint/17914/ http://umpir.ump.edu.my/id/eprint/17914/ http://umpir.ump.edu.my/id/eprint/17914/1/Homology%20Modeling%20and%20Molecular%20Docking%20Studies%20on%20Type%20II-1.pdf

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recordtype	eprints
spelling	ump-179142018-07-13T08:42:23Z http://umpir.ump.edu.my/id/eprint/17914/ Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules Prabhu, S. Vijayakumar, S. Manogar, P. Gaanty Pragas, Maniam Natanamurugaraj, Govindan TP Chemical technology Peroxisome proliferator-activated receptor gamma (PPARγ), a type II nuclear receptor present in adipose tissue, colon and macrophages. It reduces the hyperglycemia associated metabolic syndromes. Particularly, type II diabetes-related cardiovascular system risk in human beings. The fatty acid storage and glucose metabolism are regulated by PPARγ activation in human body. According to recent reports commercially available PPARγ activating drugs have been causing severe side effects. At the same time, natural products have been proved to be a promising area of drug discovery. Recently, many studies have been attempted to screen and identify a potential drug candidate to activate PPARγ. Hence, in this study we have selected some of the bio-active molecules from traditional medicinal plants. Molecular docking studies have been carried out against the target, PPARγ. We Results suggested that Punigluconin has a efficient docking score and it is found to have good binding affinities than other ligands. Hence, we concluded that Punigluconin is a better drug candidate for activation of PPARγ gene expression. Further studies are necessary to confirm their efficacy and possibly it can develop as a potential drug in future. Elsevier Ltd 2017 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/17914/1/Homology%20Modeling%20and%20Molecular%20Docking%20Studies%20on%20Type%20II-1.pdf Prabhu, S. and Vijayakumar, S. and Manogar, P. and Gaanty Pragas, Maniam and Natanamurugaraj, Govindan (2017) Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules. Biomedicine & Pharmacotherapy, 92. pp. 528-535. ISSN 0753-3322 https://doi.org/10.1016/j.biopha.2017.05.077 doi: 10.1016/j.biopha.2017.05.077
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Prabhu, S. Vijayakumar, S. Manogar, P. Gaanty Pragas, Maniam Natanamurugaraj, Govindan Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules
description	Peroxisome proliferator-activated receptor gamma (PPARγ), a type II nuclear receptor present in adipose tissue, colon and macrophages. It reduces the hyperglycemia associated metabolic syndromes. Particularly, type II diabetes-related cardiovascular system risk in human beings. The fatty acid storage and glucose metabolism are regulated by PPARγ activation in human body. According to recent reports commercially available PPARγ activating drugs have been causing severe side effects. At the same time, natural products have been proved to be a promising area of drug discovery. Recently, many studies have been attempted to screen and identify a potential drug candidate to activate PPARγ. Hence, in this study we have selected some of the bio-active molecules from traditional medicinal plants. Molecular docking studies have been carried out against the target, PPARγ. We Results suggested that Punigluconin has a efficient docking score and it is found to have good binding affinities than other ligands. Hence, we concluded that Punigluconin is a better drug candidate for activation of PPARγ gene expression. Further studies are necessary to confirm their efficacy and possibly it can develop as a potential drug in future.
format	Article
author	Prabhu, S. Vijayakumar, S. Manogar, P. Gaanty Pragas, Maniam Natanamurugaraj, Govindan
author_facet	Prabhu, S. Vijayakumar, S. Manogar, P. Gaanty Pragas, Maniam Natanamurugaraj, Govindan
author_sort	Prabhu, S.
title	Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules
title_short	Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules
title_full	Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules
title_fullStr	Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules
title_full_unstemmed	Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules
title_sort	homology modeling and molecular docking studies on type ii diabetes complications reduced pparγ receptor with various ligand molecules
publisher	Elsevier Ltd
publishDate	2017
url	http://umpir.ump.edu.my/id/eprint/17914/ http://umpir.ump.edu.my/id/eprint/17914/ http://umpir.ump.edu.my/id/eprint/17914/ http://umpir.ump.edu.my/id/eprint/17914/1/Homology%20Modeling%20and%20Molecular%20Docking%20Studies%20on%20Type%20II-1.pdf
first_indexed	2023-09-18T22:25:03Z
last_indexed	2023-09-18T22:25:03Z
_version_	1777415910095585280

Homology Modeling and Molecular Docking Studies on Type II Diabetes Complications Reduced PPARγ Receptor with Various Ligand Molecules

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