Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate

This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced wer...

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Main Authors:	Siti Kholijah, Abdul Mudalip, Fatmawati, Adam, Jamal, Parveen, Mohd Rushdi, Abu Bakar, Norliyana, Amran, Siti Zubaidah, Sulaiman, Rohaida, Che Man, Zatul Iffah, Mohd Arshad, Shalyda, Md Shaarani
Format:	Conference or Workshop Item
Language:	English
Published:	IOP Publishing 2017
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/18006/ http://umpir.ump.edu.my/id/eprint/18006/ http://umpir.ump.edu.my/id/eprint/18006/1/Abdul_Mudalip_2017_IOP_Conf._Ser.__Mater._Sci._Eng._205_012025.pdf

id	ump-18006
recordtype	eprints
spelling	ump-180062017-08-16T03:01:25Z http://umpir.ump.edu.my/id/eprint/18006/ Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate Siti Kholijah, Abdul Mudalip Fatmawati, Adam Jamal, Parveen Mohd Rushdi, Abu Bakar Norliyana, Amran Siti Zubaidah, Sulaiman Rohaida, Che Man Zatul Iffah, Mohd Arshad Shalyda, Md Shaarani TP Chemical technology This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced were analysed using optical microscopy and Fourier transform infrared spectroscopy (FTIR). It was found that the crystals produced at different cooling rates were needle-like and exhibit polymorphic form type I. However, the aspect ratio and crystal size distributions were varied with the increased of cooling rate. A high crystals aspect ratio and narrower CSD (100−900 μm) was obtained at cooling rate of 0.5 °C/min. Thus, can be suggested as the most suitable cooling rate for crystallization of mefenamic acid in ethyl acetate. IOP Publishing 2017 Conference or Workshop Item PeerReviewed application/pdf en cc_by http://umpir.ump.edu.my/id/eprint/18006/1/Abdul_Mudalip_2017_IOP_Conf._Ser.__Mater._Sci._Eng._205_012025.pdf Siti Kholijah, Abdul Mudalip and Fatmawati, Adam and Jamal, Parveen and Mohd Rushdi, Abu Bakar and Norliyana, Amran and Siti Zubaidah, Sulaiman and Rohaida, Che Man and Zatul Iffah, Mohd Arshad and Shalyda, Md Shaarani (2017) Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate. In: IOP Conference Series: Materials Science and Engineering, The 2nd International Conference on Materials Engineering and Nanotechnology, 12-14 May 2017 , Kuala Lumpur, Malaysia. pp. 1-5., 205 (012025). ISSN 1757-8981 (Print), 1757-899X (Online) https://doi.org/10.1088/1757-899X/205/1/012025
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Siti Kholijah, Abdul Mudalip Fatmawati, Adam Jamal, Parveen Mohd Rushdi, Abu Bakar Norliyana, Amran Siti Zubaidah, Sulaiman Rohaida, Che Man Zatul Iffah, Mohd Arshad Shalyda, Md Shaarani Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate
description	This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced were analysed using optical microscopy and Fourier transform infrared spectroscopy (FTIR). It was found that the crystals produced at different cooling rates were needle-like and exhibit polymorphic form type I. However, the aspect ratio and crystal size distributions were varied with the increased of cooling rate. A high crystals aspect ratio and narrower CSD (100−900 μm) was obtained at cooling rate of 0.5 °C/min. Thus, can be suggested as the most suitable cooling rate for crystallization of mefenamic acid in ethyl acetate.
format	Conference or Workshop Item
author	Siti Kholijah, Abdul Mudalip Fatmawati, Adam Jamal, Parveen Mohd Rushdi, Abu Bakar Norliyana, Amran Siti Zubaidah, Sulaiman Rohaida, Che Man Zatul Iffah, Mohd Arshad Shalyda, Md Shaarani
author_facet	Siti Kholijah, Abdul Mudalip Fatmawati, Adam Jamal, Parveen Mohd Rushdi, Abu Bakar Norliyana, Amran Siti Zubaidah, Sulaiman Rohaida, Che Man Zatul Iffah, Mohd Arshad Shalyda, Md Shaarani
author_sort	Siti Kholijah, Abdul Mudalip
title	Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate
title_short	Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate
title_full	Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate
title_fullStr	Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate
title_full_unstemmed	Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate
title_sort	effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate
publisher	IOP Publishing
publishDate	2017
url	http://umpir.ump.edu.my/id/eprint/18006/ http://umpir.ump.edu.my/id/eprint/18006/ http://umpir.ump.edu.my/id/eprint/18006/1/Abdul_Mudalip_2017_IOP_Conf._Ser.__Mater._Sci._Eng._205_012025.pdf
first_indexed	2023-09-18T22:25:13Z
last_indexed	2023-09-18T22:25:13Z
_version_	1777415921408671744

Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate

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