The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells

Curcumin is one of the promising natural products extracted from the rhizomes of curcuma longa and has been extensively investigated by researchers to explore its potential as a chemopreventive and therapeutic agent against several chronic diseases. To further enhance the cytotoxic potential of curc...

Full description

Bibliographic Details
Main Authors:	Nursyamirah, Abd Razak, Akhtar, Muhammad Nadeem, Nadiah, Abu, Wan, Yong Ho, Sheau, Wei Tan, Seema, Zareen, Saiful Nizam, Tajuddin, Kamariah, Long, Noorjahan Banu, Alitheen, Swee, Keong Yeap
Format:	Article
Language:	English
Published:	Royal Society of Chemistry 2017
Subjects:	Q Science (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/18564/ http://umpir.ump.edu.my/id/eprint/18564/ http://umpir.ump.edu.my/id/eprint/18564/ http://umpir.ump.edu.my/id/eprint/18564/1/The%20In%20Vivo%20Anti-Tumor%20Effect%20of%20Curcumin%20Derivative%20%282E%2C6E%29-2%2C6-bis%284-hydroxy-3-methoxybenzylidene%29%20Cyclohexanone%20%28BHMC%29%20on%204T1%20Breast%20Cancer%20Cells.pdf

id	ump-18564
recordtype	eprints
spelling	ump-185642018-03-07T00:10:04Z http://umpir.ump.edu.my/id/eprint/18564/ The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells Nursyamirah, Abd Razak Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Sheau, Wei Tan Seema, Zareen Saiful Nizam, Tajuddin Kamariah, Long Noorjahan Banu, Alitheen Swee, Keong Yeap Q Science (General) Curcumin is one of the promising natural products extracted from the rhizomes of curcuma longa and has been extensively investigated by researchers to explore its potential as a chemopreventive and therapeutic agent against several chronic diseases. To further enhance the cytotoxic potential of curcumin, its derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) has been synthesized and investigated, and its antitumor effect on tested on 4T1 challenged mice. BHMC was recorded with in vitro cytotoxicity on murine 4T1 breast cancer cells with IC50 value 13.66 mM, which was 2 times lower than curcumin after 72 hours of treatment. An in vivo study indicated that BHMC possessed antitumor effect on the 4T1 cells of the challenged mice by induction of apoptosis, antiproliferation, antiinflammation and antimetastasis. This effect is better compared to curcumin treatment at the same evaluated concentration. Thus, BHMC is a potential antitumor agent against breast cancer. Royal Society of Chemistry 2017 Article PeerReviewed application/pdf en cc_by http://umpir.ump.edu.my/id/eprint/18564/1/The%20In%20Vivo%20Anti-Tumor%20Effect%20of%20Curcumin%20Derivative%20%282E%2C6E%29-2%2C6-bis%284-hydroxy-3-methoxybenzylidene%29%20Cyclohexanone%20%28BHMC%29%20on%204T1%20Breast%20Cancer%20Cells.pdf Nursyamirah, Abd Razak and Akhtar, Muhammad Nadeem and Nadiah, Abu and Wan, Yong Ho and Sheau, Wei Tan and Seema, Zareen and Saiful Nizam, Tajuddin and Kamariah, Long and Noorjahan Banu, Alitheen and Swee, Keong Yeap (2017) The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells. RSC Advances, 7 (57). pp. 36185-36192. ISSN 2046-2069 http://dx.doi.org/10.1039/C7RA06580A doi: 10.1039/C7RA06580A
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Nursyamirah, Abd Razak Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Sheau, Wei Tan Seema, Zareen Saiful Nizam, Tajuddin Kamariah, Long Noorjahan Banu, Alitheen Swee, Keong Yeap The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells
description	Curcumin is one of the promising natural products extracted from the rhizomes of curcuma longa and has been extensively investigated by researchers to explore its potential as a chemopreventive and therapeutic agent against several chronic diseases. To further enhance the cytotoxic potential of curcumin, its derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) has been synthesized and investigated, and its antitumor effect on tested on 4T1 challenged mice. BHMC was recorded with in vitro cytotoxicity on murine 4T1 breast cancer cells with IC50 value 13.66 mM, which was 2 times lower than curcumin after 72 hours of treatment. An in vivo study indicated that BHMC possessed antitumor effect on the 4T1 cells of the challenged mice by induction of apoptosis, antiproliferation, antiinflammation and antimetastasis. This effect is better compared to curcumin treatment at the same evaluated concentration. Thus, BHMC is a potential antitumor agent against breast cancer.
format	Article
author	Nursyamirah, Abd Razak Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Sheau, Wei Tan Seema, Zareen Saiful Nizam, Tajuddin Kamariah, Long Noorjahan Banu, Alitheen Swee, Keong Yeap
author_facet	Nursyamirah, Abd Razak Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Sheau, Wei Tan Seema, Zareen Saiful Nizam, Tajuddin Kamariah, Long Noorjahan Banu, Alitheen Swee, Keong Yeap
author_sort	Nursyamirah, Abd Razak
title	The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells
title_short	The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells
title_full	The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells
title_fullStr	The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells
title_full_unstemmed	The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells
title_sort	in vivo anti-tumor effect of curcumin derivative (2e,6e)-2,6-bis(4-hydroxy-3-methoxybenzylidene) cyclohexanone (bhmc) on 4t1 breast cancer cells
publisher	Royal Society of Chemistry
publishDate	2017
url	http://umpir.ump.edu.my/id/eprint/18564/ http://umpir.ump.edu.my/id/eprint/18564/ http://umpir.ump.edu.my/id/eprint/18564/ http://umpir.ump.edu.my/id/eprint/18564/1/The%20In%20Vivo%20Anti-Tumor%20Effect%20of%20Curcumin%20Derivative%20%282E%2C6E%29-2%2C6-bis%284-hydroxy-3-methoxybenzylidene%29%20Cyclohexanone%20%28BHMC%29%20on%204T1%20Breast%20Cancer%20Cells.pdf
first_indexed	2023-09-18T22:26:22Z
last_indexed	2023-09-18T22:26:22Z
_version_	1777415993450037248

The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells

Similar Items