Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits

Melting temperature (Tmelt) and enthalpy of fussion (ΔHf) are important parameters to determine the quality and the thermal stability of active pharmaceutical ingredient (API) crystals. In this study, different habit of ascorbic acid was prepared by using different polar solvents namely water, metha...

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Main Authors:	Shajaratul Jahriah, Hassan, Fatmawati, Adam, M. R., Abu Bakar
Format:	Article
Language:	English
Published:	Universiti Malaysia Pahang 2018
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/21402/ http://umpir.ump.edu.my/id/eprint/21402/ http://umpir.ump.edu.my/id/eprint/21402/ http://umpir.ump.edu.my/id/eprint/21402/1/Thermal%20Characteristic%20Evaluation%20of%20Different-fkksa-2018.pdf

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recordtype	eprints
spelling	ump-214022019-05-02T08:07:08Z http://umpir.ump.edu.my/id/eprint/21402/ Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits Shajaratul Jahriah, Hassan Fatmawati, Adam M. R., Abu Bakar TP Chemical technology Melting temperature (Tmelt) and enthalpy of fussion (ΔHf) are important parameters to determine the quality and the thermal stability of active pharmaceutical ingredient (API) crystals. In this study, different habit of ascorbic acid was prepared by using different polar solvents namely water, methanol, ethanol and 2-propanol. Ascorbic acid crystal was then been physically and thermally characterized by using microscopic analysis, thermo gravimetric analysis (TGA) and differential scanning calometry analysis (DSC). This provides an insight into the formation of crystal habit across four different polar protic solvents. The ascorbic acid is found to grow as a cubic or prism crystal when grown in water that provides high hydrogen bond between solvent and solute. As the polarity of the solvents decrease, the hydrogen bond weaken and the width of the crystal become narrower, forming almost a needle like crystal. The thermal stability of ascorbic acid crystal is found to be the most stable when ascorbic acid is crystallized from water (prism) and the weakest from 2-Propanol (needle) due to the molecule arrangement in crystal lattice in which resulted from decreasing intermolecular forces in the liquid phase. Universiti Malaysia Pahang 2018 Article PeerReviewed text en http://umpir.ump.edu.my/id/eprint/21402/1/Thermal%20Characteristic%20Evaluation%20of%20Different-fkksa-2018.pdf Shajaratul Jahriah, Hassan and Fatmawati, Adam and M. R., Abu Bakar (2018) Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits. Journal of Chemical Engineering and Industrial Biotechnology (JCEIB), 3. pp. 50-59. ISSN 0126-8139 http://jceib.ump.edu.my/index.php/en/volume-3-docman/74-thermal-characteristic-evaluation-of-different-ascorbic-acid-crystal-habits/file DOI: https:/ /doi.org/10.15282/JCEIB-V3-08.28/3/2018/3.3
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Shajaratul Jahriah, Hassan Fatmawati, Adam M. R., Abu Bakar Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits
description	Melting temperature (Tmelt) and enthalpy of fussion (ΔHf) are important parameters to determine the quality and the thermal stability of active pharmaceutical ingredient (API) crystals. In this study, different habit of ascorbic acid was prepared by using different polar solvents namely water, methanol, ethanol and 2-propanol. Ascorbic acid crystal was then been physically and thermally characterized by using microscopic analysis, thermo gravimetric analysis (TGA) and differential scanning calometry analysis (DSC). This provides an insight into the formation of crystal habit across four different polar protic solvents. The ascorbic acid is found to grow as a cubic or prism crystal when grown in water that provides high hydrogen bond between solvent and solute. As the polarity of the solvents decrease, the hydrogen bond weaken and the width of the crystal become narrower, forming almost a needle like crystal. The thermal stability of ascorbic acid crystal is found to be the most stable when ascorbic acid is crystallized from water (prism) and the weakest from 2-Propanol (needle) due to the molecule arrangement in crystal lattice in which resulted from decreasing intermolecular forces in the liquid phase.
format	Article
author	Shajaratul Jahriah, Hassan Fatmawati, Adam M. R., Abu Bakar
author_facet	Shajaratul Jahriah, Hassan Fatmawati, Adam M. R., Abu Bakar
author_sort	Shajaratul Jahriah, Hassan
title	Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits
title_short	Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits
title_full	Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits
title_fullStr	Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits
title_full_unstemmed	Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits
title_sort	thermal characteristic evaluation of different ascorbic acid crystal habits
publisher	Universiti Malaysia Pahang
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/21402/ http://umpir.ump.edu.my/id/eprint/21402/ http://umpir.ump.edu.my/id/eprint/21402/ http://umpir.ump.edu.my/id/eprint/21402/1/Thermal%20Characteristic%20Evaluation%20of%20Different-fkksa-2018.pdf
first_indexed	2023-09-18T22:31:23Z
last_indexed	2023-09-18T22:31:23Z
_version_	1777416308613185536

Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits

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