Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors

Pain is one of the most common cause for hospital visits. It plays an important role in inflammation and serves as a warning sign to avoid further injury. Analgesics are used to manage pain and provide comfort to patients. However, prolonged usage of pain treatments like opioids and NSAIDs are accom...

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Main Authors:	Chung, Pui Ping, Tengku Azam Shah, Tengku Mohamad, Akhtar, Muhammad Nadeem, Enoch Kumar, Perimal, Ahmad, Akira, Daud Ahmad, Israf Ali, Mohd Roslan, Sulaiman
Format:	Article
Language:	English
Published:	MDPI - Open Access Publishing 2018
Subjects:	QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/22118/ http://umpir.ump.edu.my/id/eprint/22118/ http://umpir.ump.edu.my/id/eprint/22118/ http://umpir.ump.edu.my/id/eprint/22118/1/Antinociceptive%20Effects%20of%20Cardamonin%20in%20Mice.pdf

id	ump-22118
recordtype	eprints
spelling	ump-221182018-09-18T02:54:49Z http://umpir.ump.edu.my/id/eprint/22118/ Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors Chung, Pui Ping Tengku Azam Shah, Tengku Mohamad Akhtar, Muhammad Nadeem Enoch Kumar, Perimal Ahmad, Akira Daud Ahmad, Israf Ali Mohd Roslan, Sulaiman QD Chemistry Pain is one of the most common cause for hospital visits. It plays an important role in inflammation and serves as a warning sign to avoid further injury. Analgesics are used to manage pain and provide comfort to patients. However, prolonged usage of pain treatments like opioids and NSAIDs are accompanied with undesirable side effects. Therefore, research to identify novel compounds that produce analgesia with lesser side effects are necessary. The present study investigated the antinociceptive potentials of a natural compound, cardamonin, isolated from Boesenbergia rotunda (L) Mansf. using chemical and thermal models of nociception. Our findings showed that intraperitoneal and oral administration of cardamonin (0.3, 1, 3, and 10 mg/kg) produced significant and dose-dependent inhibition of pain in abdominal writhing responses induced by acetic acid. The present study also demonstrated that cardamonin produced significant analgesia in formalin-, capsaicin-, and glutamate-induced paw licking tests. In the thermal-induced nociception model, cardamonin exhibited significant increase in response latency time of animals subjected to hot-plate thermal stimuli. The rota-rod assessment confirmed that the antinociceptive activities elicited by cardamonin was not related to muscle relaxant or sedative effects of the compound. In conclusion, the present findings showed that cardamonin exerted significant peripheral and central antinociception through chemical- and thermal-induced nociception in mice through the involvement of TRPV1, glutamate, and opioid receptors. MDPI - Open Access Publishing 2018 Article PeerReviewed pdf en cc_by http://umpir.ump.edu.my/id/eprint/22118/1/Antinociceptive%20Effects%20of%20Cardamonin%20in%20Mice.pdf Chung, Pui Ping and Tengku Azam Shah, Tengku Mohamad and Akhtar, Muhammad Nadeem and Enoch Kumar, Perimal and Ahmad, Akira and Daud Ahmad, Israf Ali and Mohd Roslan, Sulaiman (2018) Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors. Molecules, 23 (9). pp. 1-14. ISSN 1420-3049 (print); 1420-3049 (online) http://dx.doi.org/10.3390/molecules23092237 doi:10.3390/molecules23092237
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Chung, Pui Ping Tengku Azam Shah, Tengku Mohamad Akhtar, Muhammad Nadeem Enoch Kumar, Perimal Ahmad, Akira Daud Ahmad, Israf Ali Mohd Roslan, Sulaiman Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors
description	Pain is one of the most common cause for hospital visits. It plays an important role in inflammation and serves as a warning sign to avoid further injury. Analgesics are used to manage pain and provide comfort to patients. However, prolonged usage of pain treatments like opioids and NSAIDs are accompanied with undesirable side effects. Therefore, research to identify novel compounds that produce analgesia with lesser side effects are necessary. The present study investigated the antinociceptive potentials of a natural compound, cardamonin, isolated from Boesenbergia rotunda (L) Mansf. using chemical and thermal models of nociception. Our findings showed that intraperitoneal and oral administration of cardamonin (0.3, 1, 3, and 10 mg/kg) produced significant and dose-dependent inhibition of pain in abdominal writhing responses induced by acetic acid. The present study also demonstrated that cardamonin produced significant analgesia in formalin-, capsaicin-, and glutamate-induced paw licking tests. In the thermal-induced nociception model, cardamonin exhibited significant increase in response latency time of animals subjected to hot-plate thermal stimuli. The rota-rod assessment confirmed that the antinociceptive activities elicited by cardamonin was not related to muscle relaxant or sedative effects of the compound. In conclusion, the present findings showed that cardamonin exerted significant peripheral and central antinociception through chemical- and thermal-induced nociception in mice through the involvement of TRPV1, glutamate, and opioid receptors.
format	Article
author	Chung, Pui Ping Tengku Azam Shah, Tengku Mohamad Akhtar, Muhammad Nadeem Enoch Kumar, Perimal Ahmad, Akira Daud Ahmad, Israf Ali Mohd Roslan, Sulaiman
author_facet	Chung, Pui Ping Tengku Azam Shah, Tengku Mohamad Akhtar, Muhammad Nadeem Enoch Kumar, Perimal Ahmad, Akira Daud Ahmad, Israf Ali Mohd Roslan, Sulaiman
author_sort	Chung, Pui Ping
title	Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors
title_short	Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors
title_full	Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors
title_fullStr	Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors
title_full_unstemmed	Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors
title_sort	antinociceptive effects of cardamonin in mice: possible involvement of trpv1, glutamate, and opioid receptors
publisher	MDPI - Open Access Publishing
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/22118/ http://umpir.ump.edu.my/id/eprint/22118/ http://umpir.ump.edu.my/id/eprint/22118/ http://umpir.ump.edu.my/id/eprint/22118/1/Antinociceptive%20Effects%20of%20Cardamonin%20in%20Mice.pdf
first_indexed	2023-09-18T22:32:45Z
last_indexed	2023-09-18T22:32:45Z
_version_	1777416394977050624

Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors

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