Fabrication of bone scaffolds from Anadara Granosa shell waste

Bone defect and irregularities may cause by traumatic injuries or pathological condition such as osteoporosis and bone cancer [1-3]. In today’s medical practices, traditional treatment methods like autograft and allograft are still being used to treat the bone defect. However, these methods have som...

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Main Authors:	Siti Hajar, Saharudin, Jun Haslinda, Shariffuddin, Noor Ida Amalina, Ahamad Nordin
Format:	Conference or Workshop Item
Language:	English English
Published:	2018
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/22204/ http://umpir.ump.edu.my/id/eprint/22204/1/52.%20Fabrication%20of%20bone%20scaffolds%20from%20Anadara%20granosa%20shell%20waste.pdf http://umpir.ump.edu.my/id/eprint/22204/2/52.1%20%20Fabrication%20of%20bone%20scaffolds%20from%20Anadara%20granosa%20shell%20waste.pdf

id	ump-22204
recordtype	eprints
spelling	ump-222042018-12-06T08:49:43Z http://umpir.ump.edu.my/id/eprint/22204/ Fabrication of bone scaffolds from Anadara Granosa shell waste Siti Hajar, Saharudin Jun Haslinda, Shariffuddin Noor Ida Amalina, Ahamad Nordin TP Chemical technology Bone defect and irregularities may cause by traumatic injuries or pathological condition such as osteoporosis and bone cancer [1-3]. In today’s medical practices, traditional treatment methods like autograft and allograft are still being used to treat the bone defect. However, these methods have some drawbacks such as insufficient bone donations, threat of donor-site morbidity and risk of disease transmission [4-6]. Currently, biomaterial scaffold has been widely explored to treat the defect where it serves as template for bone regeneration. On the other hand, the shell waste of Anadara granosa or known as cockle is biomaterial that are made up of more than 95% of calcium carbonate (CaCO3) and could have potential in bone engineering applications. Recent studies show that CaCO3 from molluscan shell has good osteoconductivity which can stimulate bone cell differentiation, induce bone formation and used as bone filling material [7, 8]. Thus, the aim of this study is to investigate the effect of cockle shell powder concentrations on physicochemical properties and bioactivity of the bone scaffold. The cockle shell powder were mixed with sodium alginate (SA) gel solution at ambient environment and lyophilized to obtained three dimensional bone scaffolds. The scaffolds were then physicochemically characterized using XRD, FTIR, SEM, EDX, universal testing machine, porosity and swelling percentage while its bioactivity were assessed using simulated body fluid (SBF) solution. As shown in XRD patterns (Fig. 1), the scaffolds that contained cockle shell powder has distinguished CaCO3 peak in the form of aragonite crystal. This indicates that the properties of the scaffold remain as CaCO3 which can be functional as biomaterial for bone applications. Previous studies done by Bharatham et al. [9] and Mahmood et al. [10] also reported parallel results. Subsequently, the comparison of scaffold morphologies containing 0%, 20% and 80% of cockle shell powder are shown in Fig. 2. The higher concentration of deposited cockle shell powder on the surface of sodium alginate network, the denser the scaffold morphology. This finding is aligned with our previous work where denser scaffolds have higher compressive strength [11]. Similar trends were also reported in Morsy et al. [12] as well as Chang and Zhang [13]. Additionally, EDX analyses show the presence of calcium element in the scaffolds containing cockle shell powder (Fig. 2(b) and 2(c)). This result can be correlated with XRD results in Fig. 1 where CaCO3 is the main element in the cockle shell powder. Overall, the addition of cockle shell powder into bone scaffold have improved the physicochemical properties and bioactivity of the scaffold. 2018-05 Conference or Workshop Item NonPeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/22204/1/52.%20Fabrication%20of%20bone%20scaffolds%20from%20Anadara%20granosa%20shell%20waste.pdf pdf en http://umpir.ump.edu.my/id/eprint/22204/2/52.1%20%20Fabrication%20of%20bone%20scaffolds%20from%20Anadara%20granosa%20shell%20waste.pdf Siti Hajar, Saharudin and Jun Haslinda, Shariffuddin and Noor Ida Amalina, Ahamad Nordin (2018) Fabrication of bone scaffolds from Anadara Granosa shell waste. In: 4th International Conference of Chemical Engineering & Industrial Biotechnology, 1-2 August 2018 , Seri Pacific Hotel, Kuala Lumpur. pp. 1-2.. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Siti Hajar, Saharudin Jun Haslinda, Shariffuddin Noor Ida Amalina, Ahamad Nordin Fabrication of bone scaffolds from Anadara Granosa shell waste
description	Bone defect and irregularities may cause by traumatic injuries or pathological condition such as osteoporosis and bone cancer [1-3]. In today’s medical practices, traditional treatment methods like autograft and allograft are still being used to treat the bone defect. However, these methods have some drawbacks such as insufficient bone donations, threat of donor-site morbidity and risk of disease transmission [4-6]. Currently, biomaterial scaffold has been widely explored to treat the defect where it serves as template for bone regeneration. On the other hand, the shell waste of Anadara granosa or known as cockle is biomaterial that are made up of more than 95% of calcium carbonate (CaCO3) and could have potential in bone engineering applications. Recent studies show that CaCO3 from molluscan shell has good osteoconductivity which can stimulate bone cell differentiation, induce bone formation and used as bone filling material [7, 8]. Thus, the aim of this study is to investigate the effect of cockle shell powder concentrations on physicochemical properties and bioactivity of the bone scaffold. The cockle shell powder were mixed with sodium alginate (SA) gel solution at ambient environment and lyophilized to obtained three dimensional bone scaffolds. The scaffolds were then physicochemically characterized using XRD, FTIR, SEM, EDX, universal testing machine, porosity and swelling percentage while its bioactivity were assessed using simulated body fluid (SBF) solution. As shown in XRD patterns (Fig. 1), the scaffolds that contained cockle shell powder has distinguished CaCO3 peak in the form of aragonite crystal. This indicates that the properties of the scaffold remain as CaCO3 which can be functional as biomaterial for bone applications. Previous studies done by Bharatham et al. [9] and Mahmood et al. [10] also reported parallel results. Subsequently, the comparison of scaffold morphologies containing 0%, 20% and 80% of cockle shell powder are shown in Fig. 2. The higher concentration of deposited cockle shell powder on the surface of sodium alginate network, the denser the scaffold morphology. This finding is aligned with our previous work where denser scaffolds have higher compressive strength [11]. Similar trends were also reported in Morsy et al. [12] as well as Chang and Zhang [13]. Additionally, EDX analyses show the presence of calcium element in the scaffolds containing cockle shell powder (Fig. 2(b) and 2(c)). This result can be correlated with XRD results in Fig. 1 where CaCO3 is the main element in the cockle shell powder. Overall, the addition of cockle shell powder into bone scaffold have improved the physicochemical properties and bioactivity of the scaffold.
format	Conference or Workshop Item
author	Siti Hajar, Saharudin Jun Haslinda, Shariffuddin Noor Ida Amalina, Ahamad Nordin
author_facet	Siti Hajar, Saharudin Jun Haslinda, Shariffuddin Noor Ida Amalina, Ahamad Nordin
author_sort	Siti Hajar, Saharudin
title	Fabrication of bone scaffolds from Anadara Granosa shell waste
title_short	Fabrication of bone scaffolds from Anadara Granosa shell waste
title_full	Fabrication of bone scaffolds from Anadara Granosa shell waste
title_fullStr	Fabrication of bone scaffolds from Anadara Granosa shell waste
title_full_unstemmed	Fabrication of bone scaffolds from Anadara Granosa shell waste
title_sort	fabrication of bone scaffolds from anadara granosa shell waste
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/22204/ http://umpir.ump.edu.my/id/eprint/22204/1/52.%20Fabrication%20of%20bone%20scaffolds%20from%20Anadara%20granosa%20shell%20waste.pdf http://umpir.ump.edu.my/id/eprint/22204/2/52.1%20%20Fabrication%20of%20bone%20scaffolds%20from%20Anadara%20granosa%20shell%20waste.pdf
first_indexed	2023-09-18T22:32:55Z
last_indexed	2023-09-18T22:32:55Z
_version_	1777416405706080256

Fabrication of bone scaffolds from Anadara Granosa shell waste

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