The effects of antifoam agent on dead end filtration process

The formation of foam as a result from introducing gases during cell culture process in the bioprocess industry has indirectly affected the throughput of the product of interest. Due to that, antifoams were developed and established as one of the means to minimize the formation of foam in the cell c...

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Main Authors:	S., Mohamad Pauzi, N., Ahmad, M. F., Yahya, Mohd Azmir, Arifin
Format:	Conference or Workshop Item
Language:	English English
Published:	IOP Publishing 2018
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/23020/ http://umpir.ump.edu.my/id/eprint/23020/ http://umpir.ump.edu.my/id/eprint/23020/1/The%20effects%20of%20antifoam%20agent%20on%20dead%20end%20filtration%20process.pdf http://umpir.ump.edu.my/id/eprint/23020/7/The%20Effects%20of%20Antifoam%20Agent%20on%20Dead%20End%20Filtration%20Process.pdf

id	ump-23020
recordtype	eprints
spelling	ump-230202018-12-07T08:14:38Z http://umpir.ump.edu.my/id/eprint/23020/ The effects of antifoam agent on dead end filtration process S., Mohamad Pauzi N., Ahmad M. F., Yahya Mohd Azmir, Arifin TP Chemical technology The formation of foam as a result from introducing gases during cell culture process in the bioprocess industry has indirectly affected the throughput of the product of interest. Due to that, antifoams were developed and established as one of the means to minimize the formation of foam in the cell culture. There are many types of antifoams but the silicone-type of antifoams are widely used in the bioprocess industry. Although the establishment of antifoam has aided the cell culture process, the impacts of its presence in the cell culture to the downstream process especially the dead end filtration is not widely discussed. The findings in the study emphasized on the dead end filtration performance that includes flux rate profile and the resulted filtration capacity. In this study, the concentrations of antifoam injected into the solution were varied from 0.2% v/v – 1.0% v/v and the solutions were filtered using constant flow method. The resulted maximum pressure readings and final flux rates indicated that the resistance exerted to the feed flow rate increased as the concentration of antifoam loaded in the solution increased. This later has led to the decline in the flux rates with percentage reduction between 32 – 68%. The calculated filter capacity for flux rate of 1000LMH ranged from 53 – 63L/m2 while it is in the range of 40 – 43L/m2 for flux rate of 2000LMH. The presence of antifoam agents in the feed load was determined to have negative effects on the dead end filtration performance and it may reduce the efficiency of the dead end filtration process. IOP Publishing 2018 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/23020/1/The%20effects%20of%20antifoam%20agent%20on%20dead%20end%20filtration%20process.pdf pdf en cc_by http://umpir.ump.edu.my/id/eprint/23020/7/The%20Effects%20of%20Antifoam%20Agent%20on%20Dead%20End%20Filtration%20Process.pdf S., Mohamad Pauzi and N., Ahmad and M. F., Yahya and Mohd Azmir, Arifin (2018) The effects of antifoam agent on dead end filtration process. In: 3rd International Conference on Global Sustainability and Chemical Engineering, ICGSCE 2017, 15-16 February 2017 , Marriot Hotel, Putrajaya; Malaysia. pp. 1-6., 358 (1). ISSN 1757-8981 (Print), 1757-899X (Online) https://doi.org/10.1088/1757-899X/358/1/012038
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	TP Chemical technology
spellingShingle	TP Chemical technology S., Mohamad Pauzi N., Ahmad M. F., Yahya Mohd Azmir, Arifin The effects of antifoam agent on dead end filtration process
description	The formation of foam as a result from introducing gases during cell culture process in the bioprocess industry has indirectly affected the throughput of the product of interest. Due to that, antifoams were developed and established as one of the means to minimize the formation of foam in the cell culture. There are many types of antifoams but the silicone-type of antifoams are widely used in the bioprocess industry. Although the establishment of antifoam has aided the cell culture process, the impacts of its presence in the cell culture to the downstream process especially the dead end filtration is not widely discussed. The findings in the study emphasized on the dead end filtration performance that includes flux rate profile and the resulted filtration capacity. In this study, the concentrations of antifoam injected into the solution were varied from 0.2% v/v – 1.0% v/v and the solutions were filtered using constant flow method. The resulted maximum pressure readings and final flux rates indicated that the resistance exerted to the feed flow rate increased as the concentration of antifoam loaded in the solution increased. This later has led to the decline in the flux rates with percentage reduction between 32 – 68%. The calculated filter capacity for flux rate of 1000LMH ranged from 53 – 63L/m2 while it is in the range of 40 – 43L/m2 for flux rate of 2000LMH. The presence of antifoam agents in the feed load was determined to have negative effects on the dead end filtration performance and it may reduce the efficiency of the dead end filtration process.
format	Conference or Workshop Item
author	S., Mohamad Pauzi N., Ahmad M. F., Yahya Mohd Azmir, Arifin
author_facet	S., Mohamad Pauzi N., Ahmad M. F., Yahya Mohd Azmir, Arifin
author_sort	S., Mohamad Pauzi
title	The effects of antifoam agent on dead end filtration process
title_short	The effects of antifoam agent on dead end filtration process
title_full	The effects of antifoam agent on dead end filtration process
title_fullStr	The effects of antifoam agent on dead end filtration process
title_full_unstemmed	The effects of antifoam agent on dead end filtration process
title_sort	effects of antifoam agent on dead end filtration process
publisher	IOP Publishing
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/23020/ http://umpir.ump.edu.my/id/eprint/23020/ http://umpir.ump.edu.my/id/eprint/23020/1/The%20effects%20of%20antifoam%20agent%20on%20dead%20end%20filtration%20process.pdf http://umpir.ump.edu.my/id/eprint/23020/7/The%20Effects%20of%20Antifoam%20Agent%20on%20Dead%20End%20Filtration%20Process.pdf
first_indexed	2023-09-18T22:34:19Z
last_indexed	2023-09-18T22:34:19Z
_version_	1777416493587234816

The effects of antifoam agent on dead end filtration process

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