Screening of carbamazepine-saccharin (CBC-SAC) co-crystal

Co-crystallization is a method in formulation of drug products which is believed to improve drugs solubility, stability and dissolution rate while maintaining the biological functions of its chemical properties. The recent advances in this area have brought this research possible in order to produce...

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Main Author:	Nur Amanina, Mohamad Adaris
Format:	Undergraduates Project Papers
Language:	English English English English
Published:	2017
Subjects:	QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/23519/ http://umpir.ump.edu.my/id/eprint/23519/ http://umpir.ump.edu.my/id/eprint/23519/1/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20Table%20of%20contents.pdf http://umpir.ump.edu.my/id/eprint/23519/2/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20Abstract.pdf http://umpir.ump.edu.my/id/eprint/23519/3/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20Chapter%201.pdf http://umpir.ump.edu.my/id/eprint/23519/4/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20References.pdf

id	ump-23519
recordtype	eprints
spelling	ump-235192018-12-31T04:13:35Z http://umpir.ump.edu.my/id/eprint/23519/ Screening of carbamazepine-saccharin (CBC-SAC) co-crystal Nur Amanina, Mohamad Adaris QD Chemistry Co-crystallization is a method in formulation of drug products which is believed to improve drugs solubility, stability and dissolution rate while maintaining the biological functions of its chemical properties. The recent advances in this area have brought this research possible in order to produce pharmaceutical material by crystallization design of carbamazepine (CBZ) using saccharin (SAC) as its co-crystal. This research is conducted to examine formation of carbamazepine-saccharin (CBZ-SAC) co-crystal screening approaches that uses different solvent based crystallization technique in varies solvent system (ethyl acetate solvent and formic acid solvent). In this method, to prepare the co-crystal product CBZ-SAC four crystallization technique are used which are cooling crystallization, solvent crystallization, slurry and stirring in varies solvent of ethyl acetate and formic acid. Different mol ratio of CBZ and SAC are being tested, in order to study CBZ-SAC co-crystal formation. Physical characterization of the co-crystal is being characterized by x-ray powder diffraction (XPRD), differential scanning calorimetry (DSC), fourier transform infrared spectroscopic (FTIR) and optical microscopic. The XPRD analysis had confirmed that only CBZ-SAC co-crystal in ethyl acetate solvent were successfully formed while in formic acid solvent the crystal formed were only SAC. The XRPD pattern profile analysis shown that CBZ-SAC Form I and Form II was produced from different ratios and different methods and it have their own melting point based from the DSC analysis which are 170-172°C and173-177°C respectively. The morphology of the crystal are mostly plate like and needle like shape which indicate Form I and Form II respectively for the polymorphic characterisation. Since two type of polymorph were successfully produced, it is shown that solvent, methods and ratios plays an important role to CBZ-SAC co-crystal formation. Further study in screening is needed for co-crystal formation assessment since there were already many factors proven in affecting the polymorphic formation of the co-crystal such as different methods, solvent and mole ratio. Besides that varies solvent type should be implemented to investigate if the solvent yield CBZ-SAC co-crystal formation and its polymorph. 2017-06 Undergraduates Project Papers NonPeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/23519/1/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20Table%20of%20contents.pdf pdf en http://umpir.ump.edu.my/id/eprint/23519/2/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20Abstract.pdf pdf en http://umpir.ump.edu.my/id/eprint/23519/3/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20Chapter%201.pdf pdf en http://umpir.ump.edu.my/id/eprint/23519/4/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20References.pdf Nur Amanina, Mohamad Adaris (2017) Screening of carbamazepine-saccharin (CBC-SAC) co-crystal. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang. http://iportal.ump.edu.my/lib/item?id=chamo:102948&theme=UMP2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English English English
topic	QD Chemistry
spellingShingle	QD Chemistry Nur Amanina, Mohamad Adaris Screening of carbamazepine-saccharin (CBC-SAC) co-crystal
description	Co-crystallization is a method in formulation of drug products which is believed to improve drugs solubility, stability and dissolution rate while maintaining the biological functions of its chemical properties. The recent advances in this area have brought this research possible in order to produce pharmaceutical material by crystallization design of carbamazepine (CBZ) using saccharin (SAC) as its co-crystal. This research is conducted to examine formation of carbamazepine-saccharin (CBZ-SAC) co-crystal screening approaches that uses different solvent based crystallization technique in varies solvent system (ethyl acetate solvent and formic acid solvent). In this method, to prepare the co-crystal product CBZ-SAC four crystallization technique are used which are cooling crystallization, solvent crystallization, slurry and stirring in varies solvent of ethyl acetate and formic acid. Different mol ratio of CBZ and SAC are being tested, in order to study CBZ-SAC co-crystal formation. Physical characterization of the co-crystal is being characterized by x-ray powder diffraction (XPRD), differential scanning calorimetry (DSC), fourier transform infrared spectroscopic (FTIR) and optical microscopic. The XPRD analysis had confirmed that only CBZ-SAC co-crystal in ethyl acetate solvent were successfully formed while in formic acid solvent the crystal formed were only SAC. The XRPD pattern profile analysis shown that CBZ-SAC Form I and Form II was produced from different ratios and different methods and it have their own melting point based from the DSC analysis which are 170-172°C and173-177°C respectively. The morphology of the crystal are mostly plate like and needle like shape which indicate Form I and Form II respectively for the polymorphic characterisation. Since two type of polymorph were successfully produced, it is shown that solvent, methods and ratios plays an important role to CBZ-SAC co-crystal formation. Further study in screening is needed for co-crystal formation assessment since there were already many factors proven in affecting the polymorphic formation of the co-crystal such as different methods, solvent and mole ratio. Besides that varies solvent type should be implemented to investigate if the solvent yield CBZ-SAC co-crystal formation and its polymorph.
format	Undergraduates Project Papers
author	Nur Amanina, Mohamad Adaris
author_facet	Nur Amanina, Mohamad Adaris
author_sort	Nur Amanina, Mohamad Adaris
title	Screening of carbamazepine-saccharin (CBC-SAC) co-crystal
title_short	Screening of carbamazepine-saccharin (CBC-SAC) co-crystal
title_full	Screening of carbamazepine-saccharin (CBC-SAC) co-crystal
title_fullStr	Screening of carbamazepine-saccharin (CBC-SAC) co-crystal
title_full_unstemmed	Screening of carbamazepine-saccharin (CBC-SAC) co-crystal
title_sort	screening of carbamazepine-saccharin (cbc-sac) co-crystal
publishDate	2017
url	http://umpir.ump.edu.my/id/eprint/23519/ http://umpir.ump.edu.my/id/eprint/23519/ http://umpir.ump.edu.my/id/eprint/23519/1/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20Table%20of%20contents.pdf http://umpir.ump.edu.my/id/eprint/23519/2/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20Abstract.pdf http://umpir.ump.edu.my/id/eprint/23519/3/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20Chapter%201.pdf http://umpir.ump.edu.my/id/eprint/23519/4/Screening%20of%20carbamazepine-saccharin%20%28CBC-SAC%29%20co-crystal%20-%20References.pdf
first_indexed	2023-09-18T22:35:15Z
last_indexed	2023-09-18T22:35:15Z
_version_	1777416552169078784

Screening of carbamazepine-saccharin (CBC-SAC) co-crystal

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