Development and characterization of a theranostic micelles system using TPGS with docetaxel and coumarin-6: a dual polymeric nanocarrier system

Theranostic micelles and polymeric nanocarrier-based drug delivery system are well known techniques that involve a diagnostic agent in polymeric micelles for a combination of therapy by using a co-delivery approach which can help in detection of a cancer cell in an early stage, increase killing effe...

Full description

Bibliographic Details
Main Authors:	Ching, L.H., Mahmood, Syed, Raihana Z., Edros, Rajaletchumy, Veloo Kutty
Format:	Article
Language:	English
Published:	Universiti Malaysia Pahang 2018
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://umpir.ump.edu.my/id/eprint/23773/ http://umpir.ump.edu.my/id/eprint/23773/ http://umpir.ump.edu.my/id/eprint/23773/1/Development%20and%20Characterization%20of%20a%20Theranostic%20Micelles%20System%20using%20TPGS.pdf

id	ump-23773
recordtype	eprints
spelling	ump-237732019-03-04T03:17:51Z http://umpir.ump.edu.my/id/eprint/23773/ Development and characterization of a theranostic micelles system using TPGS with docetaxel and coumarin-6: a dual polymeric nanocarrier system Ching, L.H. Mahmood, Syed Raihana Z., Edros Rajaletchumy, Veloo Kutty RM Therapeutics. Pharmacology Theranostic micelles and polymeric nanocarrier-based drug delivery system are well known techniques that involve a diagnostic agent in polymeric micelles for a combination of therapy by using a co-delivery approach which can help in detection of a cancer cell in an early stage, increase killing effect and suppress multi-drug resistance (MDS) for better therapeutic effectiveness. The aim of this study is to develop a dual modality micellar system using D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as a nanocarrier for co-delivery of docetaxel as a model chemotherapeutic drug and coumarin-6 as a model fluorescence imaging agent for simultaneous cancer imaging and therapy in an early stage. The theranostic micelles were prepared by a solvent casting method and characterized by their particle size, drug loading, drug encapsulation efficiency (EE) and in-vitro drug release profile. These dual modality micellar system TPDC6 micelles were successfully developed with average particle size of 79.59±0.57 nm in diameter and drug loading up to 15.46±1.02 (EE of 78.99±1.26) and 9.83±0.76 (EE of 36.20±0.89) for docetaxel and coumarin-6 respectively. Besides, the in-vitro drug release profile of the micelles revealed a desired sustained and controlled drug release manner for both docetaxel (21.62±0.36) and coumarin-6 (10.70±0.46). In conclusion, the micelles size obtained is in the favourable range for passive targeting through enhanced permeability and retention (EPR) effect and the drug loading and encapsulation efficiency attained are adequate for therapy and diagnosis purposes on cancer cells. This dual modality system is taking great advantages for tumour imaging and inhibition of tumour growth which is very important for early cancer detection. Universiti Malaysia Pahang 2018-06 Article PeerReviewed pdf en cc_by_nc_4 http://umpir.ump.edu.my/id/eprint/23773/1/Development%20and%20Characterization%20of%20a%20Theranostic%20Micelles%20System%20using%20TPGS.pdf Ching, L.H. and Mahmood, Syed and Raihana Z., Edros and Rajaletchumy, Veloo Kutty (2018) Development and characterization of a theranostic micelles system using TPGS with docetaxel and coumarin-6: a dual polymeric nanocarrier system. International Journal of Engineering Technology and Sciences, 5 (1). pp. 1-10. ISSN 2289-697X (Print); ISSN: 2462-1269 (Online) http://ojs.ump.edu.my/ojs3/index.php/IJETS/article/view/241
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Ching, L.H. Mahmood, Syed Raihana Z., Edros Rajaletchumy, Veloo Kutty Development and characterization of a theranostic micelles system using TPGS with docetaxel and coumarin-6: a dual polymeric nanocarrier system
description	Theranostic micelles and polymeric nanocarrier-based drug delivery system are well known techniques that involve a diagnostic agent in polymeric micelles for a combination of therapy by using a co-delivery approach which can help in detection of a cancer cell in an early stage, increase killing effect and suppress multi-drug resistance (MDS) for better therapeutic effectiveness. The aim of this study is to develop a dual modality micellar system using D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as a nanocarrier for co-delivery of docetaxel as a model chemotherapeutic drug and coumarin-6 as a model fluorescence imaging agent for simultaneous cancer imaging and therapy in an early stage. The theranostic micelles were prepared by a solvent casting method and characterized by their particle size, drug loading, drug encapsulation efficiency (EE) and in-vitro drug release profile. These dual modality micellar system TPDC6 micelles were successfully developed with average particle size of 79.59±0.57 nm in diameter and drug loading up to 15.46±1.02 (EE of 78.99±1.26) and 9.83±0.76 (EE of 36.20±0.89) for docetaxel and coumarin-6 respectively. Besides, the in-vitro drug release profile of the micelles revealed a desired sustained and controlled drug release manner for both docetaxel (21.62±0.36) and coumarin-6 (10.70±0.46). In conclusion, the micelles size obtained is in the favourable range for passive targeting through enhanced permeability and retention (EPR) effect and the drug loading and encapsulation efficiency attained are adequate for therapy and diagnosis purposes on cancer cells. This dual modality system is taking great advantages for tumour imaging and inhibition of tumour growth which is very important for early cancer detection.
format	Article
author	Ching, L.H. Mahmood, Syed Raihana Z., Edros Rajaletchumy, Veloo Kutty
author_facet	Ching, L.H. Mahmood, Syed Raihana Z., Edros Rajaletchumy, Veloo Kutty
author_sort	Ching, L.H.
title	Development and characterization of a theranostic micelles system using TPGS with docetaxel and coumarin-6: a dual polymeric nanocarrier system
title_short	Development and characterization of a theranostic micelles system using TPGS with docetaxel and coumarin-6: a dual polymeric nanocarrier system
title_full	Development and characterization of a theranostic micelles system using TPGS with docetaxel and coumarin-6: a dual polymeric nanocarrier system
title_fullStr	Development and characterization of a theranostic micelles system using TPGS with docetaxel and coumarin-6: a dual polymeric nanocarrier system
title_full_unstemmed	Development and characterization of a theranostic micelles system using TPGS with docetaxel and coumarin-6: a dual polymeric nanocarrier system
title_sort	development and characterization of a theranostic micelles system using tpgs with docetaxel and coumarin-6: a dual polymeric nanocarrier system
publisher	Universiti Malaysia Pahang
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/23773/ http://umpir.ump.edu.my/id/eprint/23773/ http://umpir.ump.edu.my/id/eprint/23773/1/Development%20and%20Characterization%20of%20a%20Theranostic%20Micelles%20System%20using%20TPGS.pdf
first_indexed	2023-09-18T22:35:45Z
last_indexed	2023-09-18T22:35:45Z
_version_	1777416584065712128

Development and characterization of a theranostic micelles system using TPGS with docetaxel and coumarin-6: a dual polymeric nanocarrier system

Similar Items