Selective arylation of phenol protected propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and their pharmacological aspects

Biaryls are the potential source of synthetic drugs. The present study describes the synthesis of a series of functionalized biphenyl derivatives (3a-3g) using Pd-catalyzed Suzuki coupling reaction. The experimental results revealed the facile synthesis of biphenyl derivatives (3a-3g) with notably h...

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Main Authors:	Farooq, Hira, Rasool, Nasir, Ansari, Muhammad Tayyab, Rizwan, Komal, Iqbal, Sarosh, Mahmood, Tariq, Israr, Hira, Ayub, Khurshid, Rasheed, Tahir, Seema, Zareen, Akhtar, Muhammad Nadeem
Format:	Article
Language:	English
Published:	Polish Pharmaceutical Society 2018
Subjects:	QD Chemistry QR Microbiology
Online Access:	http://umpir.ump.edu.my/id/eprint/23928/ http://umpir.ump.edu.my/id/eprint/23928/ http://umpir.ump.edu.my/id/eprint/23928/ http://umpir.ump.edu.my/id/eprint/23928/1/Selective%20arylation%20of%20phenol%20protecteddone.pdf

id	ump-23928
recordtype	eprints
spelling	ump-239282019-04-02T04:46:27Z http://umpir.ump.edu.my/id/eprint/23928/ Selective arylation of phenol protected propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and their pharmacological aspects Farooq, Hira Rasool, Nasir Ansari, Muhammad Tayyab Rizwan, Komal Iqbal, Sarosh Mahmood, Tariq Israr, Hira Ayub, Khurshid Rasheed, Tahir Seema, Zareen Akhtar, Muhammad Nadeem QD Chemistry QR Microbiology Biaryls are the potential source of synthetic drugs. The present study describes the synthesis of a series of functionalized biphenyl derivatives (3a-3g) using Pd-catalyzed Suzuki coupling reaction. The experimental results revealed the facile synthesis of biphenyl derivatives (3a-3g) with notably high yield (80-88%). Density functional theory (DFT) studies were performed by Gaussian 09 software in order to rationalize the selectivity of coupling at C-Br bond instead of C-Cl bond. In addition of synthesis, the biological activities (biofilm inhibition, hemolytic and anti-thrombolytic) of these novel compounds were investigated. These results exhibited good biofilm inhibition (5.86-65.8%), hemolytic (1.32-30.1%) and anti-thrombolytic activities (9.64-42.5%), indicating the potential use of these compounds for pharmaceutical applications Polish Pharmaceutical Society 2018 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/23928/1/Selective%20arylation%20of%20phenol%20protecteddone.pdf Farooq, Hira and Rasool, Nasir and Ansari, Muhammad Tayyab and Rizwan, Komal and Iqbal, Sarosh and Mahmood, Tariq and Israr, Hira and Ayub, Khurshid and Rasheed, Tahir and Seema, Zareen and Akhtar, Muhammad Nadeem (2018) Selective arylation of phenol protected propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and their pharmacological aspects. Acta Poloniae Pharmaceutica - Drug Research, 75 (4). pp. 911-919. ISSN 0001-6837 http://ptfarm.pl/en/wydawnictwa/czasopisma/acta-poloniae-pharmaceutica/110/-/27641 DOI: 10.32383/appdr/78920
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry QR Microbiology
spellingShingle	QD Chemistry QR Microbiology Farooq, Hira Rasool, Nasir Ansari, Muhammad Tayyab Rizwan, Komal Iqbal, Sarosh Mahmood, Tariq Israr, Hira Ayub, Khurshid Rasheed, Tahir Seema, Zareen Akhtar, Muhammad Nadeem Selective arylation of phenol protected propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and their pharmacological aspects
description	Biaryls are the potential source of synthetic drugs. The present study describes the synthesis of a series of functionalized biphenyl derivatives (3a-3g) using Pd-catalyzed Suzuki coupling reaction. The experimental results revealed the facile synthesis of biphenyl derivatives (3a-3g) with notably high yield (80-88%). Density functional theory (DFT) studies were performed by Gaussian 09 software in order to rationalize the selectivity of coupling at C-Br bond instead of C-Cl bond. In addition of synthesis, the biological activities (biofilm inhibition, hemolytic and anti-thrombolytic) of these novel compounds were investigated. These results exhibited good biofilm inhibition (5.86-65.8%), hemolytic (1.32-30.1%) and anti-thrombolytic activities (9.64-42.5%), indicating the potential use of these compounds for pharmaceutical applications
format	Article
author	Farooq, Hira Rasool, Nasir Ansari, Muhammad Tayyab Rizwan, Komal Iqbal, Sarosh Mahmood, Tariq Israr, Hira Ayub, Khurshid Rasheed, Tahir Seema, Zareen Akhtar, Muhammad Nadeem
author_facet	Farooq, Hira Rasool, Nasir Ansari, Muhammad Tayyab Rizwan, Komal Iqbal, Sarosh Mahmood, Tariq Israr, Hira Ayub, Khurshid Rasheed, Tahir Seema, Zareen Akhtar, Muhammad Nadeem
author_sort	Farooq, Hira
title	Selective arylation of phenol protected propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and their pharmacological aspects
title_short	Selective arylation of phenol protected propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and their pharmacological aspects
title_full	Selective arylation of phenol protected propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and their pharmacological aspects
title_fullStr	Selective arylation of phenol protected propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and their pharmacological aspects
title_full_unstemmed	Selective arylation of phenol protected propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and their pharmacological aspects
title_sort	selective arylation of phenol protected propygyl bromide via pd-catalysed suzuki coupling reaction: synthesis, mechanistic studies by dft calculations and their pharmacological aspects
publisher	Polish Pharmaceutical Society
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/23928/ http://umpir.ump.edu.my/id/eprint/23928/ http://umpir.ump.edu.my/id/eprint/23928/ http://umpir.ump.edu.my/id/eprint/23928/1/Selective%20arylation%20of%20phenol%20protecteddone.pdf
first_indexed	2023-09-18T22:36:03Z
last_indexed	2023-09-18T22:36:03Z
_version_	1777416602311983104

Selective arylation of phenol protected propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and their pharmacological aspects

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