Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability

This study aimed to formulate and characterize microemulsions containing chloramphenicol. Microemulsions represent highly biocompatible drug delivery systems due to their potential for increased absorption as well as high solubilization capacity. MEs were composed of Oleic acid, non-ionic surfactant...

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Main Authors:	Rashid, Muhammad Abid, Naza, Tehreem, Abbas, Madeeha, Nazir, Sadia, Younas, Nafisa, Majeed, Sana, Qureshi, Naseem, Akhtar, Muhammad Nadeem
Format:	Article
Language:	English
Published:	Elsevier 2019
Subjects:	QR Microbiology
Online Access:	http://umpir.ump.edu.my/id/eprint/23931/ http://umpir.ump.edu.my/id/eprint/23931/ http://umpir.ump.edu.my/id/eprint/23931/ http://umpir.ump.edu.my/id/eprint/23931/1/Chloramphenicol%20Loaded%20Microemulsions.pdf

id	ump-23931
recordtype	eprints
spelling	ump-239312019-01-23T08:21:16Z http://umpir.ump.edu.my/id/eprint/23931/ Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability Rashid, Muhammad Abid Naza, Tehreem Abbas, Madeeha Nazir, Sadia Younas, Nafisa Majeed, Sana Qureshi, Naseem Akhtar, Muhammad Nadeem QR Microbiology This study aimed to formulate and characterize microemulsions containing chloramphenicol. Microemulsions represent highly biocompatible drug delivery systems due to their potential for increased absorption as well as high solubilization capacity. MEs were composed of Oleic acid, non-ionic surfactants tween 20/60, 1-propanol and phosphate buffer. The optimum weight ratios of components and MEs areas were determined by pseudo-ternary phase diagram. All formulations were physically characterized by centrifugation, pH, refractive index, conductivity, viscosity, surface tension and partition coefficient. The specific residence site of chloramphenicol was detected by 1H NMR study. It was uncovered that drug is entrapped between the oxyethylene groups of hydrophilic shell of MEs. So, the drug was screened from bulk water and its stability was enhanced. Thus, all characterizations have suggested that formulated MEs have potential for ocular application, being able to use as efficient drug carrier for ocular drug delivery. Elsevier 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/23931/1/Chloramphenicol%20Loaded%20Microemulsions.pdf Rashid, Muhammad Abid and Naza, Tehreem and Abbas, Madeeha and Nazir, Sadia and Younas, Nafisa and Majeed, Sana and Qureshi, Naseem and Akhtar, Muhammad Nadeem (2019) Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability. Colloid and Interface Science Communications, 28. pp. 41-48. ISSN 2215-0382 https://doi.org/10.1016/j.colcom.2018.11.006 https://doi.org/10.1016/j.colcom.2018.11.006
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QR Microbiology
spellingShingle	QR Microbiology Rashid, Muhammad Abid Naza, Tehreem Abbas, Madeeha Nazir, Sadia Younas, Nafisa Majeed, Sana Qureshi, Naseem Akhtar, Muhammad Nadeem Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
description	This study aimed to formulate and characterize microemulsions containing chloramphenicol. Microemulsions represent highly biocompatible drug delivery systems due to their potential for increased absorption as well as high solubilization capacity. MEs were composed of Oleic acid, non-ionic surfactants tween 20/60, 1-propanol and phosphate buffer. The optimum weight ratios of components and MEs areas were determined by pseudo-ternary phase diagram. All formulations were physically characterized by centrifugation, pH, refractive index, conductivity, viscosity, surface tension and partition coefficient. The specific residence site of chloramphenicol was detected by 1H NMR study. It was uncovered that drug is entrapped between the oxyethylene groups of hydrophilic shell of MEs. So, the drug was screened from bulk water and its stability was enhanced. Thus, all characterizations have suggested that formulated MEs have potential for ocular application, being able to use as efficient drug carrier for ocular drug delivery.
format	Article
author	Rashid, Muhammad Abid Naza, Tehreem Abbas, Madeeha Nazir, Sadia Younas, Nafisa Majeed, Sana Qureshi, Naseem Akhtar, Muhammad Nadeem
author_facet	Rashid, Muhammad Abid Naza, Tehreem Abbas, Madeeha Nazir, Sadia Younas, Nafisa Majeed, Sana Qureshi, Naseem Akhtar, Muhammad Nadeem
author_sort	Rashid, Muhammad Abid
title	Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
title_short	Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
title_full	Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
title_fullStr	Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
title_full_unstemmed	Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability
title_sort	chloramphenicol loaded microemulsions: development, characterization and stability
publisher	Elsevier
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/23931/ http://umpir.ump.edu.my/id/eprint/23931/ http://umpir.ump.edu.my/id/eprint/23931/ http://umpir.ump.edu.my/id/eprint/23931/1/Chloramphenicol%20Loaded%20Microemulsions.pdf
first_indexed	2023-09-18T22:36:03Z
last_indexed	2023-09-18T22:36:03Z
_version_	1777416602752385024

Chloramphenicol Loaded Microemulsions: Development, Characterization and Stability

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