In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities

The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to s...

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Main Authors:	Azad, A. K., Laboni, Farhina Rahman, Rashid, Harun, Ferdous, Sahena, Rashid, Shah Samiur, Nurkhalida, Kamal, Labu, Zubair Khalid, Islam, M. S., Sarker, Zaidul Islam
Format:	Article
Language:	English
Published:	Taylor & Francis 2018
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/24086/ http://umpir.ump.edu.my/id/eprint/24086/ http://umpir.ump.edu.my/id/eprint/24086/ http://umpir.ump.edu.my/id/eprint/24086/1/In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb1.pdf

id	ump-24086
recordtype	eprints
spelling	ump-240862019-02-11T02:35:16Z http://umpir.ump.edu.my/id/eprint/24086/ In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities Azad, A. K. Laboni, Farhina Rahman Rashid, Harun Ferdous, Sahena Rashid, Shah Samiur Nurkhalida, Kamal Labu, Zubair Khalid Islam, M. S. Sarker, Zaidul Islam TP Chemical technology The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83 μg/mL while the standard ascorbic acid was 2.48 µg/mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p > 0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50 mg of GAE/g). Taylor & Francis 2018 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24086/1/In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb1.pdf Azad, A. K. and Laboni, Farhina Rahman and Rashid, Harun and Ferdous, Sahena and Rashid, Shah Samiur and Nurkhalida, Kamal and Labu, Zubair Khalid and Islam, M. S. and Sarker, Zaidul Islam (2018) In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities. Natural Product Research: Formerly Natural Product Letters. pp. 1-4. ISSN 1478-6419 (print); 1478-6427 (online) (In Press) https://doi.org/10.1080/14786419.2018.1538216 https://doi.org/10.1080/14786419.2018.1538216
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Azad, A. K. Laboni, Farhina Rahman Rashid, Harun Ferdous, Sahena Rashid, Shah Samiur Nurkhalida, Kamal Labu, Zubair Khalid Islam, M. S. Sarker, Zaidul Islam In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities
description	The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83 μg/mL while the standard ascorbic acid was 2.48 µg/mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p > 0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50 mg of GAE/g).
format	Article
author	Azad, A. K. Laboni, Farhina Rahman Rashid, Harun Ferdous, Sahena Rashid, Shah Samiur Nurkhalida, Kamal Labu, Zubair Khalid Islam, M. S. Sarker, Zaidul Islam
author_facet	Azad, A. K. Laboni, Farhina Rahman Rashid, Harun Ferdous, Sahena Rashid, Shah Samiur Nurkhalida, Kamal Labu, Zubair Khalid Islam, M. S. Sarker, Zaidul Islam
author_sort	Azad, A. K.
title	In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities
title_short	In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities
title_full	In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities
title_fullStr	In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities
title_full_unstemmed	In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities
title_sort	in vitro evaluation of cuscuta reflexa roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities
publisher	Taylor & Francis
publishDate	2018
url	http://umpir.ump.edu.my/id/eprint/24086/ http://umpir.ump.edu.my/id/eprint/24086/ http://umpir.ump.edu.my/id/eprint/24086/ http://umpir.ump.edu.my/id/eprint/24086/1/In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb1.pdf
first_indexed	2023-09-18T22:36:17Z
last_indexed	2023-09-18T22:36:17Z
_version_	1777416617135702016

In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities

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