Investigation of mixing time on carrageenan cellulose nanocrystals (CNC) hard capsule for drug delivery carrier

Investigation of mixing time on carrageenan cellulose nanocrystals (CNC) hard capsule for drug delivery carrier

Present global market demands for plant based capsule to replace the animal based product. However, plant capsule produces a lower mechanical strength in comparison to gelatin based capsule. In this work, at constant 65 °C mixing temperature, the solution mixing time was varied to investigate the fi...

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Main Authors: Mohd Aiman, Hamdan, Fatmawati, Adam, Khairatun Najwa, Mohd Amin
Format: Article
Language:English
Published: IJISRT 2018
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/24427/
http://umpir.ump.edu.my/id/eprint/24427/
http://umpir.ump.edu.my/id/eprint/24427/1/Investigation%20of%20mixing%20time%20on%20CarrageenanCellulose%20Nanocrystals%20%28CNC%29%20hard%20capsule%20for%20drug%20delivery%20carrier.pdf
id ump-24427
recordtype eprints
spelling ump-244272020-02-21T03:51:42Z http://umpir.ump.edu.my/id/eprint/24427/ Investigation of mixing time on carrageenan cellulose nanocrystals (CNC) hard capsule for drug delivery carrier Mohd Aiman, Hamdan Fatmawati, Adam Khairatun Najwa, Mohd Amin TP Chemical technology Present global market demands for plant based capsule to replace the animal based product. However, plant capsule produces a lower mechanical strength in comparison to gelatin based capsule. In this work, at constant 65 °C mixing temperature, the solution mixing time was varied to investigate the final carrageenan-CNC hard capsule mechanical properties, moisture content and chemical properties. The mixing time increased the solution viscosity and mechanical strength of hard capsule, while reduced the moisture content of the product. High tensile strength was obtained at higher mixing time might indicates uniform dispersion of CNC and increment of hydroxyl bonding in the carrageenan matrix. The disintegration time of hard capsule starts to rupture also increased as the mixing time increased but still disintegrated in less than 15 minutes. IJISRT 2018 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24427/1/Investigation%20of%20mixing%20time%20on%20CarrageenanCellulose%20Nanocrystals%20%28CNC%29%20hard%20capsule%20for%20drug%20delivery%20carrier.pdf Mohd Aiman, Hamdan and Fatmawati, Adam and Khairatun Najwa, Mohd Amin (2018) Investigation of mixing time on carrageenan cellulose nanocrystals (CNC) hard capsule for drug delivery carrier. International Journal of Innovative Science and Research Technology, 3 (1). pp. 457-461. ISSN 2456-2165 http://ijisrt.com/wp-content/uploads/2018/02/Investigation-of-Mixing-Time-on-Carrageenan-Cellulose-Nanocrystals-CNC-Hard-Capsule-for-Drug-Delivery-Carrier-1.pdf
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Mohd Aiman, Hamdan
Fatmawati, Adam
Khairatun Najwa, Mohd Amin
Investigation of mixing time on carrageenan cellulose nanocrystals (CNC) hard capsule for drug delivery carrier
description Present global market demands for plant based capsule to replace the animal based product. However, plant capsule produces a lower mechanical strength in comparison to gelatin based capsule. In this work, at constant 65 °C mixing temperature, the solution mixing time was varied to investigate the final carrageenan-CNC hard capsule mechanical properties, moisture content and chemical properties. The mixing time increased the solution viscosity and mechanical strength of hard capsule, while reduced the moisture content of the product. High tensile strength was obtained at higher mixing time might indicates uniform dispersion of CNC and increment of hydroxyl bonding in the carrageenan matrix. The disintegration time of hard capsule starts to rupture also increased as the mixing time increased but still disintegrated in less than 15 minutes.
format Article
author Mohd Aiman, Hamdan
Fatmawati, Adam
Khairatun Najwa, Mohd Amin
author_facet Mohd Aiman, Hamdan
Fatmawati, Adam
Khairatun Najwa, Mohd Amin
author_sort Mohd Aiman, Hamdan
title Investigation of mixing time on carrageenan cellulose nanocrystals (CNC) hard capsule for drug delivery carrier
title_short Investigation of mixing time on carrageenan cellulose nanocrystals (CNC) hard capsule for drug delivery carrier
title_full Investigation of mixing time on carrageenan cellulose nanocrystals (CNC) hard capsule for drug delivery carrier
title_fullStr Investigation of mixing time on carrageenan cellulose nanocrystals (CNC) hard capsule for drug delivery carrier
title_full_unstemmed Investigation of mixing time on carrageenan cellulose nanocrystals (CNC) hard capsule for drug delivery carrier
title_sort investigation of mixing time on carrageenan cellulose nanocrystals (cnc) hard capsule for drug delivery carrier
publisher IJISRT
publishDate 2018
url http://umpir.ump.edu.my/id/eprint/24427/
http://umpir.ump.edu.my/id/eprint/24427/
http://umpir.ump.edu.my/id/eprint/24427/1/Investigation%20of%20mixing%20time%20on%20CarrageenanCellulose%20Nanocrystals%20%28CNC%29%20hard%20capsule%20for%20drug%20delivery%20carrier.pdf
first_indexed 2023-09-18T22:36:57Z
last_indexed 2023-09-18T22:36:57Z
_version_ 1777416659800162304

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