Effects of Brain Tissue Mechanical and Fluid Transport Properties during Ischaemic Brain Oedema: A Poroelastic Finite Element Analysis

Reperfusion after ischaemic stroke is risky as it can result in the formation of brain oedema and brain tissue swelling, which subsequently leads to brain herniation. Brain herniation is an undesirable condition that may affect brain functionality and fatality. A mathematical model based on poroelas...

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Main Authors:	Mohd Jamil Mohamed, Mokhtarudin, Shabudin, Abbas, Payne, Stephen J.
Format:	Conference or Workshop Item
Language:	English
Published:	IEEE 2019
Subjects:	TJ Mechanical engineering and machinery
Online Access:	http://umpir.ump.edu.my/id/eprint/24567/ http://umpir.ump.edu.my/id/eprint/24567/ http://umpir.ump.edu.my/id/eprint/24567/13/Effects%20of%20brain%20tissue%20mechanical%20and%20fluid1.pdf

id	ump-24567
recordtype	eprints
spelling	ump-245672019-10-18T01:46:48Z http://umpir.ump.edu.my/id/eprint/24567/ Effects of Brain Tissue Mechanical and Fluid Transport Properties during Ischaemic Brain Oedema: A Poroelastic Finite Element Analysis Mohd Jamil Mohamed, Mokhtarudin Shabudin, Abbas Payne, Stephen J. TJ Mechanical engineering and machinery Reperfusion after ischaemic stroke is risky as it can result in the formation of brain oedema and brain tissue swelling, which subsequently leads to brain herniation. Brain herniation is an undesirable condition that may affect brain functionality and fatality. A mathematical model based on poroelastic model has been previously developed to describe brain oedema formation. In that model, the brain tissue is assumed as a homogeneous isotropic material. In this paper, the effects of the brain mechanical and fluid transport properties on brain oedema progression are investigated by solving the model in a realistic brain geometry using finite element scheme. Four model parameters, namely brain tissue Young's modulus, Poisson's ratio, water permeability, and viscosity are varied so that their effect on brain oedema formation can be investigated. The results show that the brain Young's modulus and Poisson's ratio play more important role in brain oedema formation compared to the water permeability and viscosity, when varying within certain limits. From these findings, the brain tissue mechanical properties must be optimized so that the model can be used extensively for patient-specific brain oedema progression prediction. IEEE 2019-12 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24567/13/Effects%20of%20brain%20tissue%20mechanical%20and%20fluid1.pdf Mohd Jamil Mohamed, Mokhtarudin and Shabudin, Abbas and Payne, Stephen J. (2019) Effects of Brain Tissue Mechanical and Fluid Transport Properties during Ischaemic Brain Oedema: A Poroelastic Finite Element Analysis. In: IEEE-EMBS Conference on Biomedical Engineering And Sciences (IECBES 2018), 3-6 December 2018 , Borneo Convention Centre Kuching, Sarawak, Malaysia. pp. 1-6.. ISBN 978-1-5386-2471-5 https://doi.org/10.1109/IECBES.2018.8626659
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TJ Mechanical engineering and machinery
spellingShingle	TJ Mechanical engineering and machinery Mohd Jamil Mohamed, Mokhtarudin Shabudin, Abbas Payne, Stephen J. Effects of Brain Tissue Mechanical and Fluid Transport Properties during Ischaemic Brain Oedema: A Poroelastic Finite Element Analysis
description	Reperfusion after ischaemic stroke is risky as it can result in the formation of brain oedema and brain tissue swelling, which subsequently leads to brain herniation. Brain herniation is an undesirable condition that may affect brain functionality and fatality. A mathematical model based on poroelastic model has been previously developed to describe brain oedema formation. In that model, the brain tissue is assumed as a homogeneous isotropic material. In this paper, the effects of the brain mechanical and fluid transport properties on brain oedema progression are investigated by solving the model in a realistic brain geometry using finite element scheme. Four model parameters, namely brain tissue Young's modulus, Poisson's ratio, water permeability, and viscosity are varied so that their effect on brain oedema formation can be investigated. The results show that the brain Young's modulus and Poisson's ratio play more important role in brain oedema formation compared to the water permeability and viscosity, when varying within certain limits. From these findings, the brain tissue mechanical properties must be optimized so that the model can be used extensively for patient-specific brain oedema progression prediction.
format	Conference or Workshop Item
author	Mohd Jamil Mohamed, Mokhtarudin Shabudin, Abbas Payne, Stephen J.
author_facet	Mohd Jamil Mohamed, Mokhtarudin Shabudin, Abbas Payne, Stephen J.
author_sort	Mohd Jamil Mohamed, Mokhtarudin
title	Effects of Brain Tissue Mechanical and Fluid Transport Properties during Ischaemic Brain Oedema: A Poroelastic Finite Element Analysis
title_short	Effects of Brain Tissue Mechanical and Fluid Transport Properties during Ischaemic Brain Oedema: A Poroelastic Finite Element Analysis
title_full	Effects of Brain Tissue Mechanical and Fluid Transport Properties during Ischaemic Brain Oedema: A Poroelastic Finite Element Analysis
title_fullStr	Effects of Brain Tissue Mechanical and Fluid Transport Properties during Ischaemic Brain Oedema: A Poroelastic Finite Element Analysis
title_full_unstemmed	Effects of Brain Tissue Mechanical and Fluid Transport Properties during Ischaemic Brain Oedema: A Poroelastic Finite Element Analysis
title_sort	effects of brain tissue mechanical and fluid transport properties during ischaemic brain oedema: a poroelastic finite element analysis
publisher	IEEE
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/24567/ http://umpir.ump.edu.my/id/eprint/24567/ http://umpir.ump.edu.my/id/eprint/24567/13/Effects%20of%20brain%20tissue%20mechanical%20and%20fluid1.pdf
first_indexed	2023-09-18T22:37:15Z
last_indexed	2023-09-18T22:37:15Z
_version_	1777416678625247232

Effects of Brain Tissue Mechanical and Fluid Transport Properties during Ischaemic Brain Oedema: A Poroelastic Finite Element Analysis

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