Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine

Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine

This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA-g-CdTe) quantum dots (QDs) via surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coa...

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Main Authors: Trinh Duy, Nguyen, Hieu, Vu-Quang, Thanh, Sang Vo, Duy, Chinh Nguyen, Dai-Viet, N. Vo, Dai Hai, Nguyen, Kwon, Taek Lim, Dai, Lam Tran, Long, Giang Bach
Format: Article
Language:English
Published: MDPI 2019
Subjects:
QD Chemistry
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/24748/
http://umpir.ump.edu.my/id/eprint/24748/
http://umpir.ump.edu.my/id/eprint/24748/
http://umpir.ump.edu.my/id/eprint/24748/1/Chemical%20Synthesis%20and%20Characterization%20of.pdf
id ump-24748
recordtype eprints
spelling ump-247482019-04-19T07:59:46Z http://umpir.ump.edu.my/id/eprint/24748/ Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine Trinh Duy, Nguyen Hieu, Vu-Quang Thanh, Sang Vo Duy, Chinh Nguyen Dai-Viet, N. Vo Dai Hai, Nguyen Kwon, Taek Lim Dai, Lam Tran Long, Giang Bach QD Chemistry TP Chemical technology This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA-g-CdTe) quantum dots (QDs) via surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coated CdTe QDs, synthesized using 2-mercaptoethanol (ME) as a capping agent, were coupled with a RAFT agent, S-benzyl S′ trimethoxysilylpropyltrithiocarbonate (BTPT), through a condensation reaction. Then, 2,2′-azobisisobutyronitrile (AIBN) was used to successfully initiate in situ RAFT polymerization to generate PPEGMA-g-CdTe nanocomposites. Adenosine-above-PPEGMA-grafted CdTe (Ado-i-PPEGMA-g-CdTe) hybrids were formed by the polymer shell, which had successfully undergone bioconjugation and postfunctionalization by adenosine (as a nucleoside). Fourier transform infrared (FT-IR) spectrophotometry, energy-dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy results indicated that a robust covalent bond was created between the organic PPEGMA part, cadmium telluride (CdTe) QDs, and the adenosine conjugate. The optical properties of the PPEGMA-g-CdTe and Ado-i-PPEGMA-g-CdTe hybrids were investigated by photoluminescence (PL) spectroscopy, and the results suggest that they have a great potential for application as optimal materials in biomedicine. MDPI 2019-01-06 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24748/1/Chemical%20Synthesis%20and%20Characterization%20of.pdf Trinh Duy, Nguyen and Hieu, Vu-Quang and Thanh, Sang Vo and Duy, Chinh Nguyen and Dai-Viet, N. Vo and Dai Hai, Nguyen and Kwon, Taek Lim and Dai, Lam Tran and Long, Giang Bach (2019) Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine. Polymers, 11 (1). pp. 1-12. ISSN 2073-4360 https://doi.org/10.3390/polym11010077 https://doi.org/10.3390/polym11010077
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic QD Chemistry
TP Chemical technology
spellingShingle QD Chemistry
TP Chemical technology
Trinh Duy, Nguyen
Hieu, Vu-Quang
Thanh, Sang Vo
Duy, Chinh Nguyen
Dai-Viet, N. Vo
Dai Hai, Nguyen
Kwon, Taek Lim
Dai, Lam Tran
Long, Giang Bach
Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine
description This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA-g-CdTe) quantum dots (QDs) via surface-initiated reversible addition–fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coated CdTe QDs, synthesized using 2-mercaptoethanol (ME) as a capping agent, were coupled with a RAFT agent, S-benzyl S′ trimethoxysilylpropyltrithiocarbonate (BTPT), through a condensation reaction. Then, 2,2′-azobisisobutyronitrile (AIBN) was used to successfully initiate in situ RAFT polymerization to generate PPEGMA-g-CdTe nanocomposites. Adenosine-above-PPEGMA-grafted CdTe (Ado-i-PPEGMA-g-CdTe) hybrids were formed by the polymer shell, which had successfully undergone bioconjugation and postfunctionalization by adenosine (as a nucleoside). Fourier transform infrared (FT-IR) spectrophotometry, energy-dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy results indicated that a robust covalent bond was created between the organic PPEGMA part, cadmium telluride (CdTe) QDs, and the adenosine conjugate. The optical properties of the PPEGMA-g-CdTe and Ado-i-PPEGMA-g-CdTe hybrids were investigated by photoluminescence (PL) spectroscopy, and the results suggest that they have a great potential for application as optimal materials in biomedicine.
format Article
author Trinh Duy, Nguyen
Hieu, Vu-Quang
Thanh, Sang Vo
Duy, Chinh Nguyen
Dai-Viet, N. Vo
Dai Hai, Nguyen
Kwon, Taek Lim
Dai, Lam Tran
Long, Giang Bach
author_facet Trinh Duy, Nguyen
Hieu, Vu-Quang
Thanh, Sang Vo
Duy, Chinh Nguyen
Dai-Viet, N. Vo
Dai Hai, Nguyen
Kwon, Taek Lim
Dai, Lam Tran
Long, Giang Bach
author_sort Trinh Duy, Nguyen
title Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine
title_short Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine
title_full Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine
title_fullStr Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine
title_full_unstemmed Chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted CdTe nanocrystals via RAFT polymerization for covalent immobilization of adenosine
title_sort chemical synthesis and characterization of poly(poly(ethylene glycol) methacrylate)-grafted cdte nanocrystals via raft polymerization for covalent immobilization of adenosine
publisher MDPI
publishDate 2019
url http://umpir.ump.edu.my/id/eprint/24748/
http://umpir.ump.edu.my/id/eprint/24748/
http://umpir.ump.edu.my/id/eprint/24748/
http://umpir.ump.edu.my/id/eprint/24748/1/Chemical%20Synthesis%20and%20Characterization%20of.pdf
first_indexed 2023-09-18T22:37:38Z
last_indexed 2023-09-18T22:37:38Z
_version_ 1777416702443651072

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