Biodegradable electrospun fibers for drug delivery application

The combined use of two techniques namely electrospray and spinning is made use in a highly versatile technique called electrospinning (electro+spinning). Controlled drug delivery systems have gained much attention in the last few decades. This is due to the many advantages compared with the convent...

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Main Author:	Azila Azura, Juma'at
Format:	Undergraduates Project Papers
Language:	English
Published:	2010
Subjects:	TA Engineering (General). Civil engineering (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/2483/ http://umpir.ump.edu.my/id/eprint/2483/1/CD5606_AZILA_AZURA_BT_JUMA%E2%80%99AT.pdf

id	ump-2483
recordtype	eprints
spelling	ump-24832016-04-20T07:35:43Z http://umpir.ump.edu.my/id/eprint/2483/ Biodegradable electrospun fibers for drug delivery application Azila Azura, Juma'at TA Engineering (General). Civil engineering (General) The combined use of two techniques namely electrospray and spinning is made use in a highly versatile technique called electrospinning (electro+spinning). Controlled drug delivery systems have gained much attention in the last few decades. This is due to the many advantages compared with the conventional dosage forms such as improving therapeutic efficacy and reducing toxicity by delivering them at a controlled rate to the specific site. The objective of this research is to study the drug release behavior from the electrospun scaffolds and its antimicrobial effects on microbacteria culture. Non-steroidal anti-inflammatory drug (NSAID) was embedded in two types of polymer; polylactide acid (PLLA) and polycaprolactone(PCL) with the parameters of drug concentration; 5% of indomethacin concentration and no indomethacin concentration (control), and types of microbacteria used; E.coli sp., B.cereus sp., and M.luteus sp. All the microbacterial cultures were incubated for an overnight at 37°C. Results showed throughout the study, the absorbance for polymer with no drug concentration is higher than polymer with 5% of drug concentration as there is no drugs diffuse from the polymer to inhibit the microbial growth. The growth of microbacterial can be visualized directly from the plate to assess the viability of indomethacin release. In this study, it is clear that these PLLA and PCL-with indomethacin based electrospun scaffolds hold a future potential in drug delivery system. 2010-12 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/2483/1/CD5606_AZILA_AZURA_BT_JUMA%E2%80%99AT.pdf Azila Azura, Juma'at (2010) Biodegradable electrospun fibers for drug delivery application. Faculty of Chemical & Natural Resources Engineering , Universiti Malaysia Pahang .
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TA Engineering (General). Civil engineering (General)
spellingShingle	TA Engineering (General). Civil engineering (General) Azila Azura, Juma'at Biodegradable electrospun fibers for drug delivery application
description	The combined use of two techniques namely electrospray and spinning is made use in a highly versatile technique called electrospinning (electro+spinning). Controlled drug delivery systems have gained much attention in the last few decades. This is due to the many advantages compared with the conventional dosage forms such as improving therapeutic efficacy and reducing toxicity by delivering them at a controlled rate to the specific site. The objective of this research is to study the drug release behavior from the electrospun scaffolds and its antimicrobial effects on microbacteria culture. Non-steroidal anti-inflammatory drug (NSAID) was embedded in two types of polymer; polylactide acid (PLLA) and polycaprolactone(PCL) with the parameters of drug concentration; 5% of indomethacin concentration and no indomethacin concentration (control), and types of microbacteria used; E.coli sp., B.cereus sp., and M.luteus sp. All the microbacterial cultures were incubated for an overnight at 37°C. Results showed throughout the study, the absorbance for polymer with no drug concentration is higher than polymer with 5% of drug concentration as there is no drugs diffuse from the polymer to inhibit the microbial growth. The growth of microbacterial can be visualized directly from the plate to assess the viability of indomethacin release. In this study, it is clear that these PLLA and PCL-with indomethacin based electrospun scaffolds hold a future potential in drug delivery system.
format	Undergraduates Project Papers
author	Azila Azura, Juma'at
author_facet	Azila Azura, Juma'at
author_sort	Azila Azura, Juma'at
title	Biodegradable electrospun fibers for drug delivery application
title_short	Biodegradable electrospun fibers for drug delivery application
title_full	Biodegradable electrospun fibers for drug delivery application
title_fullStr	Biodegradable electrospun fibers for drug delivery application
title_full_unstemmed	Biodegradable electrospun fibers for drug delivery application
title_sort	biodegradable electrospun fibers for drug delivery application
publishDate	2010
url	http://umpir.ump.edu.my/id/eprint/2483/ http://umpir.ump.edu.my/id/eprint/2483/1/CD5606_AZILA_AZURA_BT_JUMA%E2%80%99AT.pdf
first_indexed	2023-09-18T21:56:19Z
last_indexed	2023-09-18T21:56:19Z
_version_	1777414103336222720

Biodegradable electrospun fibers for drug delivery application

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