Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent

In the present study, high-methoxyl pectin (HMP) was extracted from Hylocereus polyrhizus peel's using physico-chemical process. In addition, the hypolipidemic activity of HMP was investigated at different concentration and time corresponding to its adsorption ability. FTIR and contact angle an...

Full description

Bibliographic Details
Main Authors:	Rubaiyi, M. Zaid, Mishra, Puranjan, Zularisam, A. W., Mimi Sakinah, A. M.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2019
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/24883/ http://umpir.ump.edu.my/id/eprint/24883/ http://umpir.ump.edu.my/id/eprint/24883/ http://umpir.ump.edu.my/id/eprint/24883/1/Hylocereus%20polyrhizus%20peel%E2%80%99s%20high-methoxyl1.pdf

id	ump-24883
recordtype	eprints
spelling	ump-248832019-05-08T04:41:18Z http://umpir.ump.edu.my/id/eprint/24883/ Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent Rubaiyi, M. Zaid Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M. TP Chemical technology In the present study, high-methoxyl pectin (HMP) was extracted from Hylocereus polyrhizus peel's using physico-chemical process. In addition, the hypolipidemic activity of HMP was investigated at different concentration and time corresponding to its adsorption ability. FTIR and contact angle analysis were used to determine the sorbent characterization. A high degree of esterification (63.8%) and the contact angle (95.5°) confirmed hydrophobic nature and resulting bad wetting of the HMP extract, respectively. The methoxyl content in the pectin acted as an affinity-precursor of the pectin towards cholesterol due to its increased hydrophobicity. The maximum equilibrium uptake capacity of cholesterol of 370.5 mg/g (0.96 mmol/g) was observed by HMP. The experimental data showed good fitting for Freundlich isotherm equation and followed pseudo-first-order kinetic model with a correlation coefficient (R2) of 0.89–0.97 due to physisorption mechanism. Intra-particle model confirmed that the cholesterol sorption rate by HMP was significantly influenced by external mass transfer (surface diffusion) and intra-particle diffusion (diffusion control). It was also revealed that the HMP extracted from Hylocereus polyrhizus peels possess a high affinity towards cholesterol, making it an ideal hypolipidemic agent. Elsevier Ltd 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24883/1/Hylocereus%20polyrhizus%20peel%E2%80%99s%20high-methoxyl1.pdf Rubaiyi, M. Zaid and Mishra, Puranjan and Zularisam, A. W. and Mimi Sakinah, A. M. (2019) Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent. International Journal of Biological Macromolecules. pp. 1-29. ISSN 0141-8130 (In Press) https://doi.org/10.1016/j.ijbiomac.2019.03.143 https://doi.org/10.1016/j.ijbiomac.2019.03.143
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Rubaiyi, M. Zaid Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M. Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent
description	In the present study, high-methoxyl pectin (HMP) was extracted from Hylocereus polyrhizus peel's using physico-chemical process. In addition, the hypolipidemic activity of HMP was investigated at different concentration and time corresponding to its adsorption ability. FTIR and contact angle analysis were used to determine the sorbent characterization. A high degree of esterification (63.8%) and the contact angle (95.5°) confirmed hydrophobic nature and resulting bad wetting of the HMP extract, respectively. The methoxyl content in the pectin acted as an affinity-precursor of the pectin towards cholesterol due to its increased hydrophobicity. The maximum equilibrium uptake capacity of cholesterol of 370.5 mg/g (0.96 mmol/g) was observed by HMP. The experimental data showed good fitting for Freundlich isotherm equation and followed pseudo-first-order kinetic model with a correlation coefficient (R2) of 0.89–0.97 due to physisorption mechanism. Intra-particle model confirmed that the cholesterol sorption rate by HMP was significantly influenced by external mass transfer (surface diffusion) and intra-particle diffusion (diffusion control). It was also revealed that the HMP extracted from Hylocereus polyrhizus peels possess a high affinity towards cholesterol, making it an ideal hypolipidemic agent.
format	Article
author	Rubaiyi, M. Zaid Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M.
author_facet	Rubaiyi, M. Zaid Mishra, Puranjan Zularisam, A. W. Mimi Sakinah, A. M.
author_sort	Rubaiyi, M. Zaid
title	Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent
title_short	Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent
title_full	Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent
title_fullStr	Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent
title_full_unstemmed	Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent
title_sort	hylocereus polyrhizus peel's high-methoxyl pectin: a potential source of hypolipidemic agent
publisher	Elsevier Ltd
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/24883/ http://umpir.ump.edu.my/id/eprint/24883/ http://umpir.ump.edu.my/id/eprint/24883/ http://umpir.ump.edu.my/id/eprint/24883/1/Hylocereus%20polyrhizus%20peel%E2%80%99s%20high-methoxyl1.pdf
first_indexed	2023-09-18T22:37:54Z
last_indexed	2023-09-18T22:37:54Z
_version_	1777416718909440000

Hylocereus polyrhizus peel's high-methoxyl pectin: A potential source of hypolipidemic agent

Similar Items