Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid

Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid

The natural polymer chitosan is widely used for medical and drug delivery applications. Low molecular weight chitosan (LMWC) has superior properties compared to high molecular weight chitosan (HMWC), which open new applications of LMWC, especially in the cosmetics, food, and pharmaceutical industrie...

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Main Authors: Aljbour, Nawzat D., Beg, M. D. H., Jolius, Gimbun
Format: Article
Language:English
Published: Wiley 2019
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/24987/
http://umpir.ump.edu.my/id/eprint/24987/
http://umpir.ump.edu.my/id/eprint/24987/
http://umpir.ump.edu.my/id/eprint/24987/1/Acid%20Hydrolysis%20of%20Chitosan%20to%20Oligomers%20Using%20Hydrochloric%20Acid1.pdf
id ump-24987
recordtype eprints
spelling ump-249872019-05-21T03:20:47Z http://umpir.ump.edu.my/id/eprint/24987/ Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid Aljbour, Nawzat D. Beg, M. D. H. Jolius, Gimbun TP Chemical technology The natural polymer chitosan is widely used for medical and drug delivery applications. Low molecular weight chitosan (LMWC) has superior properties compared to high molecular weight chitosan (HMWC), which open new applications of LMWC, especially in the cosmetics, food, and pharmaceutical industries. LMWC is often produced from HMWC by acid, enzymatic, or oxidative hydrolysis. Industrially, hydrolysis with dilute HCl is preferred, since it is simple, practical, and gives a high yield. In this study 2M HCl was used to prepare LMWC. A high average depolymerization yield of 87% was obtained. The LMWCs were characterized by FTIR spectroscopy, and the molecular weight and degree of deacetylation were determined. The prepared LMWCs are fully deacetylated, and their production by this method is reproducible. Wiley 2019 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/24987/1/Acid%20Hydrolysis%20of%20Chitosan%20to%20Oligomers%20Using%20Hydrochloric%20Acid1.pdf Aljbour, Nawzat D. and Beg, M. D. H. and Jolius, Gimbun (2019) Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid. Chemical Engineering and Technology. ISSN 1521-4125 (In Press) https://doi.org/10.1002/ceat.201800527 https://doi.org/10.1002/ceat.201800527
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Aljbour, Nawzat D.
Beg, M. D. H.
Jolius, Gimbun
Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid
description The natural polymer chitosan is widely used for medical and drug delivery applications. Low molecular weight chitosan (LMWC) has superior properties compared to high molecular weight chitosan (HMWC), which open new applications of LMWC, especially in the cosmetics, food, and pharmaceutical industries. LMWC is often produced from HMWC by acid, enzymatic, or oxidative hydrolysis. Industrially, hydrolysis with dilute HCl is preferred, since it is simple, practical, and gives a high yield. In this study 2M HCl was used to prepare LMWC. A high average depolymerization yield of 87% was obtained. The LMWCs were characterized by FTIR spectroscopy, and the molecular weight and degree of deacetylation were determined. The prepared LMWCs are fully deacetylated, and their production by this method is reproducible.
format Article
author Aljbour, Nawzat D.
Beg, M. D. H.
Jolius, Gimbun
author_facet Aljbour, Nawzat D.
Beg, M. D. H.
Jolius, Gimbun
author_sort Aljbour, Nawzat D.
title Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid
title_short Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid
title_full Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid
title_fullStr Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid
title_full_unstemmed Acid Hydrolysis of Chitosan to Oligomers Using Hydrochloric Acid
title_sort acid hydrolysis of chitosan to oligomers using hydrochloric acid
publisher Wiley
publishDate 2019
url http://umpir.ump.edu.my/id/eprint/24987/
http://umpir.ump.edu.my/id/eprint/24987/
http://umpir.ump.edu.my/id/eprint/24987/
http://umpir.ump.edu.my/id/eprint/24987/1/Acid%20Hydrolysis%20of%20Chitosan%20to%20Oligomers%20Using%20Hydrochloric%20Acid1.pdf
first_indexed 2023-09-18T22:38:07Z
last_indexed 2023-09-18T22:38:07Z
_version_ 1777416733132324864

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