Combined minimum-run resolution IV and central composite design for optimized removal of the tetracycline drug over metal–organic framework-templated porous carbon

In this study, a minimum-run resolution IV and central composite design have been developed to optimize tetracycline removal efficiency over mesoporous carbon derived from the metal-organic framework MIL-53 (Fe) as a self-sacrificial template. Firstly, minimum-run resolution IV, powered by the Desig...

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Main Authors:	Van Tran, Thuan, Nguyen, Duyen Thi Cam, Le, Hanh T. N., Bach, Long Giang, Vo, Dai-Viet N., Lim, Kwon Taek, Nguyen, Trinh Duy
Format:	Article
Language:	English
Published:	MDPI 2019
Subjects:	QD Chemistry TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/25148/ http://umpir.ump.edu.my/id/eprint/25148/ http://umpir.ump.edu.my/id/eprint/25148/ http://umpir.ump.edu.my/id/eprint/25148/1/Combined%20minimum-run%20resolution%20IV%20and%20central%20composite%20design.pdf

id	ump-25148
recordtype	eprints
spelling	ump-251482019-10-24T08:04:29Z http://umpir.ump.edu.my/id/eprint/25148/ Combined minimum-run resolution IV and central composite design for optimized removal of the tetracycline drug over metal–organic framework-templated porous carbon Van Tran, Thuan Nguyen, Duyen Thi Cam Le, Hanh T. N. Bach, Long Giang Vo, Dai-Viet N. Lim, Kwon Taek Nguyen, Trinh Duy QD Chemistry TP Chemical technology In this study, a minimum-run resolution IV and central composite design have been developed to optimize tetracycline removal efficiency over mesoporous carbon derived from the metal-organic framework MIL-53 (Fe) as a self-sacrificial template. Firstly, minimum-run resolution IV, powered by the Design–Expert program, was used as an efficient and reliable screening study for investigating a set of seven factors, these were: tetracycline concentration (A: 5–15 mg/g), dose of mesoporous carbons (MPC) (B: 0.05–0.15 g/L), initial pH level (C: 2–10), contact time (D: 1–3 h), temperature (E: 20–40 °C), shaking speed (F: 150–250 rpm), and Na+ ionic strength (G: 10–90 mM) at both low (−1) and high (+1) levels, for investigation of the data ranges. The 20-trial model was analyzed and assessed by Analysis of Variance (ANOVA) data, and diagnostic plots (e.g., the Pareto chart, and half-normal and normal probability plots). Based on minimum-run resolution IV, three factors, including tetracycline concentration (A), dose of MPC (B), and initial pH (C), were selected to carry out the optimization study using a central composite design. The proposed quadratic model was found to be statistically significant at the 95% confidence level due to a low P-value (<0.05), high R2 (0.9078), and the AP ratio (11.4), along with an abundance of diagnostic plots (3D response surfaces, Cook’s distance, Box-Cox, DFFITS, Leverage versus run, residuals versus runs, and actual versus predicted). Under response surface methodology-optimized conditions (e.g., tetracycline concentration of 1.9 mg/g, MPC dose of 0.15 g/L, and pH level of 3.9), the highest tetracycline removal efficiency via confirmation tests reached up to 98.0%–99.7%. Also, kinetic intraparticle diffusion and isotherm models were systematically studied to interpret how tetracycline molecules were absorbed on an MPC structure. In particular, the adsorption mechanisms including “electrostatic attraction” and “π–π interaction” were proposed. MDPI 2019-05-16 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/25148/1/Combined%20minimum-run%20resolution%20IV%20and%20central%20composite%20design.pdf Van Tran, Thuan and Nguyen, Duyen Thi Cam and Le, Hanh T. N. and Bach, Long Giang and Vo, Dai-Viet N. and Lim, Kwon Taek and Nguyen, Trinh Duy (2019) Combined minimum-run resolution IV and central composite design for optimized removal of the tetracycline drug over metal–organic framework-templated porous carbon. Molecules, 24 (10). pp. 1-21. ISSN 1420-3049 (print); 1420-3049 (online) https://doi.org/10.3390/molecules24101887 https://doi.org/10.3390/molecules24101887
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry TP Chemical technology
spellingShingle	QD Chemistry TP Chemical technology Van Tran, Thuan Nguyen, Duyen Thi Cam Le, Hanh T. N. Bach, Long Giang Vo, Dai-Viet N. Lim, Kwon Taek Nguyen, Trinh Duy Combined minimum-run resolution IV and central composite design for optimized removal of the tetracycline drug over metal–organic framework-templated porous carbon
description	In this study, a minimum-run resolution IV and central composite design have been developed to optimize tetracycline removal efficiency over mesoporous carbon derived from the metal-organic framework MIL-53 (Fe) as a self-sacrificial template. Firstly, minimum-run resolution IV, powered by the Design–Expert program, was used as an efficient and reliable screening study for investigating a set of seven factors, these were: tetracycline concentration (A: 5–15 mg/g), dose of mesoporous carbons (MPC) (B: 0.05–0.15 g/L), initial pH level (C: 2–10), contact time (D: 1–3 h), temperature (E: 20–40 °C), shaking speed (F: 150–250 rpm), and Na+ ionic strength (G: 10–90 mM) at both low (−1) and high (+1) levels, for investigation of the data ranges. The 20-trial model was analyzed and assessed by Analysis of Variance (ANOVA) data, and diagnostic plots (e.g., the Pareto chart, and half-normal and normal probability plots). Based on minimum-run resolution IV, three factors, including tetracycline concentration (A), dose of MPC (B), and initial pH (C), were selected to carry out the optimization study using a central composite design. The proposed quadratic model was found to be statistically significant at the 95% confidence level due to a low P-value (<0.05), high R2 (0.9078), and the AP ratio (11.4), along with an abundance of diagnostic plots (3D response surfaces, Cook’s distance, Box-Cox, DFFITS, Leverage versus run, residuals versus runs, and actual versus predicted). Under response surface methodology-optimized conditions (e.g., tetracycline concentration of 1.9 mg/g, MPC dose of 0.15 g/L, and pH level of 3.9), the highest tetracycline removal efficiency via confirmation tests reached up to 98.0%–99.7%. Also, kinetic intraparticle diffusion and isotherm models were systematically studied to interpret how tetracycline molecules were absorbed on an MPC structure. In particular, the adsorption mechanisms including “electrostatic attraction” and “π–π interaction” were proposed.
format	Article
author	Van Tran, Thuan Nguyen, Duyen Thi Cam Le, Hanh T. N. Bach, Long Giang Vo, Dai-Viet N. Lim, Kwon Taek Nguyen, Trinh Duy
author_facet	Van Tran, Thuan Nguyen, Duyen Thi Cam Le, Hanh T. N. Bach, Long Giang Vo, Dai-Viet N. Lim, Kwon Taek Nguyen, Trinh Duy
author_sort	Van Tran, Thuan
title	Combined minimum-run resolution IV and central composite design for optimized removal of the tetracycline drug over metal–organic framework-templated porous carbon
title_short	Combined minimum-run resolution IV and central composite design for optimized removal of the tetracycline drug over metal–organic framework-templated porous carbon
title_full	Combined minimum-run resolution IV and central composite design for optimized removal of the tetracycline drug over metal–organic framework-templated porous carbon
title_fullStr	Combined minimum-run resolution IV and central composite design for optimized removal of the tetracycline drug over metal–organic framework-templated porous carbon
title_full_unstemmed	Combined minimum-run resolution IV and central composite design for optimized removal of the tetracycline drug over metal–organic framework-templated porous carbon
title_sort	combined minimum-run resolution iv and central composite design for optimized removal of the tetracycline drug over metal–organic framework-templated porous carbon
publisher	MDPI
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/25148/ http://umpir.ump.edu.my/id/eprint/25148/ http://umpir.ump.edu.my/id/eprint/25148/ http://umpir.ump.edu.my/id/eprint/25148/1/Combined%20minimum-run%20resolution%20IV%20and%20central%20composite%20design.pdf
first_indexed	2023-09-18T22:38:28Z
last_indexed	2023-09-18T22:38:28Z
_version_	1777416754451972096

Combined minimum-run resolution IV and central composite design for optimized removal of the tetracycline drug over metal–organic framework-templated porous carbon

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