Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery

Graphene oxide (GO) possesses excellent mechanical strength, biocompatibility, colloidal stability, large surface area and high adsorption capability. It has driven to cancer nanotechnology to defeat cancer therapy obstacles, via integration into three-dimensional (3D) hydrogel network with biocompa...

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Main Authors:	Ghawanmeh, Abdullah A., Ali, Gomaa A. M., Algarni, H., Sarkar, Shaheen M., K. F., Chong
Format:	Article
Language:	English
Published:	Springer 2019
Subjects:	QD Chemistry RS Pharmacy and materia medica TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/25322/ http://umpir.ump.edu.my/id/eprint/25322/ http://umpir.ump.edu.my/id/eprint/25322/ http://umpir.ump.edu.my/id/eprint/25322/1/Graphene%20oxide-based%20hydrogels%20as%20a%20nanocarrier%20for%20anticancer%20.pdf

id	ump-25322
recordtype	eprints
spelling	ump-253222019-10-07T07:08:59Z http://umpir.ump.edu.my/id/eprint/25322/ Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery Ghawanmeh, Abdullah A. Ali, Gomaa A. M. Algarni, H. Sarkar, Shaheen M. K. F., Chong QD Chemistry RS Pharmacy and materia medica TP Chemical technology Graphene oxide (GO) possesses excellent mechanical strength, biocompatibility, colloidal stability, large surface area and high adsorption capability. It has driven to cancer nanotechnology to defeat cancer therapy obstacles, via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier, and controllable release of anticancer drugs. Specifically, the surface of GO affords π-π stacking and hydrophilic interactions with anticancer drugs. Additionally, modification of GO with various polymers such as natural and synthetic polymers enhances its biodegradability, drug loading, and target delivery. In this review, GO based hydrogels research accomplishments are reviewed on the aspects of crosslinking strategies, preparation methods, the model drug, polymer conjugation and modification with targeting ligands. Moreover, swelling kinetics, drug release profile and biological activity in vivoand in vitro are discussed. The biocompatibility of GO based hydrogels is also discussed from the perspective of its nano-bio interfaces. Apart from that, the clinical potential of GO based hydrogels and its major challenges are addressed in detail. Finally, this review concludes with a summary and invigorating future perspectives of GO based hydrogels for anticancer drug delivery. It is anticipated that this review can stimulate a new research gateway to facilitate the development of anticancer drug delivery by harnessing the unique properties of GO based hydrogels, such as large surface area, chemical purity, high loading capacity of drug, chemical stability, and the nature of lipophilic for cell membrane penetration. Springer 2019-05 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/25322/1/Graphene%20oxide-based%20hydrogels%20as%20a%20nanocarrier%20for%20anticancer%20.pdf Ghawanmeh, Abdullah A. and Ali, Gomaa A. M. and Algarni, H. and Sarkar, Shaheen M. and K. F., Chong (2019) Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery. Nano Research, 12 (5). pp. 973-990. ISSN 1998-0124 (Print), 1998-0000 (Online) https://doi.org/10.1007/s12274-019-2300-4 https://doi.org/10.1007/s12274-019-2300-4
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry RS Pharmacy and materia medica TP Chemical technology
spellingShingle	QD Chemistry RS Pharmacy and materia medica TP Chemical technology Ghawanmeh, Abdullah A. Ali, Gomaa A. M. Algarni, H. Sarkar, Shaheen M. K. F., Chong Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery
description	Graphene oxide (GO) possesses excellent mechanical strength, biocompatibility, colloidal stability, large surface area and high adsorption capability. It has driven to cancer nanotechnology to defeat cancer therapy obstacles, via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier, and controllable release of anticancer drugs. Specifically, the surface of GO affords π-π stacking and hydrophilic interactions with anticancer drugs. Additionally, modification of GO with various polymers such as natural and synthetic polymers enhances its biodegradability, drug loading, and target delivery. In this review, GO based hydrogels research accomplishments are reviewed on the aspects of crosslinking strategies, preparation methods, the model drug, polymer conjugation and modification with targeting ligands. Moreover, swelling kinetics, drug release profile and biological activity in vivoand in vitro are discussed. The biocompatibility of GO based hydrogels is also discussed from the perspective of its nano-bio interfaces. Apart from that, the clinical potential of GO based hydrogels and its major challenges are addressed in detail. Finally, this review concludes with a summary and invigorating future perspectives of GO based hydrogels for anticancer drug delivery. It is anticipated that this review can stimulate a new research gateway to facilitate the development of anticancer drug delivery by harnessing the unique properties of GO based hydrogels, such as large surface area, chemical purity, high loading capacity of drug, chemical stability, and the nature of lipophilic for cell membrane penetration.
format	Article
author	Ghawanmeh, Abdullah A. Ali, Gomaa A. M. Algarni, H. Sarkar, Shaheen M. K. F., Chong
author_facet	Ghawanmeh, Abdullah A. Ali, Gomaa A. M. Algarni, H. Sarkar, Shaheen M. K. F., Chong
author_sort	Ghawanmeh, Abdullah A.
title	Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery
title_short	Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery
title_full	Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery
title_fullStr	Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery
title_full_unstemmed	Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery
title_sort	graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery
publisher	Springer
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/25322/ http://umpir.ump.edu.my/id/eprint/25322/ http://umpir.ump.edu.my/id/eprint/25322/ http://umpir.ump.edu.my/id/eprint/25322/1/Graphene%20oxide-based%20hydrogels%20as%20a%20nanocarrier%20for%20anticancer%20.pdf
first_indexed	2023-09-18T22:38:50Z
last_indexed	2023-09-18T22:38:50Z
_version_	1777416777294151680

Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery

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