Pharmacological properties of centella asiatica hydrogel in accelerating wound healing in rabbits

Background: Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attempt to develop a formulation with accelerated wound healing effect, the prese...

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Main Authors:	Afnan, Sh. Ahmed, Muhammad, Taher, Mandal, Uttam K., Juliana, Md Jaffri, Deny, Susanti, Mahmood, Syed, Zainul Amiruddin, Zakaria
Format:	Article
Language:	English
Published:	BioMed Central Ltd. 2019
Subjects:	RD Surgery TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/25850/ http://umpir.ump.edu.my/id/eprint/25850/ http://umpir.ump.edu.my/id/eprint/25850/ http://umpir.ump.edu.my/id/eprint/25850/1/Pharmacological%20properties%20of%20Centella%20asiatica%20hydrogel%20in%20accelerating.pdf

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recordtype	eprints
spelling	ump-258502019-10-03T08:03:43Z http://umpir.ump.edu.my/id/eprint/25850/ Pharmacological properties of centella asiatica hydrogel in accelerating wound healing in rabbits Afnan, Sh. Ahmed Muhammad, Taher Mandal, Uttam K. Juliana, Md Jaffri Deny, Susanti Mahmood, Syed Zainul Amiruddin, Zakaria RD Surgery TP Chemical technology Background: Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attempt to develop a formulation with accelerated wound healing effect, the present study was performed to examine in vivo efficacy of asiaticoside-rich hydrogel formulation in rabbits. Methods: Asiaticoside-rich fraction was prepared from C. asiatica aerial part and then incorporated into polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogel. The hydrogel was subjected to wound healing investigation using the in vivo incision model. Results: The results obtained demonstrated that: i) the hydrogel formulation did not cause any signs of irritation on the rabbits’ skin and; ii) enhanced wound healing 15% faster than the commercial cream and > 40% faster than the untreated wounds. The skin healing process was seen in all wounds marked by formation of a thick epithelial layer, keratin, and moderate formation of granulation tissues, fibroblasts and collagen with no fibrinoid necrosis detected. Conclusion: The asiaticoside-rich hydrogel developed using the freeze-thaw method was effective in accelerating wound healing in rabbits. BioMed Central Ltd. 2019-08-14 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/25850/1/Pharmacological%20properties%20of%20Centella%20asiatica%20hydrogel%20in%20accelerating.pdf Afnan, Sh. Ahmed and Muhammad, Taher and Mandal, Uttam K. and Juliana, Md Jaffri and Deny, Susanti and Mahmood, Syed and Zainul Amiruddin, Zakaria (2019) Pharmacological properties of centella asiatica hydrogel in accelerating wound healing in rabbits. BMC Complementary and Alternative Medicine, 19 (1). pp. 1-7. ISSN 1472-6882 https://doi.org/10.1186/s12906-019-2625-2 https://doi.org/10.1186/s12906-019-2625-2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	RD Surgery TP Chemical technology
spellingShingle	RD Surgery TP Chemical technology Afnan, Sh. Ahmed Muhammad, Taher Mandal, Uttam K. Juliana, Md Jaffri Deny, Susanti Mahmood, Syed Zainul Amiruddin, Zakaria Pharmacological properties of centella asiatica hydrogel in accelerating wound healing in rabbits
description	Background: Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attempt to develop a formulation with accelerated wound healing effect, the present study was performed to examine in vivo efficacy of asiaticoside-rich hydrogel formulation in rabbits. Methods: Asiaticoside-rich fraction was prepared from C. asiatica aerial part and then incorporated into polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogel. The hydrogel was subjected to wound healing investigation using the in vivo incision model. Results: The results obtained demonstrated that: i) the hydrogel formulation did not cause any signs of irritation on the rabbits’ skin and; ii) enhanced wound healing 15% faster than the commercial cream and > 40% faster than the untreated wounds. The skin healing process was seen in all wounds marked by formation of a thick epithelial layer, keratin, and moderate formation of granulation tissues, fibroblasts and collagen with no fibrinoid necrosis detected. Conclusion: The asiaticoside-rich hydrogel developed using the freeze-thaw method was effective in accelerating wound healing in rabbits.
format	Article
author	Afnan, Sh. Ahmed Muhammad, Taher Mandal, Uttam K. Juliana, Md Jaffri Deny, Susanti Mahmood, Syed Zainul Amiruddin, Zakaria
author_facet	Afnan, Sh. Ahmed Muhammad, Taher Mandal, Uttam K. Juliana, Md Jaffri Deny, Susanti Mahmood, Syed Zainul Amiruddin, Zakaria
author_sort	Afnan, Sh. Ahmed
title	Pharmacological properties of centella asiatica hydrogel in accelerating wound healing in rabbits
title_short	Pharmacological properties of centella asiatica hydrogel in accelerating wound healing in rabbits
title_full	Pharmacological properties of centella asiatica hydrogel in accelerating wound healing in rabbits
title_fullStr	Pharmacological properties of centella asiatica hydrogel in accelerating wound healing in rabbits
title_full_unstemmed	Pharmacological properties of centella asiatica hydrogel in accelerating wound healing in rabbits
title_sort	pharmacological properties of centella asiatica hydrogel in accelerating wound healing in rabbits
publisher	BioMed Central Ltd.
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/25850/ http://umpir.ump.edu.my/id/eprint/25850/ http://umpir.ump.edu.my/id/eprint/25850/ http://umpir.ump.edu.my/id/eprint/25850/1/Pharmacological%20properties%20of%20Centella%20asiatica%20hydrogel%20in%20accelerating.pdf
first_indexed	2023-09-18T22:39:55Z
last_indexed	2023-09-18T22:39:55Z
_version_	1777416845797621760

Pharmacological properties of centella asiatica hydrogel in accelerating wound healing in rabbits

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