Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods...

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Main Authors: Poh, Yen Khor, Mohd F. F., Mohd Aluwi, Kamal, Rullah, Kok, Wai Lam
Format: Article
Language:English
Published: Elsevier 2019
Subjects:
Online Access:http://umpir.ump.edu.my/id/eprint/26063/
http://umpir.ump.edu.my/id/eprint/26063/
http://umpir.ump.edu.my/id/eprint/26063/
http://umpir.ump.edu.my/id/eprint/26063/1/Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin%20derivatives%20.pdf
id ump-26063
recordtype eprints
spelling ump-260632019-11-27T02:32:42Z http://umpir.ump.edu.my/id/eprint/26063/ Insights on the synthesis of asymmetric curcumin derivatives and their biological activities Poh, Yen Khor Mohd F. F., Mohd Aluwi Kamal, Rullah Kok, Wai Lam QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica TP Chemical technology Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine. Elsevier 2019-12-01 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26063/1/Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin%20derivatives%20.pdf Poh, Yen Khor and Mohd F. F., Mohd Aluwi and Kamal, Rullah and Kok, Wai Lam (2019) Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. European Journal of Medicinal Chemistry, 183. ISSN 0223-5234 https://doi.org/10.1016/j.ejmech.2019.111704 https://doi.org/10.1016/j.ejmech.2019.111704
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic QD Chemistry
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
TP Chemical technology
spellingShingle QD Chemistry
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
TP Chemical technology
Poh, Yen Khor
Mohd F. F., Mohd Aluwi
Kamal, Rullah
Kok, Wai Lam
Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
description Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine.
format Article
author Poh, Yen Khor
Mohd F. F., Mohd Aluwi
Kamal, Rullah
Kok, Wai Lam
author_facet Poh, Yen Khor
Mohd F. F., Mohd Aluwi
Kamal, Rullah
Kok, Wai Lam
author_sort Poh, Yen Khor
title Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_short Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_full Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_fullStr Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_full_unstemmed Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_sort insights on the synthesis of asymmetric curcumin derivatives and their biological activities
publisher Elsevier
publishDate 2019
url http://umpir.ump.edu.my/id/eprint/26063/
http://umpir.ump.edu.my/id/eprint/26063/
http://umpir.ump.edu.my/id/eprint/26063/
http://umpir.ump.edu.my/id/eprint/26063/1/Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin%20derivatives%20.pdf
first_indexed 2023-09-18T22:40:21Z
last_indexed 2023-09-18T22:40:21Z
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