Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods...

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Main Authors:	Poh, Yen Khor, Mohd F. F., Mohd Aluwi, Kamal, Rullah, Kok, Wai Lam
Format:	Article
Language:	English
Published:	Elsevier 2019
Subjects:	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/26063/ http://umpir.ump.edu.my/id/eprint/26063/ http://umpir.ump.edu.my/id/eprint/26063/ http://umpir.ump.edu.my/id/eprint/26063/1/Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin%20derivatives%20.pdf

id	ump-26063
recordtype	eprints
spelling	ump-260632019-11-27T02:32:42Z http://umpir.ump.edu.my/id/eprint/26063/ Insights on the synthesis of asymmetric curcumin derivatives and their biological activities Poh, Yen Khor Mohd F. F., Mohd Aluwi Kamal, Rullah Kok, Wai Lam QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica TP Chemical technology Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine. Elsevier 2019-12-01 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26063/1/Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin%20derivatives%20.pdf Poh, Yen Khor and Mohd F. F., Mohd Aluwi and Kamal, Rullah and Kok, Wai Lam (2019) Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. European Journal of Medicinal Chemistry, 183. ISSN 0223-5234 https://doi.org/10.1016/j.ejmech.2019.111704 https://doi.org/10.1016/j.ejmech.2019.111704
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica TP Chemical technology
spellingShingle	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica TP Chemical technology Poh, Yen Khor Mohd F. F., Mohd Aluwi Kamal, Rullah Kok, Wai Lam Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
description	Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine.
format	Article
author	Poh, Yen Khor Mohd F. F., Mohd Aluwi Kamal, Rullah Kok, Wai Lam
author_facet	Poh, Yen Khor Mohd F. F., Mohd Aluwi Kamal, Rullah Kok, Wai Lam
author_sort	Poh, Yen Khor
title	Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_short	Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_full	Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_fullStr	Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_full_unstemmed	Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
title_sort	insights on the synthesis of asymmetric curcumin derivatives and their biological activities
publisher	Elsevier
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/26063/ http://umpir.ump.edu.my/id/eprint/26063/ http://umpir.ump.edu.my/id/eprint/26063/ http://umpir.ump.edu.my/id/eprint/26063/1/Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin%20derivatives%20.pdf
first_indexed	2023-09-18T22:40:21Z
last_indexed	2023-09-18T22:40:21Z
_version_	1777416873232564224

Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

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