Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship

(−)-Colchicine, an anti-microtubulin polymerization agent, is a valuable medication and the drug of choice for gout, Behçet’s disease and familial Mediterranean fever. It has a narrow therapeutic index due to its high toxicity towards normal cells. Nonetheless, numerous (−)-colchicine derivatives ha...

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Main Authors:	Ghawanmeh, Abdullah A., Al-Bajalan, Hussein M., Mackeen, Mukram Mohamed, Alali, Feras Q., K. F., Chong
Format:	Article
Language:	English
Published:	Elsevier 2019
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/26482/ http://umpir.ump.edu.my/id/eprint/26482/ http://umpir.ump.edu.my/id/eprint/26482/ http://umpir.ump.edu.my/id/eprint/26482/1/Recent%20developments%20on%20%28%E2%88%92%29-colchicine%20derivatives%20_%20synthesis%20and%20structure.pdf

id	ump-26482
recordtype	eprints
spelling	ump-264822019-12-06T04:07:27Z http://umpir.ump.edu.my/id/eprint/26482/ Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship Ghawanmeh, Abdullah A. Al-Bajalan, Hussein M. Mackeen, Mukram Mohamed Alali, Feras Q. K. F., Chong TP Chemical technology (−)-Colchicine, an anti-microtubulin polymerization agent, is a valuable medication and the drug of choice for gout, Behçet’s disease and familial Mediterranean fever. It has a narrow therapeutic index due to its high toxicity towards normal cells. Nonetheless, numerous (−)-colchicine derivatives have been synthesized and studied for their structure-activity relationship and preferential toxicity. Different functional groups such as amides, thioamides, N-arylurea and 8,12-diene cyclic have been incorporated into (−)-colchicine, resulting in derivatives (with moieties) that include electron-withdrawing and electron-donating groups. This review article focuses on recent developments in the chemical synthesis of (−)-colchicine derivatives, the substituents used, the functional groups linked to the substituents, the moieties and biological studies. Moreover, the current classification of derivatives based on the (−)-colchicine rings, namely ring A, B, and C (−)-colchicine derivatives, is discussed. This work demonstrates and summarizes the significance of (−)-colchicine derivatives in the biological field, and discusses their promising therapeutics for the future. Elsevier 2019-10-18 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26482/1/Recent%20developments%20on%20%28%E2%88%92%29-colchicine%20derivatives%20_%20synthesis%20and%20structure.pdf Ghawanmeh, Abdullah A. and Al-Bajalan, Hussein M. and Mackeen, Mukram Mohamed and Alali, Feras Q. and K. F., Chong (2019) Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship. European Journal of Medicinal Chemistry, 185 (111788). pp. 1-16. ISSN 0223-5234 https://doi.org/10.1016/j.ejmech.2019.111788 https://doi.org/10.1016/j.ejmech.2019.111788
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Ghawanmeh, Abdullah A. Al-Bajalan, Hussein M. Mackeen, Mukram Mohamed Alali, Feras Q. K. F., Chong Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship
description	(−)-Colchicine, an anti-microtubulin polymerization agent, is a valuable medication and the drug of choice for gout, Behçet’s disease and familial Mediterranean fever. It has a narrow therapeutic index due to its high toxicity towards normal cells. Nonetheless, numerous (−)-colchicine derivatives have been synthesized and studied for their structure-activity relationship and preferential toxicity. Different functional groups such as amides, thioamides, N-arylurea and 8,12-diene cyclic have been incorporated into (−)-colchicine, resulting in derivatives (with moieties) that include electron-withdrawing and electron-donating groups. This review article focuses on recent developments in the chemical synthesis of (−)-colchicine derivatives, the substituents used, the functional groups linked to the substituents, the moieties and biological studies. Moreover, the current classification of derivatives based on the (−)-colchicine rings, namely ring A, B, and C (−)-colchicine derivatives, is discussed. This work demonstrates and summarizes the significance of (−)-colchicine derivatives in the biological field, and discusses their promising therapeutics for the future.
format	Article
author	Ghawanmeh, Abdullah A. Al-Bajalan, Hussein M. Mackeen, Mukram Mohamed Alali, Feras Q. K. F., Chong
author_facet	Ghawanmeh, Abdullah A. Al-Bajalan, Hussein M. Mackeen, Mukram Mohamed Alali, Feras Q. K. F., Chong
author_sort	Ghawanmeh, Abdullah A.
title	Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship
title_short	Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship
title_full	Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship
title_fullStr	Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship
title_full_unstemmed	Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship
title_sort	recent developments on (−)-colchicine derivatives: synthesis and structure-activity relationship
publisher	Elsevier
publishDate	2019
url	http://umpir.ump.edu.my/id/eprint/26482/ http://umpir.ump.edu.my/id/eprint/26482/ http://umpir.ump.edu.my/id/eprint/26482/ http://umpir.ump.edu.my/id/eprint/26482/1/Recent%20developments%20on%20%28%E2%88%92%29-colchicine%20derivatives%20_%20synthesis%20and%20structure.pdf
first_indexed	2023-09-18T22:41:16Z
last_indexed	2023-09-18T22:41:16Z
_version_	1777416931283828736

Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship

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