POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata

POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata

In this study, a central composite design was employed to optimize the process variables, i.e., microwave power (75-175 W) and ethanol concentration (20-85%) on the yield of bioactive compound extraction from Andrographis paniculata. The regression analysis shows a good fit between the experimental...

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Main Authors: Chia, Vi Vien, Pang, Sook Fun, Sureena, Abdullah, M. M., Yusoff, Jolius, Gimbun
Format: Conference or Workshop Item
Language:English
Published: University of Nottingham 2019
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/26833/
http://umpir.ump.edu.my/id/eprint/26833/
http://umpir.ump.edu.my/id/eprint/26833/1/POCER1915_Microwave-Assisted%20Extraction1.pdf
id ump-26833
recordtype eprints
spelling ump-268332019-12-16T08:01:14Z http://umpir.ump.edu.my/id/eprint/26833/ POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata Chia, Vi Vien Pang, Sook Fun Sureena, Abdullah M. M., Yusoff Jolius, Gimbun TP Chemical technology In this study, a central composite design was employed to optimize the process variables, i.e., microwave power (75-175 W) and ethanol concentration (20-85%) on the yield of bioactive compound extraction from Andrographis paniculata. The regression analysis shows a good fit between the experimental data to the second-order polynomial model with a coefficient of determination (R2) value of ≈ 0.95. The optimum conditions to maximize the yield of andrographolide, 14-deoxy-11,12-didehydroandrographolide, and neoandrographolide were found at microwave power of 140 W and 85% ethanol. Experimental validation performed at the aforementioned conditions yielded AND (10.93 ± 0.053 mg/gDW), DDA (4.34 ± 0.215 mg/gDW), and NEA (5.70 ± 0.252 mg/gDW), which are comparable to those of model prediction, i.e., 10.426 mg/gDW of AND, 4.123 mg/gDW of DDA and 5.558 mg/gDW of NEA, indicating the suitability of the developed models. University of Nottingham 2019 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/26833/1/POCER1915_Microwave-Assisted%20Extraction1.pdf Chia, Vi Vien and Pang, Sook Fun and Sureena, Abdullah and M. M., Yusoff and Jolius, Gimbun (2019) POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata. In: Proceedings of the 5th Postgraduate Colloquium for Environmental Research (POCER 2019), 8-9 August 2019 , Putrajaya, Malaysia. pp. 39-41., 8. ISBN 978-967-11279-6-4 https://www.nottingham.edu.my/Conferences/POCER/News-and-Proceedings.aspx
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Chia, Vi Vien
Pang, Sook Fun
Sureena, Abdullah
M. M., Yusoff
Jolius, Gimbun
POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata
description In this study, a central composite design was employed to optimize the process variables, i.e., microwave power (75-175 W) and ethanol concentration (20-85%) on the yield of bioactive compound extraction from Andrographis paniculata. The regression analysis shows a good fit between the experimental data to the second-order polynomial model with a coefficient of determination (R2) value of ≈ 0.95. The optimum conditions to maximize the yield of andrographolide, 14-deoxy-11,12-didehydroandrographolide, and neoandrographolide were found at microwave power of 140 W and 85% ethanol. Experimental validation performed at the aforementioned conditions yielded AND (10.93 ± 0.053 mg/gDW), DDA (4.34 ± 0.215 mg/gDW), and NEA (5.70 ± 0.252 mg/gDW), which are comparable to those of model prediction, i.e., 10.426 mg/gDW of AND, 4.123 mg/gDW of DDA and 5.558 mg/gDW of NEA, indicating the suitability of the developed models.
format Conference or Workshop Item
author Chia, Vi Vien
Pang, Sook Fun
Sureena, Abdullah
M. M., Yusoff
Jolius, Gimbun
author_facet Chia, Vi Vien
Pang, Sook Fun
Sureena, Abdullah
M. M., Yusoff
Jolius, Gimbun
author_sort Chia, Vi Vien
title POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata
title_short POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata
title_full POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata
title_fullStr POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata
title_full_unstemmed POCER 1915: Microwave-Assisted Extraction of Andrographolide, 14-Deoxy-11,12-didehydroandrographolide and Neoandrographolide from Andrographis Paniculata
title_sort pocer 1915: microwave-assisted extraction of andrographolide, 14-deoxy-11,12-didehydroandrographolide and neoandrographolide from andrographis paniculata
publisher University of Nottingham
publishDate 2019
url http://umpir.ump.edu.my/id/eprint/26833/
http://umpir.ump.edu.my/id/eprint/26833/
http://umpir.ump.edu.my/id/eprint/26833/1/POCER1915_Microwave-Assisted%20Extraction1.pdf
first_indexed 2023-09-18T22:42:01Z
last_indexed 2023-09-18T22:42:01Z
_version_ 1777416978419417088

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