Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application

This work aims to evaluate carrageenan as a potential biocomposite for hard capsule in the drug delivery application. The interaction between carrageenan and isovanillin was studied by modeling their molecule electronic surface potential and enthalpy. Simulation results showed that the physical cros...

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Main Authors:	Fatmawati, Adam, Mohd Aiman, Hamdan, Siti Hana, Abu Bakar, M. M., Yusoff, Rajan, Jose
Format:	Article
Language:	English
Published:	Taylor & Francis 2020
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/28109/ http://umpir.ump.edu.my/id/eprint/28109/ http://umpir.ump.edu.my/id/eprint/28109/1/Molecular%20recognition%20of%20isovanillin%20crosslinked%20carrageenan1.pdf

id	ump-28109
recordtype	eprints
spelling	ump-281092020-03-11T04:09:14Z http://umpir.ump.edu.my/id/eprint/28109/ Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application Fatmawati, Adam Mohd Aiman, Hamdan Siti Hana, Abu Bakar M. M., Yusoff Rajan, Jose TP Chemical technology This work aims to evaluate carrageenan as a potential biocomposite for hard capsule in the drug delivery application. The interaction between carrageenan and isovanillin was studied by modeling their molecule electronic surface potential and enthalpy. Simulation results showed that the physical crosslinking is established at two points: hydroxyl (isovanillin)-sulfate (carrageenan) and aldehyde (isovanillin)-hydroxyl (carrageenan) with strong hydrogen bonds (H-bond) lengths of 1.74–1.79 Å. FTIR showed that isovanillin addition increased the intermolecular H-bond up to 57% as the OH-stretching is shifted from 3376 to 3356 cm−1. At 3 wt.% isovanillin concentration, the tensile strength of the biocomposite film increased to 49% and the hard capsule developed from the formulation solution disintegrated in 9 min. Upon contact with water, the H-bonds broke and caused the carrageenan fragments to dissolve in deionized water. The disintegration and mechanical properties of the crosslinked carrageenan biocomposite film made from renewable and low price materials facilitate the application of the film as hard capsules for drug delivery. Taylor & Francis 2020 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/28109/1/Molecular%20recognition%20of%20isovanillin%20crosslinked%20carrageenan1.pdf Fatmawati, Adam and Mohd Aiman, Hamdan and Siti Hana, Abu Bakar and M. M., Yusoff and Rajan, Jose (2020) Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application. Chemical Engineering Communications. pp. 1-13. ISSN 1563-5201 https://www.tandfonline.com/doi/full/10.1080/00986445.2020.1731802
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Fatmawati, Adam Mohd Aiman, Hamdan Siti Hana, Abu Bakar M. M., Yusoff Rajan, Jose Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application
description	This work aims to evaluate carrageenan as a potential biocomposite for hard capsule in the drug delivery application. The interaction between carrageenan and isovanillin was studied by modeling their molecule electronic surface potential and enthalpy. Simulation results showed that the physical crosslinking is established at two points: hydroxyl (isovanillin)-sulfate (carrageenan) and aldehyde (isovanillin)-hydroxyl (carrageenan) with strong hydrogen bonds (H-bond) lengths of 1.74–1.79 Å. FTIR showed that isovanillin addition increased the intermolecular H-bond up to 57% as the OH-stretching is shifted from 3376 to 3356 cm−1. At 3 wt.% isovanillin concentration, the tensile strength of the biocomposite film increased to 49% and the hard capsule developed from the formulation solution disintegrated in 9 min. Upon contact with water, the H-bonds broke and caused the carrageenan fragments to dissolve in deionized water. The disintegration and mechanical properties of the crosslinked carrageenan biocomposite film made from renewable and low price materials facilitate the application of the film as hard capsules for drug delivery.
format	Article
author	Fatmawati, Adam Mohd Aiman, Hamdan Siti Hana, Abu Bakar M. M., Yusoff Rajan, Jose
author_facet	Fatmawati, Adam Mohd Aiman, Hamdan Siti Hana, Abu Bakar M. M., Yusoff Rajan, Jose
author_sort	Fatmawati, Adam
title	Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application
title_short	Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application
title_full	Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application
title_fullStr	Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application
title_full_unstemmed	Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application
title_sort	molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application
publisher	Taylor & Francis
publishDate	2020
url	http://umpir.ump.edu.my/id/eprint/28109/ http://umpir.ump.edu.my/id/eprint/28109/ http://umpir.ump.edu.my/id/eprint/28109/1/Molecular%20recognition%20of%20isovanillin%20crosslinked%20carrageenan1.pdf
first_indexed	2023-09-18T22:44:04Z
last_indexed	2023-09-18T22:44:04Z
_version_	1777417106880462848

Molecular recognition of isovanillin crosslinked carrageenan biocomposite for drug delivery application

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