Development of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins

The purpose of the research is to develop a novel type of drug delivery carrier with the capability of encapsulating multiple drugs and release the drugs in controlled manner. Nanotechnology as a delivery platform offers very promising applications in drug delivery. Polymeric drug delivery devices w...

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Main Author:	Mohd Amiruddin Fadzli, Mohamad Zaini
Format:	Undergraduates Project Papers
Published:	2010
Subjects:	TA Engineering (General). Civil engineering (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/3090/ http://umpir.ump.edu.my/id/eprint/3090/

id	ump-3090
recordtype	eprints
spelling	ump-30902014-06-18T01:05:14Z http://umpir.ump.edu.my/id/eprint/3090/ Development of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins Mohd Amiruddin Fadzli, Mohamad Zaini TA Engineering (General). Civil engineering (General) The purpose of the research is to develop a novel type of drug delivery carrier with the capability of encapsulating multiple drugs and release the drugs in controlled manner. Nanotechnology as a delivery platform offers very promising applications in drug delivery. Polymeric drug delivery devices were successfully developed via electrospinning technique using PCL, PLLA and PLLA-CL biodegradable polymers. Coaxial electrospinning configurations was used to encapsulate three proteins which are BSA, lysozyme and IgG into the electrospun nanofibers. Using the configuration, two separate polymers solutions flowed through two different capillaries which are coaxial with a smaller capillary inside a larger capillary. A number of processing parameters were investigated during the electrospinning process which are formulation of drug loading, the type of polymer and drug and the concentration of polymer and drug. The morphology of the electrospun nanofibers was analyzed using Scanning Electron Microscopy (SEM). The mechanical property was analyzed by using tensile strength and UVSpectrophotometer was used to study the proteins release profile. The results showed that the incorporated proteins could be controlled release by adjusting the process parameters and the proteins structure and bioactivity are maintained. Polymeric drug delivery device is able deliver a pre-determined amount of drug over specific amount of time in a predictable manner. It can improve the effectiveness of drug therapy by increasing the therapeutic activity and reducing the number of drug administrations. 2010-12 Undergraduates Project Papers NonPeerReviewed Mohd Amiruddin Fadzli, Mohamad Zaini (2010) Development of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins. Faculty of Chemical & Natural Resources Engineering , Universiti Malaysia Pahang . http://iportal.ump.edu.my/lib/item?id=chamo:57034&theme=UMP2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
topic	TA Engineering (General). Civil engineering (General)
spellingShingle	TA Engineering (General). Civil engineering (General) Mohd Amiruddin Fadzli, Mohamad Zaini Development of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins
description	The purpose of the research is to develop a novel type of drug delivery carrier with the capability of encapsulating multiple drugs and release the drugs in controlled manner. Nanotechnology as a delivery platform offers very promising applications in drug delivery. Polymeric drug delivery devices were successfully developed via electrospinning technique using PCL, PLLA and PLLA-CL biodegradable polymers. Coaxial electrospinning configurations was used to encapsulate three proteins which are BSA, lysozyme and IgG into the electrospun nanofibers. Using the configuration, two separate polymers solutions flowed through two different capillaries which are coaxial with a smaller capillary inside a larger capillary. A number of processing parameters were investigated during the electrospinning process which are formulation of drug loading, the type of polymer and drug and the concentration of polymer and drug. The morphology of the electrospun nanofibers was analyzed using Scanning Electron Microscopy (SEM). The mechanical property was analyzed by using tensile strength and UVSpectrophotometer was used to study the proteins release profile. The results showed that the incorporated proteins could be controlled release by adjusting the process parameters and the proteins structure and bioactivity are maintained. Polymeric drug delivery device is able deliver a pre-determined amount of drug over specific amount of time in a predictable manner. It can improve the effectiveness of drug therapy by increasing the therapeutic activity and reducing the number of drug administrations.
format	Undergraduates Project Papers
author	Mohd Amiruddin Fadzli, Mohamad Zaini
author_facet	Mohd Amiruddin Fadzli, Mohamad Zaini
author_sort	Mohd Amiruddin Fadzli, Mohamad Zaini
title	Development of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins
title_short	Development of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins
title_full	Development of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins
title_fullStr	Development of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins
title_full_unstemmed	Development of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins
title_sort	development of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins
publishDate	2010
url	http://umpir.ump.edu.my/id/eprint/3090/ http://umpir.ump.edu.my/id/eprint/3090/
first_indexed	2023-09-18T21:57:07Z
last_indexed	2023-09-18T21:57:07Z
_version_	1777414153241100288

Development of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins

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