Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats

We evaluated the effects of a standardized Labisia pumila var. alata (LPva) extract on body weight change, hydroxysteroid (11-beta) dehydrogenase 1 (HSD1 1B1) expressions and corticosterone (CORT) level in ovariectomized (OVX) rats. The decoction of LPva has been used for generations among Malay wo...

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Main Authors:	M. M., Yusoff, Fazliana, Mansor, Gu, Harvest F., Östenson, Claes-Göran, Wan Mohamud, Wan Nazaimoon
Format:	Article
Language:	English
Published:	Springer Japan 2012
Subjects:	Q Science (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/4728/ http://umpir.ump.edu.my/id/eprint/4728/ http://umpir.ump.edu.my/id/eprint/4728/ http://umpir.ump.edu.my/id/eprint/4728/1/Labisia%20pumila%20extract%20down-regulates%20hydroxysteroid%20%2811-beta%29.pdf

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spelling	ump-47282018-07-27T03:26:46Z http://umpir.ump.edu.my/id/eprint/4728/ Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats M. M., Yusoff Fazliana, Mansor Gu, Harvest F. Östenson, Claes-Göran Wan Mohamud, Wan Nazaimoon Q Science (General) We evaluated the effects of a standardized Labisia pumila var. alata (LPva) extract on body weight change, hydroxysteroid (11-beta) dehydrogenase 1 (HSD1 1B1) expressions and corticosterone (CORT) level in ovariectomized (OVX) rats. The decoction of LPva has been used for generations among Malay women in Malaysia to maintain a healthy reproductive system.Thirty-six Sprague–Dawley OVX rats were treated orally with LPva extract (10, 20 or 50 mg/kg/day) or estrogen replacement (ERT) for 30 days. Sham operated rats were used as controls. Compared to untreated OVX rats, LPva-treated rats showed less weight gain and had significantly down-regulated HSD11B1 mRNA in liver tissues. HSD11B1 mRNA in adipose tissues increased by 55% (p\0.05) in OVX rats but normalized in rats treated with LPva. Similarly, there was significant down-regulation (p\0.05) of protein levels of HSD11B1 in both liver and adipose tissue of LPva and ERT groups, and CORT levels were significantly reduced in both groups of rats. This is the first study ever conducted to evaluate the beneficial effects of LPva in relation to weight gain caused by estrogen insufficiency. Results implied that the bioactive components in LPva extract affect not only HSD11B1 expressions in both adipose and liver tissues but also decrease circulating CORT. The extract should be explored for its potential use as a natural remedy for weight management. Springer Japan 2012-04 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/4728/1/Labisia%20pumila%20extract%20down-regulates%20hydroxysteroid%20%2811-beta%29.pdf M. M., Yusoff and Fazliana, Mansor and Gu, Harvest F. and Östenson, Claes-Göran and Wan Mohamud, Wan Nazaimoon (2012) Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats. Journal of Natural Medicines, 66 (2). pp. 257-264. ISSN 1340-3443(print); 1861-0293(online) https://doi.org/10.1007/s11418-011-0575-1 DOI: 10.1007/s11418-011-0575-1
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) M. M., Yusoff Fazliana, Mansor Gu, Harvest F. Östenson, Claes-Göran Wan Mohamud, Wan Nazaimoon Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
description	We evaluated the effects of a standardized Labisia pumila var. alata (LPva) extract on body weight change, hydroxysteroid (11-beta) dehydrogenase 1 (HSD1 1B1) expressions and corticosterone (CORT) level in ovariectomized (OVX) rats. The decoction of LPva has been used for generations among Malay women in Malaysia to maintain a healthy reproductive system.Thirty-six Sprague–Dawley OVX rats were treated orally with LPva extract (10, 20 or 50 mg/kg/day) or estrogen replacement (ERT) for 30 days. Sham operated rats were used as controls. Compared to untreated OVX rats, LPva-treated rats showed less weight gain and had significantly down-regulated HSD11B1 mRNA in liver tissues. HSD11B1 mRNA in adipose tissues increased by 55% (p\0.05) in OVX rats but normalized in rats treated with LPva. Similarly, there was significant down-regulation (p\0.05) of protein levels of HSD11B1 in both liver and adipose tissue of LPva and ERT groups, and CORT levels were significantly reduced in both groups of rats. This is the first study ever conducted to evaluate the beneficial effects of LPva in relation to weight gain caused by estrogen insufficiency. Results implied that the bioactive components in LPva extract affect not only HSD11B1 expressions in both adipose and liver tissues but also decrease circulating CORT. The extract should be explored for its potential use as a natural remedy for weight management.
format	Article
author	M. M., Yusoff Fazliana, Mansor Gu, Harvest F. Östenson, Claes-Göran Wan Mohamud, Wan Nazaimoon
author_facet	M. M., Yusoff Fazliana, Mansor Gu, Harvest F. Östenson, Claes-Göran Wan Mohamud, Wan Nazaimoon
author_sort	M. M., Yusoff
title	Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
title_short	Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
title_full	Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
title_fullStr	Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
title_full_unstemmed	Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats
title_sort	labisia pumila extract down-regulates hydroxysteroid (11-beta) dehydrogenase 1 expression and corticosterone levels in ovariectomized rats
publisher	Springer Japan
publishDate	2012
url	http://umpir.ump.edu.my/id/eprint/4728/ http://umpir.ump.edu.my/id/eprint/4728/ http://umpir.ump.edu.my/id/eprint/4728/ http://umpir.ump.edu.my/id/eprint/4728/1/Labisia%20pumila%20extract%20down-regulates%20hydroxysteroid%20%2811-beta%29.pdf
first_indexed	2023-09-18T21:59:36Z
last_indexed	2023-09-18T21:59:36Z
_version_	1777414309592170496

Labisia Pumila Extract Down-Regulates Hydroxysteroid (11-beta) Dehydrogenase 1 Expression and Corticosterone Levels in Ovariectomized Rats

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