Synthesis, Biological Evaluation and Study of the Effect of Various N-Substituents on the Thermal Stabilities of Some New Diethanolamine Derivatives

Diethanolamine and its derivatives are of considerable interest in medicinal and other industrial products. A series of new diethanolamine derivatives has been synthesized and characterized by 1H NMR, 13C NMR, FTIR and mass spectrometry. All synthesized compounds have been tested for their in vitro...

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Main Authors:	Akhtar, Muhammad Nadeem, Yar, Muhammad, Mushtaq, Nafeesa, Afzal, Sadia, Khan, Abdul Samad, Khan, Islam Ullah, Seema, Zareen, Shahzad, Sohail Anjum, Khan, Zulfiqar Ali, Naqvi, Syed Ali Raza, Mahmood, Nasir, Tahir, Lubna
Format:	Article
Language:	English
Published:	Asian J. Chem 2013
Subjects:	QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/5194/ http://umpir.ump.edu.my/id/eprint/5194/ http://umpir.ump.edu.my/id/eprint/5194/ http://umpir.ump.edu.my/id/eprint/5194/1/fist-2013-nadeem-artSynthesisBiologicalEvaluation.pdf

id	ump-5194
recordtype	eprints
spelling	ump-51942018-04-19T01:02:55Z http://umpir.ump.edu.my/id/eprint/5194/ Synthesis, Biological Evaluation and Study of the Effect of Various N-Substituents on the Thermal Stabilities of Some New Diethanolamine Derivatives Akhtar, Muhammad Nadeem Yar, Muhammad Mushtaq, Nafeesa Afzal, Sadia Khan, Abdul Samad Khan, Islam Ullah Seema, Zareen Shahzad, Sohail Anjum Khan, Zulfiqar Ali Naqvi, Syed Ali Raza Mahmood, Nasir Tahir, Lubna QD Chemistry Diethanolamine and its derivatives are of considerable interest in medicinal and other industrial products. A series of new diethanolamine derivatives has been synthesized and characterized by 1H NMR, 13C NMR, FTIR and mass spectrometry. All synthesized compounds have been tested for their in vitro antibacterial activity against pathogenic microorganisms Escherichia coli, Staphylococcus aureus, Micrococcus luteus, Pseudomonas aeruginosa, Bacillus subtilis, Pasteurrella mutocida, Rhizopus oryzae and Salmonella typhi. Among the tested compounds, compounds 2a, 2b, 2c, 3a and 4b have been found to be most potent members, which inhibited most of the pathogens used in the assay. Diethanolamine must posses tosyl or trifluoro groups in order to have good antimicrobial activities. All synthesized derivatives exhibited average FRAP activity and considerably good metal chelating activity and compound 2c showed excellent ABTS radical scavanging among all tested derivatives. Thermal stability and the effect of various N-protected groups on the thermal stability and degradation of selected diethanolamine derivatives (free flowing oils at room temperature and solid derivative 2a) has been studied by TGA and DSC analysis. Asian J. Chem 2013 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/5194/1/fist-2013-nadeem-artSynthesisBiologicalEvaluation.pdf Akhtar, Muhammad Nadeem and Yar, Muhammad and Mushtaq, Nafeesa and Afzal, Sadia and Khan, Abdul Samad and Khan, Islam Ullah and Seema, Zareen and Shahzad, Sohail Anjum and Khan, Zulfiqar Ali and Naqvi, Syed Ali Raza and Mahmood, Nasir and Tahir, Lubna (2013) Synthesis, Biological Evaluation and Study of the Effect of Various N-Substituents on the Thermal Stabilities of Some New Diethanolamine Derivatives. Asian Journal of Chemistry , 25 (13). pp. 7297-7304. ISSN 0970-7077 http://dx.doi.org/10.14233/ajchem.2013.14543 DOI: 10.14233/ajchem.2013.14543
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Akhtar, Muhammad Nadeem Yar, Muhammad Mushtaq, Nafeesa Afzal, Sadia Khan, Abdul Samad Khan, Islam Ullah Seema, Zareen Shahzad, Sohail Anjum Khan, Zulfiqar Ali Naqvi, Syed Ali Raza Mahmood, Nasir Tahir, Lubna Synthesis, Biological Evaluation and Study of the Effect of Various N-Substituents on the Thermal Stabilities of Some New Diethanolamine Derivatives
description	Diethanolamine and its derivatives are of considerable interest in medicinal and other industrial products. A series of new diethanolamine derivatives has been synthesized and characterized by 1H NMR, 13C NMR, FTIR and mass spectrometry. All synthesized compounds have been tested for their in vitro antibacterial activity against pathogenic microorganisms Escherichia coli, Staphylococcus aureus, Micrococcus luteus, Pseudomonas aeruginosa, Bacillus subtilis, Pasteurrella mutocida, Rhizopus oryzae and Salmonella typhi. Among the tested compounds, compounds 2a, 2b, 2c, 3a and 4b have been found to be most potent members, which inhibited most of the pathogens used in the assay. Diethanolamine must posses tosyl or trifluoro groups in order to have good antimicrobial activities. All synthesized derivatives exhibited average FRAP activity and considerably good metal chelating activity and compound 2c showed excellent ABTS radical scavanging among all tested derivatives. Thermal stability and the effect of various N-protected groups on the thermal stability and degradation of selected diethanolamine derivatives (free flowing oils at room temperature and solid derivative 2a) has been studied by TGA and DSC analysis.
format	Article
author	Akhtar, Muhammad Nadeem Yar, Muhammad Mushtaq, Nafeesa Afzal, Sadia Khan, Abdul Samad Khan, Islam Ullah Seema, Zareen Shahzad, Sohail Anjum Khan, Zulfiqar Ali Naqvi, Syed Ali Raza Mahmood, Nasir Tahir, Lubna
author_facet	Akhtar, Muhammad Nadeem Yar, Muhammad Mushtaq, Nafeesa Afzal, Sadia Khan, Abdul Samad Khan, Islam Ullah Seema, Zareen Shahzad, Sohail Anjum Khan, Zulfiqar Ali Naqvi, Syed Ali Raza Mahmood, Nasir Tahir, Lubna
author_sort	Akhtar, Muhammad Nadeem
title	Synthesis, Biological Evaluation and Study of the Effect of Various N-Substituents on the Thermal Stabilities of Some New Diethanolamine Derivatives
title_short	Synthesis, Biological Evaluation and Study of the Effect of Various N-Substituents on the Thermal Stabilities of Some New Diethanolamine Derivatives
title_full	Synthesis, Biological Evaluation and Study of the Effect of Various N-Substituents on the Thermal Stabilities of Some New Diethanolamine Derivatives
title_fullStr	Synthesis, Biological Evaluation and Study of the Effect of Various N-Substituents on the Thermal Stabilities of Some New Diethanolamine Derivatives
title_full_unstemmed	Synthesis, Biological Evaluation and Study of the Effect of Various N-Substituents on the Thermal Stabilities of Some New Diethanolamine Derivatives
title_sort	synthesis, biological evaluation and study of the effect of various n-substituents on the thermal stabilities of some new diethanolamine derivatives
publisher	Asian J. Chem
publishDate	2013
url	http://umpir.ump.edu.my/id/eprint/5194/ http://umpir.ump.edu.my/id/eprint/5194/ http://umpir.ump.edu.my/id/eprint/5194/ http://umpir.ump.edu.my/id/eprint/5194/1/fist-2013-nadeem-artSynthesisBiologicalEvaluation.pdf
first_indexed	2023-09-18T22:00:26Z
last_indexed	2023-09-18T22:00:26Z
_version_	1777414362320863232

Synthesis, Biological Evaluation and Study of the Effect of Various N-Substituents on the Thermal Stabilities of Some New Diethanolamine Derivatives

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