3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231
Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinon...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI - Open Access Publishing
2013
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/5212/ http://umpir.ump.edu.my/id/eprint/5212/ http://umpir.ump.edu.my/id/eprint/5212/ http://umpir.ump.edu.my/id/eprint/5212/1/fist-2013-nadeem-art3-Bromo-1-Hydroxy.pdf |
| Summary: | Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line. |
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