3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231

Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinon...

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Main Authors:	Akhtar, Muhammad Nadeem, Nadiah, Abu, Wan, Yong Ho, Swee, Keong Yeap, Noorjahan Banu, Alitheen
Format:	Article
Language:	English
Published:	MDPI - Open Access Publishing 2013
Subjects:	QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/5212/ http://umpir.ump.edu.my/id/eprint/5212/ http://umpir.ump.edu.my/id/eprint/5212/ http://umpir.ump.edu.my/id/eprint/5212/1/fist-2013-nadeem-art3-Bromo-1-Hydroxy.pdf

id	ump-5212
recordtype	eprints
spelling	ump-52122018-04-18T04:15:05Z http://umpir.ump.edu.my/id/eprint/5212/ 3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231 Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Swee, Keong Yeap Noorjahan Banu, Alitheen QD Chemistry Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line. MDPI - Open Access Publishing 2013 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/5212/1/fist-2013-nadeem-art3-Bromo-1-Hydroxy.pdf Akhtar, Muhammad Nadeem and Nadiah, Abu and Wan, Yong Ho and Swee, Keong Yeap and Noorjahan Banu, Alitheen (2013) 3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231. Molecules, 18 (9). pp. 10367-10377. ISSN 1420-3049 (print); 1420-3049 (online) http://dx.doi.org/10.3390/molecules180910367 DOI: 10.3390/molecules180910367
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Swee, Keong Yeap Noorjahan Banu, Alitheen 3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231
description	Breast cancer is becoming more prominent in women today. As of now, there are no effective treatments in treating metastatic breast cancer. We have tested the cytotoxic and anti-migration effects of BHAQ, a synthesized anthraquinone, on two breast cancer cell lines, MCF-7 and MDA-MB231. Anthraquinones are an interesting class of molecules that display a wide spectrum of biological applications, including anticancer properties. Cellular inhibition was tested through a MTT assay, double acridine orange/propidium iodide staining and FACS cell cycle analysis. Inhibition of migration was tested by the wound healing method, and migration through a Boyden chamber. BHAQ was cytotoxic towards both cell lines in a dose dependent and possibly cell-dependent manner. Additionally, BHAQ also inhibited the migration of the highly metastatic MDA-MB231 cell line.
format	Article
author	Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Swee, Keong Yeap Noorjahan Banu, Alitheen
author_facet	Akhtar, Muhammad Nadeem Nadiah, Abu Wan, Yong Ho Swee, Keong Yeap Noorjahan Banu, Alitheen
author_sort	Akhtar, Muhammad Nadeem
title	3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231
title_short	3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231
title_full	3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231
title_fullStr	3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231
title_full_unstemmed	3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231
title_sort	3-bromo-1-hydroxy-9,10-anthraquinone (bhaq) inhibits growth and migration of the human breast cancer cell lines mcf-7 and mda-mb231
publisher	MDPI - Open Access Publishing
publishDate	2013
url	http://umpir.ump.edu.my/id/eprint/5212/ http://umpir.ump.edu.my/id/eprint/5212/ http://umpir.ump.edu.my/id/eprint/5212/ http://umpir.ump.edu.my/id/eprint/5212/1/fist-2013-nadeem-art3-Bromo-1-Hydroxy.pdf
first_indexed	2023-09-18T22:00:29Z
last_indexed	2023-09-18T22:00:29Z
_version_	1777414364494561280

3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231

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