Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata

The phytochemical investigation of the ethylacetate-soluble fraction of Caryopteris odorata (Ham. ex Roxb.) led to the isolation of four new iridoid glucosides (1–4): 8-O-trans-cinnamoyl caryoptoside (1), 8-O-trans-cinnamoyl shanzhiside methylester (2), 8-O-trans-cinnamoyl mussaenoside (3) and 8-O-c...

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Main Authors:	Akhtar, Muhammad Nadeem, Shahzadi, Tayyab, Abbasi, Muhammad Athar, Ur-Rehman, Aziz, Riaz, Tauheed, Khan, Khalid Mohammed, Mohd Ashraf, Ahmad, Afzal, Iftikhar, Ajaib, Muhammad
Format:	Article
Language:	English
Published:	Taylor & Francis 2013
Subjects:	QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/5215/ http://umpir.ump.edu.my/id/eprint/5215/ http://umpir.ump.edu.my/id/eprint/5215/ http://umpir.ump.edu.my/id/eprint/5215/1/fist-2013-nadeem-artAntioxidantandLipoxygenase.pdf

id	ump-5215
recordtype	eprints
spelling	ump-52152018-02-06T07:40:05Z http://umpir.ump.edu.my/id/eprint/5215/ Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata Akhtar, Muhammad Nadeem Shahzadi, Tayyab Abbasi, Muhammad Athar Ur-Rehman, Aziz Riaz, Tauheed Khan, Khalid Mohammed Mohd Ashraf, Ahmad Afzal, Iftikhar Ajaib, Muhammad QD Chemistry The phytochemical investigation of the ethylacetate-soluble fraction of Caryopteris odorata (Ham. ex Roxb.) led to the isolation of four new iridoid glucosides (1–4): 8-O-trans-cinnamoyl caryoptoside (1), 8-O-trans-cinnamoyl shanzhiside methylester (2), 8-O-trans-cinnamoyl mussaenoside (3) and 8-O-cafeoyl massenoside (4). The structures of these compounds were determined by FAB-MS, IR, 1D and 2D-NMR spectroscopy and by comparing with the published data of the closely related compounds. The antioxidant potential of the isolated iridoids (1–4) was evaluated relative to conventionally used standards and these molecules exhibited good antioxidant potential. Moreover, their inhibitory potential was also screened against three enzymes, namely acetyl cholinesterase, butyrylcholinesterase and lipoxygenase. These iridoid glucosides were found to be inactive against acetyl and butyrylcholinesterases but active against lipoxygenase. Taylor & Francis 2013 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/5215/1/fist-2013-nadeem-artAntioxidantandLipoxygenase.pdf Akhtar, Muhammad Nadeem and Shahzadi, Tayyab and Abbasi, Muhammad Athar and Ur-Rehman, Aziz and Riaz, Tauheed and Khan, Khalid Mohammed and Mohd Ashraf, Ahmad and Afzal, Iftikhar and Ajaib, Muhammad (2013) Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata. Natural Product Research: Formerly Natural Product Letters, 27 (4-5). pp. 302-313. ISSN 1478-6419 (print); 1478-6427 (online) http://dx.doi.org/10.1080/14786419.2012.668692 DOI: 10.1080/14786419.2012.668692
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Akhtar, Muhammad Nadeem Shahzadi, Tayyab Abbasi, Muhammad Athar Ur-Rehman, Aziz Riaz, Tauheed Khan, Khalid Mohammed Mohd Ashraf, Ahmad Afzal, Iftikhar Ajaib, Muhammad Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata
description	The phytochemical investigation of the ethylacetate-soluble fraction of Caryopteris odorata (Ham. ex Roxb.) led to the isolation of four new iridoid glucosides (1–4): 8-O-trans-cinnamoyl caryoptoside (1), 8-O-trans-cinnamoyl shanzhiside methylester (2), 8-O-trans-cinnamoyl mussaenoside (3) and 8-O-cafeoyl massenoside (4). The structures of these compounds were determined by FAB-MS, IR, 1D and 2D-NMR spectroscopy and by comparing with the published data of the closely related compounds. The antioxidant potential of the isolated iridoids (1–4) was evaluated relative to conventionally used standards and these molecules exhibited good antioxidant potential. Moreover, their inhibitory potential was also screened against three enzymes, namely acetyl cholinesterase, butyrylcholinesterase and lipoxygenase. These iridoid glucosides were found to be inactive against acetyl and butyrylcholinesterases but active against lipoxygenase.
format	Article
author	Akhtar, Muhammad Nadeem Shahzadi, Tayyab Abbasi, Muhammad Athar Ur-Rehman, Aziz Riaz, Tauheed Khan, Khalid Mohammed Mohd Ashraf, Ahmad Afzal, Iftikhar Ajaib, Muhammad
author_facet	Akhtar, Muhammad Nadeem Shahzadi, Tayyab Abbasi, Muhammad Athar Ur-Rehman, Aziz Riaz, Tauheed Khan, Khalid Mohammed Mohd Ashraf, Ahmad Afzal, Iftikhar Ajaib, Muhammad
author_sort	Akhtar, Muhammad Nadeem
title	Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata
title_short	Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata
title_full	Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata
title_fullStr	Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata
title_full_unstemmed	Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata
title_sort	antioxidant and lipoxygenase inhibiting new iridoid glucosides from caryopteris odorata
publisher	Taylor & Francis
publishDate	2013
url	http://umpir.ump.edu.my/id/eprint/5215/ http://umpir.ump.edu.my/id/eprint/5215/ http://umpir.ump.edu.my/id/eprint/5215/ http://umpir.ump.edu.my/id/eprint/5215/1/fist-2013-nadeem-artAntioxidantandLipoxygenase.pdf
first_indexed	2023-09-18T22:00:29Z
last_indexed	2023-09-18T22:00:29Z
_version_	1777414364928671744

Antioxidant and Lipoxygenase Inhibiting New Iridoid Glucosides from Caryopteris Odorata

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