Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the κ-opioid Receptor and KATP

The present study investigated the analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone or BHMC in a mouse model of chronic constriction injury-induced neuropathic pain. It was demonstrated that intraperitoneal administration of BHMC...

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Main Authors: Akhtar, Muhammad Nadeem, Shaik Ibrahim, Khalivulla, Lee, Ming-Tatt, Nordin, Lajis, Enoch Kumar, Perimal, Ahmad, Akira, Daud Israf, Ali, Mohd Roslan, Sulaiman
Format: Article
Language:English
Published: Elsevier 2013
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spelling ump-52452018-04-19T00:56:00Z http://umpir.ump.edu.my/id/eprint/5245/ Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the κ-opioid Receptor and KATP Akhtar, Muhammad Nadeem Shaik Ibrahim, Khalivulla Lee, Ming-Tatt Nordin, Lajis Enoch Kumar, Perimal Ahmad, Akira Daud Israf, Ali Mohd Roslan, Sulaiman QR Microbiology The present study investigated the analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone or BHMC in a mouse model of chronic constriction injury-induced neuropathic pain. It was demonstrated that intraperitoneal administration of BHMC (0.03, 0.1, 0.3 and 1.0 mg/kg) exhibited dose-dependent inhibition of chronic constriction injury-induced neuropathic pain in mice, when evaluated using Randall–Selitto mechanical analgesiometer. It was also demonstrated that pretreatment of naloxone (non-selective opioid receptor blocker), nor-binaltorphimine (nor-BNI, selective κ-opioid receptor blocker), but not β-funaltrexamine (β-FN, selective μ-opioid receptor blocker) and naltrindole hydrochloride (NTI, selective δ-opioid receptor blocker), reversed the anti-nociceptive effect of BHMC. In addition, the analgesic effect of BHMC was also reverted by pretreatment of 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one (ODQ, soluble guanosyl cyclase blocker) and glibenclamide (ATP-sensitive potassium channel blocker) but not Nω-nitro-l-arginine (l-NAME, a nitric oxide synthase blocker). Taken together, the present study demonstrated that the systemic administration of BHMC attenuated chronic constriction, injury-induced neuropathic pain. We also suggested that the possible mechanisms include κ-opioid receptor activation and nitric oxide-independent cyclic guanosine monophosphate activation of ATP-sensitive potassium channel opening. Elsevier 2013 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/5245/1/fist-2013-nadeem-artAnti-HyperalgesicEffect.pdf Akhtar, Muhammad Nadeem and Shaik Ibrahim, Khalivulla and Lee, Ming-Tatt and Nordin, Lajis and Enoch Kumar, Perimal and Ahmad, Akira and Daud Israf, Ali and Mohd Roslan, Sulaiman (2013) Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the κ-opioid Receptor and KATP. Pharmacology Biochemistry and Behavior, 114-115. pp. 58-63. ISSN 0091-3057 (print); 1873-5177 (online) http://dx.doi.org/10.1016/j.pbb.2013.10.019 DOI: 10.1016/j.pbb.2013.10.019
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic QR Microbiology
spellingShingle QR Microbiology
Akhtar, Muhammad Nadeem
Shaik Ibrahim, Khalivulla
Lee, Ming-Tatt
Nordin, Lajis
Enoch Kumar, Perimal
Ahmad, Akira
Daud Israf, Ali
Mohd Roslan, Sulaiman
Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the κ-opioid Receptor and KATP
description The present study investigated the analgesic effect of a novel synthetic cyclohexanone derivative, 2,6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone or BHMC in a mouse model of chronic constriction injury-induced neuropathic pain. It was demonstrated that intraperitoneal administration of BHMC (0.03, 0.1, 0.3 and 1.0 mg/kg) exhibited dose-dependent inhibition of chronic constriction injury-induced neuropathic pain in mice, when evaluated using Randall–Selitto mechanical analgesiometer. It was also demonstrated that pretreatment of naloxone (non-selective opioid receptor blocker), nor-binaltorphimine (nor-BNI, selective κ-opioid receptor blocker), but not β-funaltrexamine (β-FN, selective μ-opioid receptor blocker) and naltrindole hydrochloride (NTI, selective δ-opioid receptor blocker), reversed the anti-nociceptive effect of BHMC. In addition, the analgesic effect of BHMC was also reverted by pretreatment of 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one (ODQ, soluble guanosyl cyclase blocker) and glibenclamide (ATP-sensitive potassium channel blocker) but not Nω-nitro-l-arginine (l-NAME, a nitric oxide synthase blocker). Taken together, the present study demonstrated that the systemic administration of BHMC attenuated chronic constriction, injury-induced neuropathic pain. We also suggested that the possible mechanisms include κ-opioid receptor activation and nitric oxide-independent cyclic guanosine monophosphate activation of ATP-sensitive potassium channel opening.
format Article
author Akhtar, Muhammad Nadeem
Shaik Ibrahim, Khalivulla
Lee, Ming-Tatt
Nordin, Lajis
Enoch Kumar, Perimal
Ahmad, Akira
Daud Israf, Ali
Mohd Roslan, Sulaiman
author_facet Akhtar, Muhammad Nadeem
Shaik Ibrahim, Khalivulla
Lee, Ming-Tatt
Nordin, Lajis
Enoch Kumar, Perimal
Ahmad, Akira
Daud Israf, Ali
Mohd Roslan, Sulaiman
author_sort Akhtar, Muhammad Nadeem
title Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the κ-opioid Receptor and KATP
title_short Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the κ-opioid Receptor and KATP
title_full Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the κ-opioid Receptor and KATP
title_fullStr Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the κ-opioid Receptor and KATP
title_full_unstemmed Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the κ-opioid Receptor and KATP
title_sort anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the îº-opioid receptor and katp
publisher Elsevier
publishDate 2013
url http://umpir.ump.edu.my/id/eprint/5245/
http://umpir.ump.edu.my/id/eprint/5245/
http://umpir.ump.edu.my/id/eprint/5245/
http://umpir.ump.edu.my/id/eprint/5245/1/fist-2013-nadeem-artAnti-HyperalgesicEffect.pdf
first_indexed 2023-09-18T22:00:30Z
last_indexed 2023-09-18T22:00:30Z
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