Product Optimization of a Fed-batch Fermentation Process

This paper discusses the development of constrained optimization strategies for a fed- batch penicillin fermentation process. To facilitate the study, a mathematical model of the system is developed based on published materials, and simulated using MATLAB software. Good agreement is obtained when t...

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Main Authors: Noor Asma Fazli, Abdul Samad, Arshad, Ahmad, Mohd Kamaruddin, Abd Hamid
Format: Conference or Workshop Item
Language:English
Published: 2007
Subjects:
Online Access:http://umpir.ump.edu.my/id/eprint/6218/
http://umpir.ump.edu.my/id/eprint/6218/1/fkksa-2007_proceeding.pdf
id ump-6218
recordtype eprints
spelling ump-62182018-05-04T07:59:19Z http://umpir.ump.edu.my/id/eprint/6218/ Product Optimization of a Fed-batch Fermentation Process Noor Asma Fazli, Abdul Samad Arshad, Ahmad Mohd Kamaruddin, Abd Hamid TP Chemical technology This paper discusses the development of constrained optimization strategies for a fed- batch penicillin fermentation process. To facilitate the study, a mathematical model of the system is developed based on published materials, and simulated using MATLAB software. Good agreement is obtained when the results are validated against published work. To provide on-line estimates of the difficult to measure penicillin concentration, Partial Least Squares model is employed. Using these estimates, good control of product concentration is established thus enabling it to be implemented as part of product concentration control loop. Further improvements are introduced using dynamic optimization aiming at increasing the achievable product concentration while satisfying all process constraints. Two strategies are considered. These are optimal control policy using direct-shooting algorithm and unconstrained Dynamic Matrix Control (DMC). From this two optimization approaches, it is possible to estimate the optimal operating conditions as substrate feed rate so that the systems presents high performance within threshold value limit. The result also revealed that the use of DMC approach is superior the direct shooting method in term of the penicillin concentration as well as penicillin purity. Results obtained in this study have exposed the potentials of dynamic optimization schemes in improving the product purity in a fed-batch fermentation process. 2007 Conference or Workshop Item PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6218/1/fkksa-2007_proceeding.pdf Noor Asma Fazli, Abdul Samad and Arshad, Ahmad and Mohd Kamaruddin, Abd Hamid (2007) Product Optimization of a Fed-batch Fermentation Process. In: Proceedings of European Congress of Chemical Engineering (ECCE-6) , 16-20 September 2007 , Copenhagen. pp. 1-17..
repository_type Digital Repository
institution_category Local University
institution Universiti Malaysia Pahang
building UMP Institutional Repository
collection Online Access
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Noor Asma Fazli, Abdul Samad
Arshad, Ahmad
Mohd Kamaruddin, Abd Hamid
Product Optimization of a Fed-batch Fermentation Process
description This paper discusses the development of constrained optimization strategies for a fed- batch penicillin fermentation process. To facilitate the study, a mathematical model of the system is developed based on published materials, and simulated using MATLAB software. Good agreement is obtained when the results are validated against published work. To provide on-line estimates of the difficult to measure penicillin concentration, Partial Least Squares model is employed. Using these estimates, good control of product concentration is established thus enabling it to be implemented as part of product concentration control loop. Further improvements are introduced using dynamic optimization aiming at increasing the achievable product concentration while satisfying all process constraints. Two strategies are considered. These are optimal control policy using direct-shooting algorithm and unconstrained Dynamic Matrix Control (DMC). From this two optimization approaches, it is possible to estimate the optimal operating conditions as substrate feed rate so that the systems presents high performance within threshold value limit. The result also revealed that the use of DMC approach is superior the direct shooting method in term of the penicillin concentration as well as penicillin purity. Results obtained in this study have exposed the potentials of dynamic optimization schemes in improving the product purity in a fed-batch fermentation process.
format Conference or Workshop Item
author Noor Asma Fazli, Abdul Samad
Arshad, Ahmad
Mohd Kamaruddin, Abd Hamid
author_facet Noor Asma Fazli, Abdul Samad
Arshad, Ahmad
Mohd Kamaruddin, Abd Hamid
author_sort Noor Asma Fazli, Abdul Samad
title Product Optimization of a Fed-batch Fermentation Process
title_short Product Optimization of a Fed-batch Fermentation Process
title_full Product Optimization of a Fed-batch Fermentation Process
title_fullStr Product Optimization of a Fed-batch Fermentation Process
title_full_unstemmed Product Optimization of a Fed-batch Fermentation Process
title_sort product optimization of a fed-batch fermentation process
publishDate 2007
url http://umpir.ump.edu.my/id/eprint/6218/
http://umpir.ump.edu.my/id/eprint/6218/1/fkksa-2007_proceeding.pdf
first_indexed 2023-09-18T22:01:48Z
last_indexed 2023-09-18T22:01:48Z
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