Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Diﬀerent Classes of Organic Solvents

Diﬀerent classes of solvents provide diﬀerent polarity values, which inﬂuence the solubility of pharmaceutical solids. In this article, the solubility of mefenamic acid in diﬀerent classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures f...

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Main Authors:	Siti Kholijah, Abdul Mudalip, Mohd R., Abu Bakar, Parveen, Jamal, Fatmawati, Adam
Format:	Article
Published:	ACS Publications 2013
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/6219/ http://umpir.ump.edu.my/id/eprint/6219/ http://umpir.ump.edu.my/id/eprint/6219/

id	ump-6219
recordtype	eprints
spelling	ump-62192018-02-05T03:04:33Z http://umpir.ump.edu.my/id/eprint/6219/ Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Diﬀerent Classes of Organic Solvents Siti Kholijah, Abdul Mudalip Mohd R., Abu Bakar Parveen, Jamal Fatmawati, Adam TP Chemical technology Diﬀerent classes of solvents provide diﬀerent polarity values, which inﬂuence the solubility of pharmaceutical solids. In this article, the solubility of mefenamic acid in diﬀerent classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures from (298 to 323) K are reported. It has been found that mefenamic acid shows high solubility in dipolar aprotic solvents(N,N-dimethylacetamide, N,N-dimethylformamide, ethyl acetate, and propanone), moderate solubility in polar protic solvents (ethanol and propan-2-ol), and poor solubility in apolar aprotic solvents (hexane, heptane, and cyclohexane) and water. ACS Publications 2013 Article PeerReviewed Siti Kholijah, Abdul Mudalip and Mohd R., Abu Bakar and Parveen, Jamal and Fatmawati, Adam (2013) Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Diﬀerent Classes of Organic Solvents. Journal of Chemical & Engineering Data, 58 (12). pp. 3447-3452. ISSN 0021-9568 http://dx.doi.org/10.1021/je400714f DOI: 10.1021/je400714f
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
topic	TP Chemical technology
spellingShingle	TP Chemical technology Siti Kholijah, Abdul Mudalip Mohd R., Abu Bakar Parveen, Jamal Fatmawati, Adam Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Diﬀerent Classes of Organic Solvents
description	Diﬀerent classes of solvents provide diﬀerent polarity values, which inﬂuence the solubility of pharmaceutical solids. In this article, the solubility of mefenamic acid in diﬀerent classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures from (298 to 323) K are reported. It has been found that mefenamic acid shows high solubility in dipolar aprotic solvents(N,N-dimethylacetamide, N,N-dimethylformamide, ethyl acetate, and propanone), moderate solubility in polar protic solvents (ethanol and propan-2-ol), and poor solubility in apolar aprotic solvents (hexane, heptane, and cyclohexane) and water.
format	Article
author	Siti Kholijah, Abdul Mudalip Mohd R., Abu Bakar Parveen, Jamal Fatmawati, Adam
author_facet	Siti Kholijah, Abdul Mudalip Mohd R., Abu Bakar Parveen, Jamal Fatmawati, Adam
author_sort	Siti Kholijah, Abdul Mudalip
title	Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Diﬀerent Classes of Organic Solvents
title_short	Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Diﬀerent Classes of Organic Solvents
title_full	Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Diﬀerent Classes of Organic Solvents
title_fullStr	Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Diﬀerent Classes of Organic Solvents
title_full_unstemmed	Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Diﬀerent Classes of Organic Solvents
title_sort	solubility and dissolution thermodynamic data of mefenamic acid crystals in diﬀerent classes of organic solvents
publisher	ACS Publications
publishDate	2013
url	http://umpir.ump.edu.my/id/eprint/6219/ http://umpir.ump.edu.my/id/eprint/6219/ http://umpir.ump.edu.my/id/eprint/6219/
first_indexed	2023-09-18T22:01:48Z
last_indexed	2023-09-18T22:01:48Z
_version_	1777414448236986368

Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Diﬀerent Classes of Organic Solvents

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