Electrospun Hydroxyethyl Cellulose Nanofibers Functionalized With Calcium Phosphate Coating for Bone Tissue Engineering

The aim of this study is to develop a facile and efficient scaffold from electrospun hydroxyethyl cellulose (HEC) functionalized with bone-like calcium phosphate (CaP). The HEC/PVA nanofibers were fabricated by electrospinning and mineralized by incubating in 10× simulated body fluid (SBF) for diffe...

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Main Authors:	Sugandha, Chahal, Jahir Hussain, Fathima Shahitha, Anuj, Kumar, M. M., Yusoff, Mohamad Syaiful Bahari, Abdull Rasad
Format:	Article
Language:	English English
Published:	Royal Society of Chemistry 2015
Subjects:	Q Science (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/6255/ http://umpir.ump.edu.my/id/eprint/6255/ http://umpir.ump.edu.my/id/eprint/6255/ http://umpir.ump.edu.my/id/eprint/6255/1/Electrospun%20Hydroxyethyl%20Cellulose%20Nanofibers%20Functionalized%20With%20Calcium%20Phosphate%20Coating%20For%20Bone%20Tissue%20Engineering.pdf http://umpir.ump.edu.my/id/eprint/6255/7/fist-2015-fathima-electrospun%20hydroxyethyl%20cellulose%20nanofibers.pdf

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spelling	ump-62552018-07-27T08:24:56Z http://umpir.ump.edu.my/id/eprint/6255/ Electrospun Hydroxyethyl Cellulose Nanofibers Functionalized With Calcium Phosphate Coating for Bone Tissue Engineering Sugandha, Chahal Jahir Hussain, Fathima Shahitha Anuj, Kumar M. M., Yusoff Mohamad Syaiful Bahari, Abdull Rasad Q Science (General) The aim of this study is to develop a facile and efficient scaffold from electrospun hydroxyethyl cellulose (HEC) functionalized with bone-like calcium phosphate (CaP). The HEC/PVA nanofibers were fabricated by electrospinning and mineralized by incubating in 10× simulated body fluid (SBF) for different period of times. After 24 h of incubation, the nanofibers were uniformly coated by a thin layer of mineral deposit. SEM, FTIR, and FESEM-EDS analyses confirm the deposition of CaP on the nanofibers. The nanostructured biomaterial maintained its fibrous and porous structure after mineralization. The XRD results suggest that the deposited mineral phase is a mixture of calcium phosphate hydrate and apatite. The mechanical properties of CaP coated scaffolds show similar tensile strength and elastic modulus with that of trabecular and proximal femoral bones. The cytocompatibility of the CaP coated HEC/PVA scaffolds were evaluated using human osteosarcoma cells. The CaP coated HEC/PVA scaffolds support cellular attachment and proliferation of osteosarcoma cells and will be a promising candidate for bone tissue engineering. Royal Society of Chemistry 2015 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6255/1/Electrospun%20Hydroxyethyl%20Cellulose%20Nanofibers%20Functionalized%20With%20Calcium%20Phosphate%20Coating%20For%20Bone%20Tissue%20Engineering.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/6255/7/fist-2015-fathima-electrospun%20hydroxyethyl%20cellulose%20nanofibers.pdf Sugandha, Chahal and Jahir Hussain, Fathima Shahitha and Anuj, Kumar and M. M., Yusoff and Mohamad Syaiful Bahari, Abdull Rasad (2015) Electrospun Hydroxyethyl Cellulose Nanofibers Functionalized With Calcium Phosphate Coating for Bone Tissue Engineering. RSC Advances, 5 (37). pp. 29497-29504. ISSN 2046-2069 http://dx.doi.org/10.1039/C4RA17087C DOI: 10.1039/C4RA17087C
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Sugandha, Chahal Jahir Hussain, Fathima Shahitha Anuj, Kumar M. M., Yusoff Mohamad Syaiful Bahari, Abdull Rasad Electrospun Hydroxyethyl Cellulose Nanofibers Functionalized With Calcium Phosphate Coating for Bone Tissue Engineering
description	The aim of this study is to develop a facile and efficient scaffold from electrospun hydroxyethyl cellulose (HEC) functionalized with bone-like calcium phosphate (CaP). The HEC/PVA nanofibers were fabricated by electrospinning and mineralized by incubating in 10× simulated body fluid (SBF) for different period of times. After 24 h of incubation, the nanofibers were uniformly coated by a thin layer of mineral deposit. SEM, FTIR, and FESEM-EDS analyses confirm the deposition of CaP on the nanofibers. The nanostructured biomaterial maintained its fibrous and porous structure after mineralization. The XRD results suggest that the deposited mineral phase is a mixture of calcium phosphate hydrate and apatite. The mechanical properties of CaP coated scaffolds show similar tensile strength and elastic modulus with that of trabecular and proximal femoral bones. The cytocompatibility of the CaP coated HEC/PVA scaffolds were evaluated using human osteosarcoma cells. The CaP coated HEC/PVA scaffolds support cellular attachment and proliferation of osteosarcoma cells and will be a promising candidate for bone tissue engineering.
format	Article
author	Sugandha, Chahal Jahir Hussain, Fathima Shahitha Anuj, Kumar M. M., Yusoff Mohamad Syaiful Bahari, Abdull Rasad
author_facet	Sugandha, Chahal Jahir Hussain, Fathima Shahitha Anuj, Kumar M. M., Yusoff Mohamad Syaiful Bahari, Abdull Rasad
author_sort	Sugandha, Chahal
title	Electrospun Hydroxyethyl Cellulose Nanofibers Functionalized With Calcium Phosphate Coating for Bone Tissue Engineering
title_short	Electrospun Hydroxyethyl Cellulose Nanofibers Functionalized With Calcium Phosphate Coating for Bone Tissue Engineering
title_full	Electrospun Hydroxyethyl Cellulose Nanofibers Functionalized With Calcium Phosphate Coating for Bone Tissue Engineering
title_fullStr	Electrospun Hydroxyethyl Cellulose Nanofibers Functionalized With Calcium Phosphate Coating for Bone Tissue Engineering
title_full_unstemmed	Electrospun Hydroxyethyl Cellulose Nanofibers Functionalized With Calcium Phosphate Coating for Bone Tissue Engineering
title_sort	electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering
publisher	Royal Society of Chemistry
publishDate	2015
url	http://umpir.ump.edu.my/id/eprint/6255/ http://umpir.ump.edu.my/id/eprint/6255/ http://umpir.ump.edu.my/id/eprint/6255/ http://umpir.ump.edu.my/id/eprint/6255/1/Electrospun%20Hydroxyethyl%20Cellulose%20Nanofibers%20Functionalized%20With%20Calcium%20Phosphate%20Coating%20For%20Bone%20Tissue%20Engineering.pdf http://umpir.ump.edu.my/id/eprint/6255/7/fist-2015-fathima-electrospun%20hydroxyethyl%20cellulose%20nanofibers.pdf
first_indexed	2023-09-18T22:01:51Z
last_indexed	2023-09-18T22:01:51Z
_version_	1777414451206553600

Electrospun Hydroxyethyl Cellulose Nanofibers Functionalized With Calcium Phosphate Coating for Bone Tissue Engineering

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