Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System
Solubility of carbamazepine co-crystal produced from cooling co-crystallization process with succinic acid as a co-crystal former is investigated in this study. Two techniques are used to determine the solubility of the co-crystal which is gravimetric and HPLC.The solubility experiment in ethanol so...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Trans Tech Publications, Switzerland
2015
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/6653/ http://umpir.ump.edu.my/id/eprint/6653/ http://umpir.ump.edu.my/id/eprint/6653/ http://umpir.ump.edu.my/id/eprint/6653/1/solubility_of_carbamazepine-succinic_co-crystal_in_ethanolic_solvent_system.pdf |
| Summary: | Solubility of carbamazepine co-crystal produced from cooling co-crystallization process with succinic acid as a co-crystal former is investigated in this study. Two techniques are used to determine the solubility of the co-crystal which is gravimetric and HPLC.The solubility experiment in ethanol solvent system were conducted at 6 different temperatures (25, 30, 35, 40, 45 and 50°c) while for succinic acid solution system were conducted at 5 different concentration ratio. Both of the system are equilibrated for 72 hours. Result from the experiment has shown that the solubility of co-crystal is depending on temperature. As the temperature increase, the solubility of co-crystal also increased, this situation meets the Second Law of Thermodynamic which heat facilitates the dissolution process by providing more energy to the system. |
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