Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System

Solubility of carbamazepine co-crystal produced from cooling co-crystallization process with succinic acid as a co-crystal former is investigated in this study. Two techniques are used to determine the solubility of the co-crystal which is gravimetric and HPLC.The solubility experiment in ethanol so...

Full description

Bibliographic Details
Main Authors:	Noor Ashila, Ramle, Syarifah, Abd Rahim, El-Hadad, Omar, Nornizar, Anuar
Format:	Article
Language:	English
Published:	Trans Tech Publications, Switzerland 2015
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/6653/ http://umpir.ump.edu.my/id/eprint/6653/ http://umpir.ump.edu.my/id/eprint/6653/ http://umpir.ump.edu.my/id/eprint/6653/1/solubility_of_carbamazepine-succinic_co-crystal_in_ethanolic_solvent_system.pdf

id	ump-6653
recordtype	eprints
spelling	ump-66532017-09-29T07:57:10Z http://umpir.ump.edu.my/id/eprint/6653/ Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System Noor Ashila, Ramle Syarifah, Abd Rahim El-Hadad, Omar Nornizar, Anuar TP Chemical technology Solubility of carbamazepine co-crystal produced from cooling co-crystallization process with succinic acid as a co-crystal former is investigated in this study. Two techniques are used to determine the solubility of the co-crystal which is gravimetric and HPLC.The solubility experiment in ethanol solvent system were conducted at 6 different temperatures (25, 30, 35, 40, 45 and 50°c) while for succinic acid solution system were conducted at 5 different concentration ratio. Both of the system are equilibrated for 72 hours. Result from the experiment has shown that the solubility of co-crystal is depending on temperature. As the temperature increase, the solubility of co-crystal also increased, this situation meets the Second Law of Thermodynamic which heat facilitates the dissolution process by providing more energy to the system. Trans Tech Publications, Switzerland 2015 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6653/1/solubility_of_carbamazepine-succinic_co-crystal_in_ethanolic_solvent_system.pdf Noor Ashila, Ramle and Syarifah, Abd Rahim and El-Hadad, Omar and Nornizar, Anuar (2015) Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System. Advanced Materials Research, 1113. pp. 434-439. ISSN 1022-6680 (print), 1662-8985 (online) https://www.scientific.net/AMR.1113.434 doi: 10.4028/www.scientific.net/AMR.1113.434
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Noor Ashila, Ramle Syarifah, Abd Rahim El-Hadad, Omar Nornizar, Anuar Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System
description	Solubility of carbamazepine co-crystal produced from cooling co-crystallization process with succinic acid as a co-crystal former is investigated in this study. Two techniques are used to determine the solubility of the co-crystal which is gravimetric and HPLC.The solubility experiment in ethanol solvent system were conducted at 6 different temperatures (25, 30, 35, 40, 45 and 50°c) while for succinic acid solution system were conducted at 5 different concentration ratio. Both of the system are equilibrated for 72 hours. Result from the experiment has shown that the solubility of co-crystal is depending on temperature. As the temperature increase, the solubility of co-crystal also increased, this situation meets the Second Law of Thermodynamic which heat facilitates the dissolution process by providing more energy to the system.
format	Article
author	Noor Ashila, Ramle Syarifah, Abd Rahim El-Hadad, Omar Nornizar, Anuar
author_facet	Noor Ashila, Ramle Syarifah, Abd Rahim El-Hadad, Omar Nornizar, Anuar
author_sort	Noor Ashila, Ramle
title	Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System
title_short	Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System
title_full	Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System
title_fullStr	Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System
title_full_unstemmed	Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System
title_sort	solubility of carbamazepine-succinic co-crystal in ethanolic solvent system
publisher	Trans Tech Publications, Switzerland
publishDate	2015
url	http://umpir.ump.edu.my/id/eprint/6653/ http://umpir.ump.edu.my/id/eprint/6653/ http://umpir.ump.edu.my/id/eprint/6653/ http://umpir.ump.edu.my/id/eprint/6653/1/solubility_of_carbamazepine-succinic_co-crystal_in_ethanolic_solvent_system.pdf
first_indexed	2023-09-18T22:02:37Z
last_indexed	2023-09-18T22:02:37Z
_version_	1777414499605676032

Solubility of Carbamazepine-Succinic Co-Crystal in Ethanolic Solvent System

Similar Items