Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal
In this study the effect of the heating/cooling rate of various CBZ-SAC mixture in ethanol was investigated in order to deduce the metastable zone width (MSZW) and the nucleation order. Nivlt' s equation involving the maximum temperature difference ATm between dissolution and crystallization t...
| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/6744/ http://umpir.ump.edu.my/id/eprint/6744/1/Nucleation_Kinetics_of_Carbamazepine-Saccharin_%28CBZ-SAC%29_Co-Crystal.PDF |
| Summary: | In this study the effect of the heating/cooling rate of various CBZ-SAC mixture in ethanol was investigated in order to deduce the metastable zone width (MSZW) and the
nucleation order. Nivlt' s equation involving the maximum temperature difference ATm between dissolution and crystallization temperatures of CBZ-SAC co-crystals with the heating/cooling rate r was applied for the study of nucleation kinetics by the polythermal method. A step towards the determination of dissolution temperature of the crystals has been improved. The results showed that dissolution temperature for CBZ-SAC co-crystal mixture
increased with the increase in heating rate, CBZ-concentration and the ratio of SAC to CBZ in ethanol solution. The analysis revealed that a nucleation order for CBZ-SAC co-crystals increases with the SAC to CBZ ratio and is in the range of 1.58 to 6.31. |
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