Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal
In this study the effect of the heating/cooling rate of various CBZ-SAC mixture in ethanol was investigated in order to deduce the metastable zone width (MSZW) and the nucleation order. Nivlt' s equation involving the maximum temperature difference ATm between dissolution and crystallization t...
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2014
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| Online Access: | http://umpir.ump.edu.my/id/eprint/6744/ http://umpir.ump.edu.my/id/eprint/6744/1/Nucleation_Kinetics_of_Carbamazepine-Saccharin_%28CBZ-SAC%29_Co-Crystal.PDF |
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ump-67442015-03-03T09:32:25Z http://umpir.ump.edu.my/id/eprint/6744/ Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal Khairool Azizul, Mohammad Syarifah, Abd Rahim Mohd Rushdi, Abu Bakar TP Chemical technology In this study the effect of the heating/cooling rate of various CBZ-SAC mixture in ethanol was investigated in order to deduce the metastable zone width (MSZW) and the nucleation order. Nivlt' s equation involving the maximum temperature difference ATm between dissolution and crystallization temperatures of CBZ-SAC co-crystals with the heating/cooling rate r was applied for the study of nucleation kinetics by the polythermal method. A step towards the determination of dissolution temperature of the crystals has been improved. The results showed that dissolution temperature for CBZ-SAC co-crystal mixture increased with the increase in heating rate, CBZ-concentration and the ratio of SAC to CBZ in ethanol solution. The analysis revealed that a nucleation order for CBZ-SAC co-crystals increases with the SAC to CBZ ratio and is in the range of 1.58 to 6.31. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6744/1/Nucleation_Kinetics_of_Carbamazepine-Saccharin_%28CBZ-SAC%29_Co-Crystal.PDF Khairool Azizul, Mohammad and Syarifah, Abd Rahim and Mohd Rushdi, Abu Bakar (2014) Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal. In: 2nd International Conference on Global Sustainability and Chemical Engineering (ICDSCE) 2014, 20-22 August 2014 , Kuala Lumpur. . |
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Digital Repository |
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Local University |
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Universiti Malaysia Pahang |
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UMP Institutional Repository |
| collection |
Online Access |
| language |
English |
| topic |
TP Chemical technology |
| spellingShingle |
TP Chemical technology Khairool Azizul, Mohammad Syarifah, Abd Rahim Mohd Rushdi, Abu Bakar Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal |
| description |
In this study the effect of the heating/cooling rate of various CBZ-SAC mixture in ethanol was investigated in order to deduce the metastable zone width (MSZW) and the
nucleation order. Nivlt' s equation involving the maximum temperature difference ATm between dissolution and crystallization temperatures of CBZ-SAC co-crystals with the heating/cooling rate r was applied for the study of nucleation kinetics by the polythermal method. A step towards the determination of dissolution temperature of the crystals has been improved. The results showed that dissolution temperature for CBZ-SAC co-crystal mixture
increased with the increase in heating rate, CBZ-concentration and the ratio of SAC to CBZ in ethanol solution. The analysis revealed that a nucleation order for CBZ-SAC co-crystals increases with the SAC to CBZ ratio and is in the range of 1.58 to 6.31. |
| format |
Conference or Workshop Item |
| author |
Khairool Azizul, Mohammad Syarifah, Abd Rahim Mohd Rushdi, Abu Bakar |
| author_facet |
Khairool Azizul, Mohammad Syarifah, Abd Rahim Mohd Rushdi, Abu Bakar |
| author_sort |
Khairool Azizul, Mohammad |
| title |
Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal |
| title_short |
Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal |
| title_full |
Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal |
| title_fullStr |
Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal |
| title_full_unstemmed |
Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-Crystal |
| title_sort |
nucleation kinetics of carbamazepine-saccharin (cbz-sac) co-crystal |
| publishDate |
2014 |
| url |
http://umpir.ump.edu.my/id/eprint/6744/ http://umpir.ump.edu.my/id/eprint/6744/1/Nucleation_Kinetics_of_Carbamazepine-Saccharin_%28CBZ-SAC%29_Co-Crystal.PDF |
| first_indexed |
2023-09-18T22:02:46Z |
| last_indexed |
2023-09-18T22:02:46Z |
| _version_ |
1777414509015597056 |