Solid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal

A research was conducted on the solid phase transformation and stability of carbamazepine-saccharin co-crystal. Pharmaceutical co-crystal is one of the potential methods for improving the bioavailibity of drugs with low aqueous solubility. Thus, the purpose of this research is to determine the stabl...

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Main Author:	Nur Aida, Zakiriah
Format:	Undergraduates Project Papers
Language:	English
Published:	2013
Subjects:	TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/7118/ http://umpir.ump.edu.my/id/eprint/7118/ http://umpir.ump.edu.my/id/eprint/7118/1/Solid_phase_transformation.pdf

id	ump-7118
recordtype	eprints
spelling	ump-71182015-03-03T09:34:22Z http://umpir.ump.edu.my/id/eprint/7118/ Solid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal Nur Aida, Zakiriah TP Chemical technology A research was conducted on the solid phase transformation and stability of carbamazepine-saccharin co-crystal. Pharmaceutical co-crystal is one of the potential methods for improving the bioavailibity of drugs with low aqueous solubility. Thus, the purpose of this research is to determine the stable region of carbamazepine-saccharin (CBZ-SAC) co-crystal formation by using solution based method. In this method, three technique are used which are cooling crystallization, solvent evaporation and slurry, to prepare the chemical and use ethanol as a solvent. Different mol ratio of CBZ and SAC are being tested, in order to study CBZ-SAC cocrystal formation. Physical characterizations of the co-crystal are being characterized by differential scanning calorimetry and research microscope. Overall as the concentration of saccharin increase the melting point increase and will lead to poor solubility but mostly the melting point of co-crystal resulting in lower melting point. From this research can be concluded that CBZ-SAC co-crystal can form two forms which are plate-like and needle like. Varying the mol of carbamazepine and used different solvents could be used for further studies to see the difference trending. 2013 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/7118/1/Solid_phase_transformation.pdf Nur Aida, Zakiriah (2013) Solid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang. http://iportal.ump.edu.my/lib/item?id=chamo:75737&theme=UMP2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Nur Aida, Zakiriah Solid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal
description	A research was conducted on the solid phase transformation and stability of carbamazepine-saccharin co-crystal. Pharmaceutical co-crystal is one of the potential methods for improving the bioavailibity of drugs with low aqueous solubility. Thus, the purpose of this research is to determine the stable region of carbamazepine-saccharin (CBZ-SAC) co-crystal formation by using solution based method. In this method, three technique are used which are cooling crystallization, solvent evaporation and slurry, to prepare the chemical and use ethanol as a solvent. Different mol ratio of CBZ and SAC are being tested, in order to study CBZ-SAC cocrystal formation. Physical characterizations of the co-crystal are being characterized by differential scanning calorimetry and research microscope. Overall as the concentration of saccharin increase the melting point increase and will lead to poor solubility but mostly the melting point of co-crystal resulting in lower melting point. From this research can be concluded that CBZ-SAC co-crystal can form two forms which are plate-like and needle like. Varying the mol of carbamazepine and used different solvents could be used for further studies to see the difference trending.
format	Undergraduates Project Papers
author	Nur Aida, Zakiriah
author_facet	Nur Aida, Zakiriah
author_sort	Nur Aida, Zakiriah
title	Solid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal
title_short	Solid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal
title_full	Solid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal
title_fullStr	Solid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal
title_full_unstemmed	Solid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal
title_sort	solid phase transformation of carbamazepine-saccharin (cbz-sac) co-crystal
publishDate	2013
url	http://umpir.ump.edu.my/id/eprint/7118/ http://umpir.ump.edu.my/id/eprint/7118/ http://umpir.ump.edu.my/id/eprint/7118/1/Solid_phase_transformation.pdf
first_indexed	2023-09-18T22:03:30Z
last_indexed	2023-09-18T22:03:30Z
_version_	1777414554353926144

Solid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal

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