Nanobeads formation for anticancer drug release controlled by electrospinning

Anticancer drug nowadays have become one of the most important industry in the world. In order to improve drug delivery, the used of nanoparticles is the main purpose for this research study. The objectives for this study are to investigate the morphology of nanoparticles produced based on different...

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Main Author:	Muhammad Syafiq, Abd Rahman
Format:	Undergraduates Project Papers
Language:	English
Published:	2013
Subjects:	RC Internal medicine
Online Access:	http://umpir.ump.edu.my/id/eprint/7223/ http://umpir.ump.edu.my/id/eprint/7223/ http://umpir.ump.edu.my/id/eprint/7223/1/Nanobeads_formation_for_anticancer_drug_release_controlled.pdf

id	ump-7223
recordtype	eprints
spelling	ump-72232015-03-03T09:34:50Z http://umpir.ump.edu.my/id/eprint/7223/ Nanobeads formation for anticancer drug release controlled by electrospinning Muhammad Syafiq, Abd Rahman RC Internal medicine Anticancer drug nowadays have become one of the most important industry in the world. In order to improve drug delivery, the used of nanoparticles is the main purpose for this research study. The objectives for this study are to investigate the morphology of nanoparticles produced based on different molecular weight of and concentration of Polyethylene Oxide (PEO). In this research, a very high molecular weight (MR) PEO is used as the core polymer. Two types of PEO used are with 400 000 MW and 900 000 MW. There are two types of solvents used that are distilled water and ethanol. Whey protein is used because it containing Cysteine, one of the sulphur-containing amino acid and has same properties as anticancer drug. Henceforth, whey protein is used because it is easily to purchase and cheaper. PEO acts as shell that encapsulated the drug. There are two main processes for the nanoparticles preparation that are solution preparation and electrospinning. Four types of solution are prepared; PEO with water, PEO with Ethanol, PEO with protein, and PEO with protein and ethanol. All samples are prepared till 10 mL and 20 mL and then go through the electrospinning about 5 hours. After electrospinnig the samples will be analyzed under Field Emission Scanning Electron Microscopy (FESEM) to observe the morphology of nanoparticles and Energy Dispersive X- Ray (EDX) for sulphur determination. The resulted obtained showed the lower the viscosity, the more the formation of nanobeads. Lower molecular weight also affects the nanobeads formation as lower molecular weight is more beads than higher molecular weight. 2013 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/7223/1/Nanobeads_formation_for_anticancer_drug_release_controlled.pdf Muhammad Syafiq, Abd Rahman (2013) Nanobeads formation for anticancer drug release controlled by electrospinning. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang. http://iportal.ump.edu.my/lib/item?id=chamo:76090&theme=UMP2
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Muhammad Syafiq, Abd Rahman Nanobeads formation for anticancer drug release controlled by electrospinning
description	Anticancer drug nowadays have become one of the most important industry in the world. In order to improve drug delivery, the used of nanoparticles is the main purpose for this research study. The objectives for this study are to investigate the morphology of nanoparticles produced based on different molecular weight of and concentration of Polyethylene Oxide (PEO). In this research, a very high molecular weight (MR) PEO is used as the core polymer. Two types of PEO used are with 400 000 MW and 900 000 MW. There are two types of solvents used that are distilled water and ethanol. Whey protein is used because it containing Cysteine, one of the sulphur-containing amino acid and has same properties as anticancer drug. Henceforth, whey protein is used because it is easily to purchase and cheaper. PEO acts as shell that encapsulated the drug. There are two main processes for the nanoparticles preparation that are solution preparation and electrospinning. Four types of solution are prepared; PEO with water, PEO with Ethanol, PEO with protein, and PEO with protein and ethanol. All samples are prepared till 10 mL and 20 mL and then go through the electrospinning about 5 hours. After electrospinnig the samples will be analyzed under Field Emission Scanning Electron Microscopy (FESEM) to observe the morphology of nanoparticles and Energy Dispersive X- Ray (EDX) for sulphur determination. The resulted obtained showed the lower the viscosity, the more the formation of nanobeads. Lower molecular weight also affects the nanobeads formation as lower molecular weight is more beads than higher molecular weight.
format	Undergraduates Project Papers
author	Muhammad Syafiq, Abd Rahman
author_facet	Muhammad Syafiq, Abd Rahman
author_sort	Muhammad Syafiq, Abd Rahman
title	Nanobeads formation for anticancer drug release controlled by electrospinning
title_short	Nanobeads formation for anticancer drug release controlled by electrospinning
title_full	Nanobeads formation for anticancer drug release controlled by electrospinning
title_fullStr	Nanobeads formation for anticancer drug release controlled by electrospinning
title_full_unstemmed	Nanobeads formation for anticancer drug release controlled by electrospinning
title_sort	nanobeads formation for anticancer drug release controlled by electrospinning
publishDate	2013
url	http://umpir.ump.edu.my/id/eprint/7223/ http://umpir.ump.edu.my/id/eprint/7223/ http://umpir.ump.edu.my/id/eprint/7223/1/Nanobeads_formation_for_anticancer_drug_release_controlled.pdf
first_indexed	2023-09-18T22:03:44Z
last_indexed	2023-09-18T22:03:44Z
_version_	1777414569732341760

Nanobeads formation for anticancer drug release controlled by electrospinning

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