Synthesis, Characterization and Urease Inhibiting Derivatives of 5-(3,4-Methylenedioxyphenyl)-1,3,4-Oxadiazol-2-thiol

In the present work, the urease inhibition activity of 1,3,4-oxadiazole bearing molecules was evaluated and were found to be potential inhibitors. 3,4-(Methylenedioxy)benzoic acid (1) was employed to synthesize 5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazol-2-thiol (4) via a series of steps. It was fu...

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Main Authors:	Akhtar, Muhammad Nadeem, Rehman, Aziz-ur, Siddiqa, Asia, Abbasi, Muhammad Athar, Rasool, Shahid, Lodhi, Muhammad A., Nafeesa, Khadija, Khan, Ajmal
Format:	Article
Language:	English English
Published:	Asian J. Chem 2014
Subjects:	QD Chemistry
Online Access:	http://umpir.ump.edu.my/id/eprint/7992/ http://umpir.ump.edu.my/id/eprint/7992/ http://umpir.ump.edu.my/id/eprint/7992/ http://umpir.ump.edu.my/id/eprint/7992/1/fist-2014-nadeem-Synthesis%2C_Characterization.pdf http://umpir.ump.edu.my/id/eprint/7992/4/Synthesis%2C%20Characterization%20and%20Urease%20Inhibiting%20Derivatives%20of%205-%283%2C4%20Methylenedioxyphenyl%29-1%2C3%2C4-Oxadiazol-2-thiol.pdf

id	ump-7992
recordtype	eprints
spelling	ump-79922018-04-18T04:11:43Z http://umpir.ump.edu.my/id/eprint/7992/ Synthesis, Characterization and Urease Inhibiting Derivatives of 5-(3,4-Methylenedioxyphenyl)-1,3,4-Oxadiazol-2-thiol Akhtar, Muhammad Nadeem Rehman, Aziz-ur Siddiqa, Asia Abbasi, Muhammad Athar Rasool, Shahid Lodhi, Muhammad A. Nafeesa, Khadija Khan, Ajmal QD Chemistry In the present work, the urease inhibition activity of 1,3,4-oxadiazole bearing molecules was evaluated and were found to be potential inhibitors. 3,4-(Methylenedioxy)benzoic acid (1) was employed to synthesize 5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazol-2-thiol (4) via a series of steps. It was further stepped to yield S-substituted-5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazole derivatives (6a-h) on reaction with alkyl/aralkyl halides (5a-h) in DMF using LiH as an activator. All the synthesized compounds were well supported by IR, 1H NMR and EIMS spectral analysis. The enzyme inhibition activity against urease enzyme showed these molecules as potent inhibitors of this enzyme. - See more at: http://www.asianjournalofchemistry.co.in/(X(1))/user/journal/viewarticle.aspx?ArticleID=26_16_15#sthash.Y6WNhFR2.dpuf Asian J. Chem 2014 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/7992/1/fist-2014-nadeem-Synthesis%2C_Characterization.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/7992/4/Synthesis%2C%20Characterization%20and%20Urease%20Inhibiting%20Derivatives%20of%205-%283%2C4%20Methylenedioxyphenyl%29-1%2C3%2C4-Oxadiazol-2-thiol.pdf Akhtar, Muhammad Nadeem and Rehman, Aziz-ur and Siddiqa, Asia and Abbasi, Muhammad Athar and Rasool, Shahid and Lodhi, Muhammad A. and Nafeesa, Khadija and Khan, Ajmal (2014) Synthesis, Characterization and Urease Inhibiting Derivatives of 5-(3,4-Methylenedioxyphenyl)-1,3,4-Oxadiazol-2-thiol. Asian Journal of Chemistry , 26 (15). pp. 4605-4609. ISSN 0970-7077 http://dx.doi.org/10.14233/ajchem.2014.16132 DOI: 10.14233/ajchem.2014.16132
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Akhtar, Muhammad Nadeem Rehman, Aziz-ur Siddiqa, Asia Abbasi, Muhammad Athar Rasool, Shahid Lodhi, Muhammad A. Nafeesa, Khadija Khan, Ajmal Synthesis, Characterization and Urease Inhibiting Derivatives of 5-(3,4-Methylenedioxyphenyl)-1,3,4-Oxadiazol-2-thiol
description	In the present work, the urease inhibition activity of 1,3,4-oxadiazole bearing molecules was evaluated and were found to be potential inhibitors. 3,4-(Methylenedioxy)benzoic acid (1) was employed to synthesize 5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazol-2-thiol (4) via a series of steps. It was further stepped to yield S-substituted-5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazole derivatives (6a-h) on reaction with alkyl/aralkyl halides (5a-h) in DMF using LiH as an activator. All the synthesized compounds were well supported by IR, 1H NMR and EIMS spectral analysis. The enzyme inhibition activity against urease enzyme showed these molecules as potent inhibitors of this enzyme. - See more at: http://www.asianjournalofchemistry.co.in/(X(1))/user/journal/viewarticle.aspx?ArticleID=26_16_15#sthash.Y6WNhFR2.dpuf
format	Article
author	Akhtar, Muhammad Nadeem Rehman, Aziz-ur Siddiqa, Asia Abbasi, Muhammad Athar Rasool, Shahid Lodhi, Muhammad A. Nafeesa, Khadija Khan, Ajmal
author_facet	Akhtar, Muhammad Nadeem Rehman, Aziz-ur Siddiqa, Asia Abbasi, Muhammad Athar Rasool, Shahid Lodhi, Muhammad A. Nafeesa, Khadija Khan, Ajmal
author_sort	Akhtar, Muhammad Nadeem
title	Synthesis, Characterization and Urease Inhibiting Derivatives of 5-(3,4-Methylenedioxyphenyl)-1,3,4-Oxadiazol-2-thiol
title_short	Synthesis, Characterization and Urease Inhibiting Derivatives of 5-(3,4-Methylenedioxyphenyl)-1,3,4-Oxadiazol-2-thiol
title_full	Synthesis, Characterization and Urease Inhibiting Derivatives of 5-(3,4-Methylenedioxyphenyl)-1,3,4-Oxadiazol-2-thiol
title_fullStr	Synthesis, Characterization and Urease Inhibiting Derivatives of 5-(3,4-Methylenedioxyphenyl)-1,3,4-Oxadiazol-2-thiol
title_full_unstemmed	Synthesis, Characterization and Urease Inhibiting Derivatives of 5-(3,4-Methylenedioxyphenyl)-1,3,4-Oxadiazol-2-thiol
title_sort	synthesis, characterization and urease inhibiting derivatives of 5-(3,4-methylenedioxyphenyl)-1,3,4-oxadiazol-2-thiol
publisher	Asian J. Chem
publishDate	2014
url	http://umpir.ump.edu.my/id/eprint/7992/ http://umpir.ump.edu.my/id/eprint/7992/ http://umpir.ump.edu.my/id/eprint/7992/ http://umpir.ump.edu.my/id/eprint/7992/1/fist-2014-nadeem-Synthesis%2C_Characterization.pdf http://umpir.ump.edu.my/id/eprint/7992/4/Synthesis%2C%20Characterization%20and%20Urease%20Inhibiting%20Derivatives%20of%205-%283%2C4%20Methylenedioxyphenyl%29-1%2C3%2C4-Oxadiazol-2-thiol.pdf
first_indexed	2023-09-18T22:05:13Z
last_indexed	2023-09-18T22:05:13Z
_version_	1777414662560677888

Synthesis, Characterization and Urease Inhibiting Derivatives of 5-(3,4-Methylenedioxyphenyl)-1,3,4-Oxadiazol-2-thiol

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