Antihypertensive Activity and Phytochemicals Analysis of Chassalia curviflora Extracts

The objectives of this study are to determine the antihypertensive activities of leaves and flower of Chassalia curviflora and compare the potential between two different extraction methods which are hot water and methanol extract. The biuret protein assay was conducted to determine the protein prot...

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Main Authors:	Wan Nur Hazirah, W. Kadir, Nor Adila, Mhd Omar
Format:	Article
Language:	English English
Published:	2014
Subjects:	Q Science (General)
Online Access:	http://umpir.ump.edu.my/id/eprint/8277/ http://umpir.ump.edu.my/id/eprint/8277/1/Antihypertensive_Activity_and_Phytochemicals_Analysis_of_Chassalia_curviflora_Extracts.pdf http://umpir.ump.edu.my/id/eprint/8277/4/Antihypertensive%20Activity%20and%20Phytochemicals%20Analysis%20of%20Chassalia%20curviflora%20Extracts.pdf

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recordtype	eprints
spelling	ump-82772018-06-28T08:31:45Z http://umpir.ump.edu.my/id/eprint/8277/ Antihypertensive Activity and Phytochemicals Analysis of Chassalia curviflora Extracts Wan Nur Hazirah, W. Kadir Nor Adila, Mhd Omar Q Science (General) The objectives of this study are to determine the antihypertensive activities of leaves and flower of Chassalia curviflora and compare the potential between two different extraction methods which are hot water and methanol extract. The biuret protein assay was conducted to determine the protein protein concentration in samples. The phytochemical in leaves and flower extracts of C. curviflora were analyzed by using GC-MS. The result of protein concentration in C. curviflora flower was higher compared to leaves extract of 0.6648 mg/ml and 0.5431 mg/ml, respectively. The hot water extract of C. curviflora flower showed the highest antihypertensive activity with the percentage of ACE inhibitory activity of 95.50 ± 0.06% with IC50 value of 3.71 μg/ml. The 10 highest peak area (%) of phytochemical in all samples were: bis(2-ethylhexyl) ester (34.64 %), Cyclotrisiloxane, hexamethyl- (31.14 %), (Phenylthio)acetic acid, 1-adamantylmethyl ester (30.90 %), Hexanedioic acid, Cyclononasiloxane, octadecamethyl- (18.357 %), Oleic Acid (16.56 %), n-Hexadecanoic acid (15.23 % and 14.15 %), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6- methyl- (16.43 % and 12.98 %) and Trichloromethane (11.03 %). In conclusion, both of leaves and flower of C. curviflora have a potential as antihypertensive agent. 2014 Article PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/8277/1/Antihypertensive_Activity_and_Phytochemicals_Analysis_of_Chassalia_curviflora_Extracts.pdf application/pdf en http://umpir.ump.edu.my/id/eprint/8277/4/Antihypertensive%20Activity%20and%20Phytochemicals%20Analysis%20of%20Chassalia%20curviflora%20Extracts.pdf Wan Nur Hazirah, W. Kadir and Nor Adila, Mhd Omar (2014) Antihypertensive Activity and Phytochemicals Analysis of Chassalia curviflora Extracts. International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS), 2 (1). pp. 163-174. ISSN 2348 – 0343
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Malaysia Pahang
building	UMP Institutional Repository
collection	Online Access
language	English English
topic	Q Science (General)
spellingShingle	Q Science (General) Wan Nur Hazirah, W. Kadir Nor Adila, Mhd Omar Antihypertensive Activity and Phytochemicals Analysis of Chassalia curviflora Extracts
description	The objectives of this study are to determine the antihypertensive activities of leaves and flower of Chassalia curviflora and compare the potential between two different extraction methods which are hot water and methanol extract. The biuret protein assay was conducted to determine the protein protein concentration in samples. The phytochemical in leaves and flower extracts of C. curviflora were analyzed by using GC-MS. The result of protein concentration in C. curviflora flower was higher compared to leaves extract of 0.6648 mg/ml and 0.5431 mg/ml, respectively. The hot water extract of C. curviflora flower showed the highest antihypertensive activity with the percentage of ACE inhibitory activity of 95.50 ± 0.06% with IC50 value of 3.71 μg/ml. The 10 highest peak area (%) of phytochemical in all samples were: bis(2-ethylhexyl) ester (34.64 %), Cyclotrisiloxane, hexamethyl- (31.14 %), (Phenylthio)acetic acid, 1-adamantylmethyl ester (30.90 %), Hexanedioic acid, Cyclononasiloxane, octadecamethyl- (18.357 %), Oleic Acid (16.56 %), n-Hexadecanoic acid (15.23 % and 14.15 %), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6- methyl- (16.43 % and 12.98 %) and Trichloromethane (11.03 %). In conclusion, both of leaves and flower of C. curviflora have a potential as antihypertensive agent.
format	Article
author	Wan Nur Hazirah, W. Kadir Nor Adila, Mhd Omar
author_facet	Wan Nur Hazirah, W. Kadir Nor Adila, Mhd Omar
author_sort	Wan Nur Hazirah, W. Kadir
title	Antihypertensive Activity and Phytochemicals Analysis of Chassalia curviflora Extracts
title_short	Antihypertensive Activity and Phytochemicals Analysis of Chassalia curviflora Extracts
title_full	Antihypertensive Activity and Phytochemicals Analysis of Chassalia curviflora Extracts
title_fullStr	Antihypertensive Activity and Phytochemicals Analysis of Chassalia curviflora Extracts
title_full_unstemmed	Antihypertensive Activity and Phytochemicals Analysis of Chassalia curviflora Extracts
title_sort	antihypertensive activity and phytochemicals analysis of chassalia curviflora extracts
publishDate	2014
url	http://umpir.ump.edu.my/id/eprint/8277/ http://umpir.ump.edu.my/id/eprint/8277/1/Antihypertensive_Activity_and_Phytochemicals_Analysis_of_Chassalia_curviflora_Extracts.pdf http://umpir.ump.edu.my/id/eprint/8277/4/Antihypertensive%20Activity%20and%20Phytochemicals%20Analysis%20of%20Chassalia%20curviflora%20Extracts.pdf
first_indexed	2023-09-18T22:05:40Z
last_indexed	2023-09-18T22:05:40Z
_version_	1777414691469918208

Antihypertensive Activity and Phytochemicals Analysis of Chassalia curviflora Extracts

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