Screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method
A research was conducted on the screening of carbamazepine-ibuprofen co-crystal formation using stoichiometric method via co-grinding and solvent evaporation. Pharmaceutical co-crystals formation have been proven useful in enhancing the solubility, dissolution rate, stability, and bioavailability of...
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| Format: | Undergraduates Project Papers |
| Language: | English |
| Published: |
2014
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| Online Access: | http://umpir.ump.edu.my/id/eprint/9012/ http://umpir.ump.edu.my/id/eprint/9012/ http://umpir.ump.edu.my/id/eprint/9012/1/CD8600%20%40%2028.pdf |
| Summary: | A research was conducted on the screening of carbamazepine-ibuprofen co-crystal formation using stoichiometric method via co-grinding and solvent evaporation. Pharmaceutical co-crystals formation have been proven useful in enhancing the solubility, dissolution rate, stability, and bioavailability of APIs and recognized as the promising alternative to improve APIs properties. Thus, the purpose of this research is to determine the co-crystal formation of carbamazepine-ibuprofen (CBZ-IBU) using stoichiometric methods. In this method, two techniques are used which are solvent evaporation and co-grinding by using ethanol, acetonitrile, ethyl acetate, propanol and formic acid as a solvent. Then, the produced crystal was characterized using differential scanning calorimetry (DSC) and optical microscopy. From this research, it is shown the morphology of the crystals obtained shows prismatic blade like (isometric) morphology indicated that these crystals refer to IBU confirmed by DSC results. The findings concluded that co-crystal was not being able to be formed via these methods of screening |
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