Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka

Sea cucumbers are marine invertebrates of the phylum of Echinodermata that have been used in Asian traditional medicine since ancient times. This study was conducted to investigate the antioxidant and cytotoxic properties of aqueous and organic extracts from two sea cucumber species, Holothuria ed...

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Main Authors:	Althunibat, Osama Yousef, Hashim, Ridzwan, Bakhtiar, M. Taher, Daud, Jamaluddin, Arief Ichwan, Solachuddin Jauhari, Qaralleh, Haitham
Format:	Article
Language:	English
Published:	Akadémiai Kiadó 2013
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/41753/ http://irep.iium.edu.my/41753/ http://irep.iium.edu.my/41753/1/2013-Acta_Biologica_Hungarica_.pdf

id	iium-41753
recordtype	eprints
spelling	iium-417532016-03-22T02:41:45Z http://irep.iium.edu.my/41753/ Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka Althunibat, Osama Yousef Hashim, Ridzwan Bakhtiar, M. Taher Daud, Jamaluddin Arief Ichwan, Solachuddin Jauhari Qaralleh, Haitham RS Pharmacy and materia medica Sea cucumbers are marine invertebrates of the phylum of Echinodermata that have been used in Asian traditional medicine since ancient times. This study was conducted to investigate the antioxidant and cytotoxic properties of aqueous and organic extracts from two sea cucumber species, Holothuria edulis Lesson (Holothuriidae) and Stichopus horrens Selenka (Stichopodidae). Antioxidant activities of the extracts were used to demonstrate the cytotoxic effects of the extracts against two human cancer cell lines, non-small cell lung cancer cells (A549) and esophageal cancer cells (TE1). The results showed that both aqueous and organic extracts of H. edulis were able to scavenge DPPH radical (IC50 at 2.04 mg/ml and 8.73 mg/ml, respectively). Aqueous and organic extracts of S. horrens oxidation by linoleate free radical. On the other hand, the organic extract of S. horrens exhibited the highest cytotoxic effects against A549 and TE1 cancer cells giving IC50 at 15.5 and 4.0 μg/ml, respectively. In conclusion, the present study revealed that H. edulis and S. horrens contain promising levels of antioxidant Akadémiai Kiadó 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/41753/1/2013-Acta_Biologica_Hungarica_.pdf Althunibat, Osama Yousef and Hashim, Ridzwan and Bakhtiar, M. Taher and Daud, Jamaluddin and Arief Ichwan, Solachuddin Jauhari and Qaralleh, Haitham (2013) Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka. Acta Biologica Hungarica, 64 (1). pp. 10-20. ISSN 0236-5383 (P), 1588-256X (O) http://http://www.akademiai.com/content/31076m8572135127/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Althunibat, Osama Yousef Hashim, Ridzwan Bakhtiar, M. Taher Daud, Jamaluddin Arief Ichwan, Solachuddin Jauhari Qaralleh, Haitham Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka
description	Sea cucumbers are marine invertebrates of the phylum of Echinodermata that have been used in Asian traditional medicine since ancient times. This study was conducted to investigate the antioxidant and cytotoxic properties of aqueous and organic extracts from two sea cucumber species, Holothuria edulis Lesson (Holothuriidae) and Stichopus horrens Selenka (Stichopodidae). Antioxidant activities of the extracts were used to demonstrate the cytotoxic effects of the extracts against two human cancer cell lines, non-small cell lung cancer cells (A549) and esophageal cancer cells (TE1). The results showed that both aqueous and organic extracts of H. edulis were able to scavenge DPPH radical (IC50 at 2.04 mg/ml and 8.73 mg/ml, respectively). Aqueous and organic extracts of S. horrens oxidation by linoleate free radical. On the other hand, the organic extract of S. horrens exhibited the highest cytotoxic effects against A549 and TE1 cancer cells giving IC50 at 15.5 and 4.0 μg/ml, respectively. In conclusion, the present study revealed that H. edulis and S. horrens contain promising levels of antioxidant
format	Article
author	Althunibat, Osama Yousef Hashim, Ridzwan Bakhtiar, M. Taher Daud, Jamaluddin Arief Ichwan, Solachuddin Jauhari Qaralleh, Haitham
author_facet	Althunibat, Osama Yousef Hashim, Ridzwan Bakhtiar, M. Taher Daud, Jamaluddin Arief Ichwan, Solachuddin Jauhari Qaralleh, Haitham
author_sort	Althunibat, Osama Yousef
title	Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka
title_short	Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka
title_full	Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka
title_fullStr	Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka
title_full_unstemmed	Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka
title_sort	antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka
publisher	Akadémiai Kiadó
publishDate	2013
url	http://irep.iium.edu.my/41753/ http://irep.iium.edu.my/41753/ http://irep.iium.edu.my/41753/1/2013-Acta_Biologica_Hungarica_.pdf
first_indexed	2023-09-18T20:59:42Z
last_indexed	2023-09-18T20:59:42Z
_version_	1777410540715376640

Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka

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