Renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence

Renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence

Organophosphates (OPs) pesticides are widely used in agriculture as pest control. Many people are exposed to chronic low dose of OPs through these activities. However, most of the studies on OPs mainly focused on its acute toxic effects rather than its chronic low dose effects. Limited epidemiology...

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Main Authors: Aung, Sanda, Abdullah, Nor Zamzila, Talib, Norlelawati A., Noor, Noriah Mohd, Mat Zainone, Zamzuria, Abdul Razak, Tariq
Format: Conference or Workshop Item
Language:English
English
Published: 2015
Subjects:
RB Pathology
Online Access:http://irep.iium.edu.my/44486/
http://irep.iium.edu.my/44486/
http://irep.iium.edu.my/44486/4/Abstract_book_MSPP_2015.pdf
http://irep.iium.edu.my/44486/1/MSPP_2015.pdf
id iium-44486
recordtype eprints
spelling iium-444862016-01-15T04:38:41Z http://irep.iium.edu.my/44486/ Renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence Aung, Sanda Abdullah, Nor Zamzila Talib, Norlelawati A. Noor, Noriah Mohd Mat Zainone, Zamzuria Abdul Razak, Tariq RB Pathology Organophosphates (OPs) pesticides are widely used in agriculture as pest control. Many people are exposed to chronic low dose of OPs through these activities. However, most of the studies on OPs mainly focused on its acute toxic effects rather than its chronic low dose effects. Limited epidemiology data and animal study found that there was evidence of nephrotoxicity in chronic low dose OPs exposure but the study lack of biochemical support. The aim of this study was to study the effect of chronic low dose OPs exposure on selected biochemical parameters of renal function in a rat model. 24 males Sprague-Dawley rats were randomly divided into 3 groups of 6 with Group 1 as a Control group. Group 2 and Group 3 received subcutaneous vehicle (3% dimethyl sulphoxide + 97% v/v soy oil) and 18.0 mg/kg BW chlorpyrifos (CPF) respectively every other day for 180 days. The intermittent dosing regimen is used to provide a model for the types of exposure that might be experienced by agricultural workers. Blood was analysed for urea, creatinine, glucose and advanced glycation end-products (AGEs). Urea and creatinine were significantly higher in OPs exposed group with significant correlation between urea and creatinine. OPs exposed group showed higher glucose and AGEs level than that of the control groups with significant correlation between glucose and AGEs. Significant correlations were also noted between both urea and creatinine with glucose but not with AGEs. Chronic intermittent low dose CPF exposure induces renal impairment with possible contribution from the effect of hyperglycaemia but not AGEs. Further study need to be done to explain the relevant mechanism. 2015 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/44486/4/Abstract_book_MSPP_2015.pdf application/pdf en http://irep.iium.edu.my/44486/1/MSPP_2015.pdf Aung, Sanda and Abdullah, Nor Zamzila and Talib, Norlelawati A. and Noor, Noriah Mohd and Mat Zainone, Zamzuria and Abdul Razak, Tariq (2015) Renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence. In: 29th Scientific Meeting of Malaysian Society of Pharmacology and Physiology (MSPP), 24- 25 August 2015, Setia City Convention Centre, Shah Alam, Selangor, Malaysia. http://medicine.uitm.edu.my/mspp2015/
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic RB Pathology
spellingShingle RB Pathology
Aung, Sanda
Abdullah, Nor Zamzila
Talib, Norlelawati A.
Noor, Noriah Mohd
Mat Zainone, Zamzuria
Abdul Razak, Tariq
Renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence
description Organophosphates (OPs) pesticides are widely used in agriculture as pest control. Many people are exposed to chronic low dose of OPs through these activities. However, most of the studies on OPs mainly focused on its acute toxic effects rather than its chronic low dose effects. Limited epidemiology data and animal study found that there was evidence of nephrotoxicity in chronic low dose OPs exposure but the study lack of biochemical support. The aim of this study was to study the effect of chronic low dose OPs exposure on selected biochemical parameters of renal function in a rat model. 24 males Sprague-Dawley rats were randomly divided into 3 groups of 6 with Group 1 as a Control group. Group 2 and Group 3 received subcutaneous vehicle (3% dimethyl sulphoxide + 97% v/v soy oil) and 18.0 mg/kg BW chlorpyrifos (CPF) respectively every other day for 180 days. The intermittent dosing regimen is used to provide a model for the types of exposure that might be experienced by agricultural workers. Blood was analysed for urea, creatinine, glucose and advanced glycation end-products (AGEs). Urea and creatinine were significantly higher in OPs exposed group with significant correlation between urea and creatinine. OPs exposed group showed higher glucose and AGEs level than that of the control groups with significant correlation between glucose and AGEs. Significant correlations were also noted between both urea and creatinine with glucose but not with AGEs. Chronic intermittent low dose CPF exposure induces renal impairment with possible contribution from the effect of hyperglycaemia but not AGEs. Further study need to be done to explain the relevant mechanism.
format Conference or Workshop Item
author Aung, Sanda
Abdullah, Nor Zamzila
Talib, Norlelawati A.
Noor, Noriah Mohd
Mat Zainone, Zamzuria
Abdul Razak, Tariq
author_facet Aung, Sanda
Abdullah, Nor Zamzila
Talib, Norlelawati A.
Noor, Noriah Mohd
Mat Zainone, Zamzuria
Abdul Razak, Tariq
author_sort Aung, Sanda
title Renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence
title_short Renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence
title_full Renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence
title_fullStr Renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence
title_full_unstemmed Renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence
title_sort renal impairment in intermittent chronic low dose organophosphate exposure: biochemical evidence
publishDate 2015
url http://irep.iium.edu.my/44486/
http://irep.iium.edu.my/44486/
http://irep.iium.edu.my/44486/4/Abstract_book_MSPP_2015.pdf
http://irep.iium.edu.my/44486/1/MSPP_2015.pdf
first_indexed 2023-09-18T21:03:15Z
last_indexed 2023-09-18T21:03:15Z
_version_ 1777410763725471744

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