Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy

Topoisomerases are nuclear enzymes that regulate topology of DNA by facilitating the temporary cleavage and ligation cycle of DNA. Among all forms of topoisomerases, TOP-IIA is extensively associated with cell proliferation and therefore is an important therapeutic target in diseases that involved c...

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Main Authors:	Ali, Yousaf, Abd Hamid, Shafida
Format:	Article
Language:	English English
Published:	Springer 2016
Subjects:	QD Chemistry RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/45324/ http://irep.iium.edu.my/45324/ http://irep.iium.edu.my/45324/ http://irep.iium.edu.my/45324/1/45324.pdf http://irep.iium.edu.my/45324/4/45324_Human%20topoisomerase%20II%20alpha%20as%20a%20prognostic%20biomarker%20in%20cancer%20chemotherapy_SCOPUS.pdf

id	iium-45324
recordtype	eprints
spelling	iium-453242017-07-18T06:52:40Z http://irep.iium.edu.my/45324/ Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy Ali, Yousaf Abd Hamid, Shafida QD Chemistry RM Therapeutics. Pharmacology Topoisomerases are nuclear enzymes that regulate topology of DNA by facilitating the temporary cleavage and ligation cycle of DNA. Among all forms of topoisomerases, TOP-IIA is extensively associated with cell proliferation and therefore is an important therapeutic target in diseases that involved cellular proliferation such as cancers. Nearly half of present-day antitumor regimens contain at least one prescription that act as a topoisomerase inhibitor. Generally, tumor cells show divergent expression of TOP-IIA compared to normal cells. The remarkable expression of TOP-IIA in various carcinomas provides a significant biomarker toward understanding the nature of malignancy. TOP-IIA expression and amplification studies help in diagnosing cancer and to observe the disease progression, overall survival (OS) of patients, and response to therapy. This review highlights the research output and analysis in exploring the standing of TOP-IIA in various carcinomas. As some reports show contradiction within the same field of interest, the outline of that may help to induce researchers for further investigation and clarification. To the best of our knowledge, this is the first overview briefly summarizing the prognostic feature of TOP-IIA in various types of cancer. Springer 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/45324/1/45324.pdf application/pdf en http://irep.iium.edu.my/45324/4/45324_Human%20topoisomerase%20II%20alpha%20as%20a%20prognostic%20biomarker%20in%20cancer%20chemotherapy_SCOPUS.pdf Ali, Yousaf and Abd Hamid, Shafida (2016) Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy. Tumor Biology, 37 (1). pp. 1-9. ISSN 1010-4283 E-ISSN 1423-0380 http://link.springer.com/article/10.1007%2Fs13277-015-4270-9 10.1007/s13277-015-4270-9
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry RM Therapeutics. Pharmacology
spellingShingle	QD Chemistry RM Therapeutics. Pharmacology Ali, Yousaf Abd Hamid, Shafida Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy
description	Topoisomerases are nuclear enzymes that regulate topology of DNA by facilitating the temporary cleavage and ligation cycle of DNA. Among all forms of topoisomerases, TOP-IIA is extensively associated with cell proliferation and therefore is an important therapeutic target in diseases that involved cellular proliferation such as cancers. Nearly half of present-day antitumor regimens contain at least one prescription that act as a topoisomerase inhibitor. Generally, tumor cells show divergent expression of TOP-IIA compared to normal cells. The remarkable expression of TOP-IIA in various carcinomas provides a significant biomarker toward understanding the nature of malignancy. TOP-IIA expression and amplification studies help in diagnosing cancer and to observe the disease progression, overall survival (OS) of patients, and response to therapy. This review highlights the research output and analysis in exploring the standing of TOP-IIA in various carcinomas. As some reports show contradiction within the same field of interest, the outline of that may help to induce researchers for further investigation and clarification. To the best of our knowledge, this is the first overview briefly summarizing the prognostic feature of TOP-IIA in various types of cancer.
format	Article
author	Ali, Yousaf Abd Hamid, Shafida
author_facet	Ali, Yousaf Abd Hamid, Shafida
author_sort	Ali, Yousaf
title	Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy
title_short	Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy
title_full	Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy
title_fullStr	Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy
title_full_unstemmed	Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy
title_sort	human topoisomerase ii alpha as a prognostic biomarker in cancer chemotherapy
publisher	Springer
publishDate	2016
url	http://irep.iium.edu.my/45324/ http://irep.iium.edu.my/45324/ http://irep.iium.edu.my/45324/ http://irep.iium.edu.my/45324/1/45324.pdf http://irep.iium.edu.my/45324/4/45324_Human%20topoisomerase%20II%20alpha%20as%20a%20prognostic%20biomarker%20in%20cancer%20chemotherapy_SCOPUS.pdf
first_indexed	2023-09-18T21:04:31Z
last_indexed	2023-09-18T21:04:31Z
_version_	1777410843999207424

Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy

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