The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis
Osteoarthritis (OA) is a common degenerative joint disease among elderly population. Previous studies have shown that OA is associated with the subchondral bone remodelling. However, none of these studies focuses on the trabecular bone (Tb) remodelling in the epiphyseal region of tibia. Hence, the...
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| Format: | Conference or Workshop Item |
| Language: | English |
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2018
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| Online Access: | http://irep.iium.edu.my/64805/ http://irep.iium.edu.my/64805/1/MSAB%202018%20abstract.pdf |
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iium-648052018-07-26T09:30:34Z http://irep.iium.edu.my/64805/ The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis Akman, Akma Azmiera Talib, Ain Aisyah Md Yusof, Azirah Khalid, Kamarul Ariffin Yusof, Nurul Asyiqin Abdul Ghani, Radiah Hamdan, Asmah Hanim Zamli, Zaitunnatakhin R Medicine (General) Osteoarthritis (OA) is a common degenerative joint disease among elderly population. Previous studies have shown that OA is associated with the subchondral bone remodelling. However, none of these studies focuses on the trabecular bone (Tb) remodelling in the epiphyseal region of tibia. Hence, the present study aims to determine the mineral apposition rate (MAR), mineralising surface (MS) and bone formation rate (BFR) of Tb Dunkin Hartley (DH) guinea pigs, and its association with microscopic score of OA. The DH was administered with 20 mg/kg of calcein dye at 9 and 2 days prior to euthanasia. The tibia were then collected at 10, 20 and 30 weeks of age. Histomorphometry and histopathology analyses were conducted to quantify the parameters of Tb remodelling and microscopic OA score, respectively. The data showed that the MAR, MS and BFR were higher in the medial side (versus lateral side) of the tibia (p ≤ 0.05), and increased between 10 and 20 weeks of age. However, at the final time point, these parameters were significantly decreased (p ≤ 0.05), and became lower in the medial than the lateral side of Tb. A strong negative correlation was observed between the BFR and microscopic OA scores (r = -1.0, p ≤ 0.01), suggesting that the Tb loss dominates the late stage of OA. 2018-07-01 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/64805/1/MSAB%202018%20abstract.pdf Akman, Akma Azmiera and Talib, Ain Aisyah and Md Yusof, Azirah and Khalid, Kamarul Ariffin and Yusof, Nurul Asyiqin and Abdul Ghani, Radiah and Hamdan, Asmah Hanim and Zamli, Zaitunnatakhin (2018) The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis. In: The 15th Symposium of the Malaysian Society of Applied Biology (MSAB 2018), 29th June - 1st July 2018, Melaka. (Unpublished) |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
R Medicine (General) |
| spellingShingle |
R Medicine (General) Akman, Akma Azmiera Talib, Ain Aisyah Md Yusof, Azirah Khalid, Kamarul Ariffin Yusof, Nurul Asyiqin Abdul Ghani, Radiah Hamdan, Asmah Hanim Zamli, Zaitunnatakhin The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis |
| description |
Osteoarthritis (OA) is a common degenerative joint disease among elderly population. Previous studies have shown that OA is associated with the subchondral bone remodelling. However, none of these studies focuses on the trabecular bone (Tb) remodelling in the epiphyseal region of tibia. Hence, the present study aims to determine the mineral apposition rate (MAR), mineralising surface (MS) and bone formation rate (BFR) of Tb Dunkin Hartley (DH) guinea pigs, and its association with microscopic score of OA. The DH was administered with 20 mg/kg of calcein dye at 9 and 2 days prior to euthanasia. The tibia were then collected at 10, 20 and 30 weeks of age. Histomorphometry and histopathology analyses were conducted to quantify the parameters of Tb remodelling and microscopic OA score, respectively. The data showed that the MAR, MS and BFR were higher in the medial side (versus lateral side) of the tibia (p ≤ 0.05), and increased between 10 and 20 weeks of age. However, at the final time point, these parameters were significantly decreased (p ≤ 0.05), and became lower in the medial than the lateral side of Tb. A strong negative correlation was observed between the BFR and microscopic OA scores (r = -1.0, p ≤ 0.01), suggesting that the Tb loss dominates the late stage of OA. |
| format |
Conference or Workshop Item |
| author |
Akman, Akma Azmiera Talib, Ain Aisyah Md Yusof, Azirah Khalid, Kamarul Ariffin Yusof, Nurul Asyiqin Abdul Ghani, Radiah Hamdan, Asmah Hanim Zamli, Zaitunnatakhin |
| author_facet |
Akman, Akma Azmiera Talib, Ain Aisyah Md Yusof, Azirah Khalid, Kamarul Ariffin Yusof, Nurul Asyiqin Abdul Ghani, Radiah Hamdan, Asmah Hanim Zamli, Zaitunnatakhin |
| author_sort |
Akman, Akma Azmiera |
| title |
The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis |
| title_short |
The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis |
| title_full |
The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis |
| title_fullStr |
The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis |
| title_full_unstemmed |
The remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis |
| title_sort |
remodelling of tibial trabecular bone in spontaneous animal model of osteoarthritis |
| publishDate |
2018 |
| url |
http://irep.iium.edu.my/64805/ http://irep.iium.edu.my/64805/1/MSAB%202018%20abstract.pdf |
| first_indexed |
2023-09-18T21:31:59Z |
| last_indexed |
2023-09-18T21:31:59Z |
| _version_ |
1777412571643510784 |