Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives
A series of twenty-four 2-benzoyl-6-benzylidenecyclohexanone analogs were synthesized and evaluated for their nitric oxide inhibition and antioxidant activity. Six compounds (3, 8, 10, 17, 18 and 19) were found to exhibit significant NO inhibitory activity in LPS/IFN-induced RAW 264.7 macrophages,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/73756/ http://irep.iium.edu.my/73756/ http://irep.iium.edu.my/73756/ http://irep.iium.edu.my/73756/1/Kamal%20Rullah%209.pdf |
| Summary: | A series of twenty-four 2-benzoyl-6-benzylidenecyclohexanone analogs were synthesized and evaluated
for their nitric oxide inhibition and antioxidant activity. Six compounds (3, 8, 10, 17, 18 and 19) were
found to exhibit significant NO inhibitory activity in LPS/IFN-induced RAW 264.7 macrophages, of which
compound 10 demonstrated the highest activity with the IC50 value of 4.2 ± 0.2 lM. Furthermore, two
compounds (10 and 17) displayed antioxidant activity upon both the DPPH scavenging and FRAP
analyses. However, none of the 2-benzoyl-6-benzylidenecyclohexanone analogs significantly scavenged
NO radical. Structure-activity comparison suggested that 3,4-dihydroxylphenyl ring is crucial for
bioactivities of the 2-benzoyl-6-benzylidenecyclohexanone analogs. The results from this study and
the reports from previous studies indicated that compound 10 could be a candidate for further
investigation on its potential as a new anti-inflammatory agent |
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